The Los Angeles Lakers had their highest point differential in a game against the Warriors on March 19, 1972, with a 63 point differential.

Interpreted as:

lakers highest point differential regular-season games

	TEAM	DIFF	DATE	TM		OPP	RESULT	MIN	PTS	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF
1	Lakers	63	3/19/1972	LAL	vs	GSW	W 162-99	240	162	73	43			69	113	61.1				24	32	75.0	63.7				21
2	Lakers	56	11/12/1966	LAL	vs	DET	W 144-88	240	144	75	32			53	97	54.6				38	44	86.4	61.9				19
3	Lakers	55	1/11/2011	LAL	vs	CLE	W 112-57	240	112	53	25	11	7	46	86	53.5	10	20	50.0	10	15	66.7	60.5	13	40	12	14
4	Lakers	49	2/3/1967	LAL	vs	SFW	W 129-80	240	129	81	36			53	118	44.9				23	30	76.7	49.2				25
5	Lakers	47	11/23/1988	LAL	@	MIA	W 138-91	240	138	46	35	11	8	56	87	64.4	0	6	0.0	26	34	76.5	67.7	8	38	10	13
6	Lakers	47	12/16/1951	MIN	vs	MIL	W 99-52	240	99					41	102	40.2				17	29	58.6	43.1				22
7	Lakers	46	1/9/2004	LAL	vs	ATL	W 113-67	240	113	45	33	12	6	47	92	51.1	6	14	42.9	13	15	86.7	57.3	19	26	8	20
8	Lakers	46	2/4/2000	LAL	vs	UTA	W 113-67	240	113	53	27	12	10	34	69	49.3	5	12	41.7	40	55	72.7	60.6	14	39	16	26
9	Lakers	46	3/5/1986	LAL	vs	UTA	W 130-84	240	130	42	35	19	8	52	83	62.7	5	7	71.4	21	30	70.0	67.6	7	35	17	22
10	Lakers	46	11/13/1979	LAL	@	SDC	W 137-91	240	137	47	34	12	3	60	89	67.4	0	1	0.0	17	23	73.9	69.1	9	38	15	11
11	Lakers	44	12/7/2023	LAL	vs	NOP	W 133-89	240	133	59	31	6	4	47	86	54.7	17	35	48.6	22	29	75.9	67.3	11	48	15	16
12	Lakers	44	1/7/1972	LAL	@	ATL	W 134-90	240	134	54	41			58	100	58.0				18	21	85.7	61.3				17
13	Lakers	44	2/6/1968	LAL	vs	CIN	W 146-102	240	146	63	41			57	97	58.8				32	41	78.0	63.5				27
14	Lakers	44	3/16/1952	MIN	vs	BAL	W 126-82	240	126					54	121	44.6				18	23	78.3	48.0				22
15	Lakers	43	3/4/1973	LAL	vs	CLE	W 127-84	240	127	61	36			53	99	53.5				21	26	80.8	57.5				20
16	Lakers	43	2/22/1950	MIN	vs	STL	W 100-57	240	100		20			43	116	37.1				14	23	60.9	39.6				18
17	Lakers	41	3/12/2002	LAL	vs	CHA	W 107-66	240	107	52	24	13	8	42	92	45.7	4	11	36.4	19	25	76.0	51.9	16	36	9	19
18	Lakers	41	12/27/1977	LAL	@	GSW	W 123-82	240	123	60	39	16	5	57	106	53.8				9	10	90.0	55.7	16	44	16	19
19	Lakers	40	1/15/2010	LAL	vs	LAC	W 126-86	240	126	40	28	7	7	41	82	50.0	10	22	45.5	34	41	82.9	63.0	7	33	7	18
20	Lakers	40	3/30/1989	LAL	vs	SAS	W 138-98	240	138	47	36	16	10	47	87	54.0	4	7	57.1	40	46	87.0	64.3	13	34	20	28
21	Lakers	40	3/8/1989	LAL	@	MIA	W 127-87	240	127	57	32	7	12	52	92	56.5	3	6	50.0	20	22	90.9	62.5	19	38	20	14
22	Lakers	40	11/19/1972	LAL	vs	PHI	W 135-95	240	135	68	36			58	114	50.9				19	23	82.6	54.4				21
23	Lakers	40	11/10/1971	LAL	@	PHI	W 143-103	240	143	69	33			60	113	53.1				23	27	85.2	57.3				21
24	Lakers	39	1/14/2002	LAL	vs	MEM	W 120-81	240	120	45	32	14	8	48	97	49.5	10	22	45.5	14	17	82.4	57.4	15	30	8	17
25	Lakers	39	2/19/1998	LAL	vs	DEN	W 131-92	240	131	52	31	10	8	46	85	54.1	9	23	39.1	30	44	68.2	62.8	15	37	14	20