McKesson (MCK) had the lowest return between 1993 and 1995 by a large-cap US stock, returning -100%.

ASSET	YEARS	% RETURN
McKesson (MCK)	1993-1995	-100%
Arrowhead Pharmaceuticals (ARWR)	1993-1995	-94.44%
Monster Beverage (MNST)	1993-1995	-84.65%
Clean Harbors (CLH)	1993-1995	-80%
Insmed (INSM)	1993-1995	-74.37%
Deckers Outdoor (DECK)	1993-1995	-70.52%
Old Dominion Freight Line (ODFL)	1993-1995	-63.22%
Laboratory Corporation of America (LH)	1993-1995	-47.27%
Apple (AAPL)	1993-1995	-44.39%
Leonardo DRS, Inc Common Stock (DRS)	1993-1995	-44%
POSCO (PKX)	1993-1995	-41.82%
Tyler Technologies (TYL)	1993-1995	-38.89%
Cheniere Energy (LNG)	1993-1995	-37.5%
Church & Dwight (CHD)	1993-1995	-37.38%
NVR (NVR)	1993-1995	-33.33%
Walmart (WMT)	1993-1995	-29.26%
Westinghouse Air Brake Technologies (WAB)	1993-1995	-29.09%
CVS Health (CVS)	1993-1995	-25.9%
JB Hunt Transport Services (JBHT)	1993-1995	-25.52%
Sterling Construction (STRL)	1993-1995	-23.08%
HF Sinclair (DINO)	1993-1995	-21.65%
PACCAR (PCAR)	1993-1995	-19.19%
Costco Wholesale (COST)	1993-1995	-18.12%
Advanced Energy Industries (AEIS)	1993-1995	-16.28%
Contura Energy (CTRA)	1993-1995	-15.39%

Large-cap stocks are treated as having a market cap of $10B+.