Expedia (EXPE) had the highest return between 2004 and 2005 by a large-cap US stock, returning 5,826.9%.

ASSET	YEARS	% RETURN
Expedia (EXPE)	2004-2005	5,826.94%
Monster Beverage (MNST)	2004-2005	1,772.18%
Paramount Skydance Corporation Class B Common Stock (PSKY)	2004-2005	818.45%
Intuitive Surgical (ISRG)	2004-2005	585.79%
Apple (AAPL)	2004-2005	567.29%
Cheniere Energy (LNG)	2004-2005	536.79%
Banco Bradesco SA ADR (BBD)	2004-2005	513.71%
Grupo Cibest (CIB)	2004-2005	501.39%
CME (CME)	2004-2005	414.47%
WESCO International (WCC)	2004-2005	381.74%
Valero Energy (VLO)	2004-2005	345.45%
HF Sinclair (DINO)	2004-2005	336.16%
Hologic (HOLX)	2004-2005	333.62%
Alphabet Inc Class A (GOOGL)	2004-2005	314.86%
Canadian Natural Resources (CNQ)	2004-2005	297.81%
Nasdaq (NDAQ)	2004-2005	290.89%
Sterling Construction (STRL)	2004-2005	276.51%
Tenaris SA ADR (TS)	2004-2005	269.82%
Autodesk (ADSK)	2004-2005	253.38%
QXO (QXO)	2004-2005	250%
Woori Financial (WF)	2004-2005	239.85%
America Movil SAB de CV ADR (AMX)	2004-2005	230.47%
Cameco (CCJ)	2004-2005	229.31%
Clean Harbors (CLH)	2004-2005	224.07%
Teck Resources Ltd Class B (TECK)	2004-2005	224.07%

Large-cap stocks are treated as having a market cap of $10B+.