Helport AI Limited Ordinary Shares (HPAI) had the highest return between 2015 and 2023 by a US stock, returning 10,784,900%.

ASSET	YEARS	% RETURN
Helport AI Limited Ordinary Shares (HPAI)	2015-2023	10,784,900%
Azitra (AZTR)	2015-2023	3,285,614.29%
MDxHealth SA ADR (MDXH)	2015-2023	656,566.67%
Moolec Science SA Ordinary Shares (MLEC)	2015-2023	564,120.18%
KULR Technology (KULR)	2015-2023	379,900%
LMF Acquisition Opportunities (ICU)	2015-2023	282,234.18%
Integra Resources (ITRG)	2015-2023	211,900%
Immatics (IMTX)	2015-2023	210,500%
Blackboxstocks (BLBX)	2015-2023	165,782.35%
BioNexus Gene Lab Corp Common stock (BGLC)	2015-2023	129,168.29%
Iqstel (IQST)	2015-2023	119,085.86%
Next Technology (NXTT)	2015-2023	71,051.36%
Applied Digital (APLD)	2015-2023	69,384.54%
SurgePays (SURG)	2015-2023	64,400%
Lottery (SEGG)	2015-2023	55,432.79%
GeoVax Labs (GOVX)	2015-2023	50,507.48%
Heart Test Laboratories Inc Common Stock (HSCS)	2015-2023	50,194.12%
AquaBounty Technologies (AQB)	2015-2023	39,483.33%
Celsius (CELH)	2015-2023	32,605.46%
FingerMotion (FNGR)	2015-2023	32,060%
Alarum Technologies (ALAR)	2015-2023	22,790.86%
GT Biopharma (GTBP)	2015-2023	21,757.14%
Eastside Distilling (BLNE)	2015-2023	19,240.33%
Guardforce AI (GFAI)	2015-2023	15,861.54%
Aura Minerals Inc Common Shares (AUGO)	2015-2023	12,413.65%