Kobe Bryant averaged 24.6 points, 5.2 assists and 5.0 rebounds in 22 games versus LeBron James in his career.

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Regular season

	NAME	DATE	TM		OPP	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Kobe Bryant K. Bryant	1/12/2004	LAL	vs	CLE	17	10	5	2	1	0	3	8	37.5	0	0		4	5	80.0	49.0	1	4	0	1	+2
2	Kobe Bryant K. Bryant	1/13/2005	LAL	vs	CLE	6	2	0	3	0	0	1	2	50.0	0	1	0.0	0	0		50.0	0	0	1	0	0
3	Kobe Bryant K. Bryant	2/13/2005	LAL	@	CLE	41	26	4	6	2	0	7	22	31.8	1	4	25.0	11	11	100.0	48.4	1	3	4	3	-15
4	Kobe Bryant K. Bryant	1/12/2006	LAL	vs	CLE	37	27	2	2	2	0	9	21	42.9	1	5	20.0	8	8	100.0	55.1	0	2	5	4	-2
5	Kobe Bryant K. Bryant	3/19/2006	LAL	@	CLE	45	38	6	5	3	1	15	33	45.5	1	4	25.0	7	7	100.0	52.7	0	6	3	4	+2
6	Kobe Bryant K. Bryant	2/11/2007	LAL	@	CLE	44	36	7	6	1	0	12	24	50.0	1	5	20.0	11	11	100.0	62.4	0	7	4	5	-4
7	Kobe Bryant K. Bryant	2/15/2007	LAL	vs	CLE	41	34	6	5	2	0	9	22	40.9	2	7	28.6	14	15	93.3	59.4	1	5	6	3	-3
8	Kobe Bryant K. Bryant	12/20/2007	LAL	@	CLE	40	21	5	5	1	0	8	22	36.4	0	3	0.0	5	8	62.5	41.1	1	4	2	2	+8
9	Kobe Bryant K. Bryant	1/27/2008	LAL	vs	CLE	43	33	12	6	0	1	10	21	47.6	0	1	0.0	13	18	72.2	57.1	2	10	3	3	+8
10	Kobe Bryant K. Bryant	1/19/2009	LAL	vs	CLE	41	20	6	12	1	1	9	22	40.9	1	5	20.0	1	3	33.3	42.9	1	5	5	1	+16
11	Kobe Bryant K. Bryant	2/8/2009	LAL	@	CLE	35	19	3	2	1	0	8	17	47.1	0	2	0.0	3	3	100.0	51.9	0	3	2	2	+4
12	Kobe Bryant K. Bryant	12/25/2009	LAL	vs	CLE	45	35	10	8	1	1	11	33	33.3	1	3	33.3	12	12	100.0	45.7	3	7	4	3	-18
13	Kobe Bryant K. Bryant	1/21/2010	LAL	@	CLE	40	31	2	4	0	0	12	31	38.7	2	6	33.3	5	8	62.5	44.9	1	1	3	2	-8
14	Kobe Bryant K. Bryant	12/25/2010	LAL	vs	MIA	40	17	6	7	1	0	6	16	37.5	1	3	33.3	4	5	80.0	46.7	1	5	4	5	-21
15	Kobe Bryant K. Bryant	3/10/2011	LAL	@	MIA	40	24	2	2	1	0	8	21	38.1	4	8	50.0	4	5	80.0	51.7	0	2	3	3	+3
16	Kobe Bryant K. Bryant	1/19/2012	LAL	@	MIA	41	24	5	7	3	0	8	21	38.1	3	6	50.0	5	5	100.0	51.7	1	4	2	1	-2
17	Kobe Bryant K. Bryant	3/4/2012	LAL	vs	MIA	39	33	3	1	0	0	14	23	60.9	0	2	0.0	5	7	71.4	63.3	1	2	3	0	+8
18	Kobe Bryant K. Bryant	1/17/2013	LAL	vs	MIA	43	22	4	1	1	0	8	25	32.0	4	9	44.4	2	2	100.0	42.5	1	3	6	4	-9
19	Kobe Bryant K. Bryant	2/10/2013	LAL	@	MIA	37	28	6	9	1	0	11	19	57.9	0	0		6	8	75.0	62.2	1	5	4	2	-14
20	Kobe Bryant K. Bryant	1/15/2015	LAL	vs	CLE	32	19	6	17	0	0	7	14	50.0	3	6	50.0	2	3	66.7	62.0	1	5	3	0	+3
21	Kobe Bryant K. Bryant	2/10/2016	LAL	@	CLE	33	17	6	3	1	0	5	16	31.3	3	7	42.9	4	4	100.0	47.9	0	6	3	2	-19
22	Kobe Bryant K. Bryant	3/10/2016	LAL	vs	CLE	32	26	5	2	1	1	11	16	68.8	3	4	75.0	1	2	50.0	77.0	1	4	0	1	-8
	Average					36.9	24.6	5.0	5.2	1.1	0.2	8.7	20.4	42.8	1.4	4.1	34.1	5.8	6.8	84.7	52.6	0.8	4.2	3.2	2.3	-3.1
	Total					811	542	111	115	24	5	192	449	42.8	31	91	34.1	127	150	84.7	52.6	18	93	70	51	-69