Donovan Mitchell has the most points for the Cavaliers in a game, with 71 points against the Bulls on January 2, 2023.

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Regular season

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Donovan Mitchell D. Mitchell	71	1/2/2023	CLE	vs	CHI	50	8	11	0	1	22	34	64.7	7	15	46.7	20	25	80.0	78.9	3	5	4	3	+19
2	LeBron James L. James	57	11/3/2017	CLE	@	WAS	43	11	7	3	2	23	34	67.6	2	4	50.0	9	9	100.0	75.1	5	6	3	2	+6
3	Kyrie Irving K. Irving	57	3/12/2015	CLE	@	SAS	47	3	5	4	0	20	32	62.5	7	7	100.0	10	10	100.0	78.3	1	2	2	3	+6
4	LeBron James L. James	56	3/20/2005	CLE	@	TOR	48	10	5	2	0	18	36	50.0	6	12	50.0	14	15	93.3	65.7	2	8	4	0	-7
5	Kyrie Irving K. Irving	55	1/28/2015	CLE	vs	POR	39	4	5	2	0	17	36	47.2	11	19	57.9	10	10	100.0	68.1	2	2	3	0	+12
6	LeBron James L. James	55	2/20/2009	CLE	@	MIL	40	5	9	0	0	16	29	55.2	8	11	72.7	15	22	68.2	71.1	1	4	6	3	+13
7	LeBron James L. James	52	2/4/2009	CLE	@	NYK	44	9	11	0	2	17	33	51.5	2	7	28.6	16	19	84.2	62.9	0	9	3	1	+7
8	LeBron James L. James	52	12/10/2005	CLE	@	MIL	43	7	7	2	0	19	29	65.5	5	9	55.6	9	10	90.0	77.8	0	7	3	5	-3
9	Darius Garland D. Garland	51	11/13/2022	CLE	vs	MIN	40	2	6	2	0	16	31	51.6	10	15	66.7	9	13	69.2	69.4	1	1	2	3	+6
10	LeBron James L. James	51	3/13/2009	CLE	@	SAC	47	4	9	2	3	16	30	53.3	4	11	36.4	15	17	88.2	68.0	0	4	3	2	+6
11	LeBron James L. James	51	1/15/2008	CLE	@	MEM	47	8	9	3	1	18	28	64.3	6	12	50.0	9	16	56.3	72.8	3	5	4	1	+10
12	LeBron James L. James	51	1/21/2006	CLE	@	UTA	43	5	8	2	0	19	35	54.3	4	8	50.0	9	11	81.8	64.0	0	5	3	4	+19
13	LeBron James L. James	50	3/5/2008	CLE	@	NYK	44	8	10	4	0	16	30	53.3	7	13	53.8	11	16	68.8	67.5	1	7	2	3	+11
14	Walt Wesley W. Wesley	50	2/19/1971	CLE	vs	CIN	44	12	1			20	34	58.8				10	14	71.4	62.3				3
15	Kyrie Irving K. Irving	49	1/23/2017	CLE	@	NOP	42	2	4	2	1	15	28	53.6	8	14	57.1	11	11	100.0	74.6	0	2	0	4	+12
16	Donovan Mitchell D. Mitchell	48	12/12/2025	CLE	@	WAS	35	4	4	2	0	17	31	54.8	8	15	53.3	6	6	100.0	71.3	0	4	3	1	+9
17	LeBron James L. James	48	12/30/2009	CLE	vs	ATL	43	10	6	2	2	15	23	65.2	4	6	66.7	14	16	87.5	79.9	3	7	3	3	+7
18	LeBron James L. James	47	2/6/2010	CLE	vs	NYK	44	8	8	5	0	17	31	54.8	6	12	50.0	7	7	100.0	69.0	1	7	5	2	+4
19	LeBron James L. James	47	2/10/2009	CLE	@	IND	41	7	4	1	1	15	21	71.4	4	7	57.1	13	14	92.9	86.5	0	7	7	1	+7
20	LeBron James L. James	47	4/1/2006	CLE	vs	MIA	45	12	9	2	0	16	25	64.0	2	6	33.3	13	14	92.9	75.4	4	8	4	3	+13
21	LeBron James L. James	47	3/12/2006	CLE	@	MIA	45	7	4	0	1	11	27	40.7	1	6	16.7	24	28	85.7	59.8	2	5	5	2	-7
22	Donovan Mitchell D. Mitchell	46	11/5/2025	CLE	vs	PHI	35	4	8	1	0	15	21	71.4	6	11	54.5	10	10	100.0	90.6	0	4	2	0	+17
23	Donovan Mitchell D. Mitchell	46	1/10/2023	CLE	@	UTA	36	5	6	3	0	14	27	51.9	7	18	38.9	11	11	100.0	72.2	1	4	0	0	-4
24	Darius Garland D. Garland	46	12/26/2022	CLE	vs	BKN	40	3	8	1	0	14	20	70.0	5	7	71.4	13	15	86.7	86.5	1	2	1	1	+6
25	Kyrie Irving K. Irving	46	3/19/2017	CLE	@	LAL	38	2	3	0	0	15	21	71.4	6	10	60.0	10	10	100.0	90.6	0	2	3	2	+9