Advanced Micro Devices (AMD) had the highest return between 2016 and 2019 by a US stock with a market cap of $50B+, returning 1,555.6%.

ASSET	YEARS	% RETURN
Advanced Micro Devices (AMD)	2016-2019	1,555.6%
NVIDIA (NVDA)	2016-2019	643.57%
MercadoLibre (MELI)	2016-2019	412.37%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2016-2019	372.34%
Axon Enterprise (AXON)	2016-2019	331.06%
Apollo Global Management LLC Class A (APO)	2016-2019	315.01%
Lam Research (LRCX)	2016-2019	303.34%
Micron Technology (MU)	2016-2019	288.86%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2016-2019	278.68%
Ferrari (RACE)	2016-2019	263.53%
IDEXX Laboratories (IDXX)	2016-2019	260.93%
Adobe Systems (ADBE)	2016-2019	259.39%
ASML Holding NV ADR (ASML)	2016-2019	255.16%
Danaher (DHR)	2016-2019	255.14%
Applied Materials (AMAT)	2016-2019	253.86%
Ares Management (ARES)	2016-2019	249.97%
Fortinet (FTNT)	2016-2019	249.57%
Cadence Design Systems (CDNS)	2016-2019	246.8%
ServiceNow (NOW)	2016-2019	232.22%
Transdigm (TDG)	2016-2019	226.36%
Marvell Technology (MRVL)	2016-2019	224.34%
Intuitive Surgical (ISRG)	2016-2019	224.12%
Mastercard (MA)	2016-2019	221.47%
Microsoft (MSFT)	2016-2019	215.17%
Cintas (CTAS)	2016-2019	213.29%