Natwest (NWG) had the highest return between 2002 and 2007 by a US stock with a market cap of $50B+, returning 9,034,940%.

ASSET	YEARS	% RETURN
Natwest (NWG)	2002-2007	9,034,940%
National Grid PLC ADR (NGG)	2002-2007	1,948,407.14%
NetEase (NTES)	2002-2007	10,018.31%
Monster Beverage (MNST)	2002-2007	8,250.23%
Southern Copper (SCCO)	2002-2007	2,557.26%
CME (CME)	2002-2007	1,724.84%
Apple (AAPL)	2002-2007	1,695.95%
Intuitive Surgical (ISRG)	2002-2007	1,547.87%
Petroleo Brasileiro Petrobras SA ADR (PBR)	2002-2007	1,392.5%
ICICI Bank (IBN)	2002-2007	1,376.52%
Petróleo Brasileiro SA - Petrobras (PBR.A)	2002-2007	1,265.05%
Canadian Natural Resources (CNQ)	2002-2007	1,188.61%
Axon Enterprise (AXON)	2002-2007	1,163.28%
America Movil SAB de CV ADR (AMX)	2002-2007	931.3%
HDFC Bank Limited ADR (HDB)	2002-2007	850.89%
BHP (BHP)	2002-2007	835.23%
Freeport-McMoran Copper & Gold (FCX)	2002-2007	833.28%
Amazon (AMZN)	2002-2007	747.11%
Brookfield (BN)	2002-2007	687.66%
Altria (MO)	2002-2007	677.2%
Cummins (CMI)	2002-2007	648.05%
Valero Energy (VLO)	2002-2007	628.36%
Alphabet Inc Class A (GOOGL)	2002-2007	591.42%
Rio Tinto ADR (RIO)	2002-2007	557.64%
Williams Companies (WMB)	2002-2007	529.69%