OPTIMIZERx (OPRX) had the highest return between 2007 and 2008 by a small-cap US stock, returning 2,384%.

ASSET	YEARS	% RETURN
OPTIMIZERx (OPRX)	2007-2008	2,384%
MiMedx (MDXG)	2007-2008	1,323.03%
Lineage Cell Therapeutics (LCTX)	2007-2008	567.94%
Axogen (AXGN)	2007-2008	276.72%
Metalla Royalty & Streaming (MTA)	2007-2008	216.67%
Emergent Biosolutions (EBS)	2007-2008	129.04%
Myriad Genetics (MYGN)	2007-2008	111.15%
Strategic Education (STRA)	2007-2008	106.92%
Graham (GHM)	2007-2008	106.42%
Crawford (CRD.B)	2007-2008	97.29%
Sohu (SOHU)	2007-2008	97.25%
Compass Minerals International (CMP)	2007-2008	96.72%
Opko Health (OPK)	2007-2008	86.21%
Shenandoah Telecommunications (SHEN)	2007-2008	83.79%
Allegiant Travel (ALGT)	2007-2008	71.26%
ICF International (ICFI)	2007-2008	66.58%
Neogen (NEOG)	2007-2008	65.43%
Stepan (SCL)	2007-2008	59.13%
Cryoport (CYRX)	2007-2008	56.67%
Fresh Del Monte Produce (FDP)	2007-2008	48.97%
Village Super Market (VLGEA)	2007-2008	48.93%
National Presto Industries (NPK)	2007-2008	48.65%
O-I Glass (OI)	2007-2008	47.89%
Titan Machinery (TITN)	2007-2008	46.15%
Transcat (TRNS)	2007-2008	44.44%

Small-cap stocks are treated as having a market cap between $300M and $2B.