InterContinental Hotels Group PLC ADR (IHG) had the highest return between 2001 and 2010 by a US stock, returning 14,004,900%.

ASSET	YEARS	% RETURN
InterContinental Hotels Group PLC ADR (IHG)	2001-2010	14,004,900%
Northern Oil & Gas (NOG)	2001-2010	8,922,465.38%
QVC (QVCGA)	2001-2010	8,177,603.7%
Know Labs (KNW)	2001-2010	4,885,152.16%
Houston American Energy (HUSA)	2001-2010	4,701,043.45%
Hirequest (HQI)	2001-2010	2,146,250%
India Globalization Capital (IGC)	2001-2010	966,566.67%
National Grid PLC ADR (NGG)	2001-2010	913,423.81%
Natwest (NWG)	2001-2010	774,270%
Perspective Therapeutics (CATX)	2001-2010	376,566.67%
Aris Mining (ARMN)	2001-2010	326,680.13%
Gladstone Capital (GLAD)	2001-2010	292,020%
Ferguson (FERG)	2001-2010	212,023.96%
Ring Energy (REI)	2001-2010	133,233.33%
First Majestic Silver (AG)	2001-2010	63,584%
Ocean Power Technologies (OPTT)	2001-2010	63,455.56%
Gyre Therapeutics (GYRE)	2001-2010	56,089.27%
Gulf Resources (GURE)	2001-2010	53,350%
Pioneer Power Solutions (PPSI)	2001-2010	29,429.23%
OPTIMIZERx (OPRX)	2001-2010	24,500%
Future Fintech (FTFT)	2001-2010	23,150%
NanoViricides (NNVC)	2001-2010	20,480%
MEDIFAST (MED)	2001-2010	20,446.9%
Companhia Siderurgica Nacional ADR (SID)	2001-2010	16,200.97%
ImmunoPrecise Antibodies (HYFT)	2001-2010	11,900%