Natwest (NWG) had the best month between 2007 and 2010 by a US stock in October 2007, returning 11,043,860%.

ASSET	MONTH	% RETURN
VirnetX Holding Corp Common Stock (VHC)	January 2007	348.28%
Cryoport (CYRX)	January 2007	410%
Champions Oncology (CSBR)	January 2007	1,350%
Oxley Bridge Acquisition Limited Class A Ordinary Shares (OBA)	January 2007	1,852.94%
Ageagle Aerial Systems (UAVS)	January 2007	299,899.86%
Galectin Therapeutics (GALT)	February 2007	328.57%
Oxley Bridge Acquisition Limited Class A Ordinary Shares (OBA)	February 2007	778.79%
Travere Therapeutics (TVTX)	February 2007	300%
Sanara Medtech (SMTI)	February 2007	350%
Kandi Technologies (KNDI)	February 2007	240%
Intelligent Protection Management (IPM)	March 2007	150%
Opko Health (OPK)	March 2007	80.98%
Fennec Pharmaceuticals (FENC)	March 2007	86.21%
ACADIA Pharmaceuticals (ACAD)	March 2007	123.18%
Travere Therapeutics (TVTX)	March 2007	150%
Northern Oil & Gas (NOG)	April 2007	7,246,825%
Xos (XOS)	April 2007	100.96%
Cryoport (CYRX)	April 2007	189.47%
Oxley Bridge Acquisition Limited Class A Ordinary Shares (OBA)	April 2007	26,423.81%
Ring Energy (REI)	April 2007	184,237.35%
Champions Oncology (CSBR)	May 2007	157.69%
Axogen (AXGN)	May 2007	225%
Sanara Medtech (SMTI)	May 2007	150%
Dolphin Entertainment (DLPN)	May 2007	129.17%
Ageagle Aerial Systems (UAVS)	May 2007	3,076,821.81%