Keegan Murray has his most career points per game against the Heat, with 22.5 per game.

keegan murray highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Heat	22.5	4	34.4	3.8	2.3	1.3	1.8	2.0	8.3	13.0	63.5	4.3	7.5	56.7	1.8	2.0	87.5	137	90	15	9	5	7	8	15	+7
Jazz	22.0	7	33.5	5.4	1.7	1.0	0.7	0.1	8.0	14.6	54.9	5.3	10.0	52.9	0.7	1.3	55.6	234	154	38	12	7	5	1	13	+105
Thunder	18.4	7	35.6	9.1	2.0	1.3	0.4	1.0	6.4	12.9	50.0	2.7	7.3	37.3	2.9	3.0	95.2	249	129	64	14	9	3	7	9	-7
Magic	17.0	4	33.5	6.0	1.5	0.8	0.5	0.3	6.8	11.5	58.7	3.5	5.8	60.9	0.0	0.0		134	68	24	6	3	2	1	8	+14
Clippers	16.9	7	34.7	5.7	1.3	1.4	0.7	0.9	6.4	12.9	50.0	2.3	6.6	34.8	1.7	2.0	85.7	243	118	40	9	10	5	6	14	+35
Cavaliers	16.8	4	32.7	3.5	1.0	1.0	0.5	0.3	6.0	10.0	60.0	4.3	6.8	63.0	0.5	0.5	100.0	131	67	14	4	4	2	1	11	+22
Pistons	16.3	4	31.2	3.3	1.8	0.5	0.8	1.3	6.0	11.0	54.5	2.5	6.0	41.7	1.8	2.0	87.5	125	65	13	7	2	3	5	8	+52
Wizards	15.8	4	29.8	4.0	2.0	1.0	0.8	0.3	6.0	12.8	47.1	3.0	6.3	48.0	0.8	1.3	60.0	119	63	16	8	4	3	1	9	+10
Knicks	14.5	4	31.5	5.3	0.8	0.5	0.8	0.5	5.0	12.3	40.8	2.5	7.5	33.3	2.0	2.5	80.0	126	58	21	3	2	3	2	14	-20
Nets	14.5	4	28.9	4.0	1.8	0.3	1.0	0.3	5.5	11.3	48.9	2.5	5.5	45.5	1.0	1.0	100.0	116	58	16	7	1	4	1	9	+37
Hornets	14.5	4	33.0	3.5	1.8	1.3	0.8	0.5	6.0	13.5	44.4	2.3	6.3	36.0	0.3	1.0	25.0	132	58	14	7	5	3	2	12	+20
Rockets	13.7	7	30.3	4.9	0.9	1.1	0.3	0.9	4.9	11.7	41.5	2.6	7.3	35.3	1.4	1.4	100.0	212	96	34	6	8	2	6	16	-22
Raptors	13.5	4	32.7	6.8	1.5	0.8	0.8	1.3	5.3	11.3	46.7	2.5	6.0	41.7	0.5	1.0	50.0	131	54	27	6	3	3	5	7	+20
76ers	13.5	4	33.7	4.3	2.3	0.8	1.3	0.8	5.0	12.0	41.7	2.5	7.5	33.3	1.0	1.5	66.7	135	54	17	9	3	5	3	9	-3
Mavericks	13.3	7	33.5	5.0	1.9	0.4	0.9	0.4	4.7	10.1	46.5	2.3	5.9	39.0	1.6	2.0	78.6	235	93	35	13	3	6	3	18	-8
Warriors	13.1	7	36.1	5.4	1.4	1.6	0.6	1.1	5.0	13.1	38.0	2.3	7.6	30.2	0.9	1.1	75.0	253	92	38	10	11	4	8	16	-14
Lakers	12.9	8	32.6	5.3	1.9	1.3	0.4	1.0	4.5	9.9	45.6	2.9	7.0	41.1	1.0	1.4	72.7	261	103	42	15	10	3	8	22	+65
Suns	12.3	9	28.9	4.0	1.8	0.7	0.6	0.7	5.0	10.4	47.9	2.0	5.2	38.3	0.3	0.4	75.0	260	111	36	16	6	5	6	29	-16
Pacers	12.3	4	29.3	5.8	0.5	0.5	0.5	1.5	4.5	10.8	41.9	1.3	6.0	20.8	2.0	2.3	88.9	117	49	23	2	2	2	6	6	+21
Pelicans	11.7	7	29.5	3.7	0.9	0.9	0.3	0.6	3.9	9.9	39.1	2.9	7.1	40.0	1.1	1.1	100.0	206	82	26	6	6	2	4	14	-79
Nuggets	11.7	7	28.0	3.4	1.1	0.6	0.4	1.1	4.6	10.1	45.1	1.6	5.3	29.7	1.0	1.1	87.5	196	82	24	8	4	3	8	12	-39
Trail Blazers	11.5	6	28.1	4.3	1.8	0.7	1.5	0.5	4.5	11.8	38.0	2.2	6.5	33.3	0.3	0.3	100.0	169	69	26	11	4	9	3	14	+41
Grizzlies	11.4	7	31.0	5.6	1.3	0.9	0.1	1.3	4.4	11.3	39.2	2.1	5.9	36.6	0.4	0.9	50.0	217	80	39	9	6	1	9	10	+29
Celtics	10.3	4	32.4	6.8	1.5	0.8	0.5	1.5	4.0	12.0	33.3	2.3	8.3	27.3	0.0	0.0		130	41	27	6	3	2	6	13	-42
Timberwolves	10.2	6	33.5	6.3	0.7	1.2	0.3	0.5	4.0	10.2	39.3	1.7	5.3	31.3	0.5	0.7	75.0	201	61	38	4	7	2	3	15	-5