Between the 1999-00 and 2008-09 seasons, Kobe Bryant had the most games with 20+ points, with 605 games.

Interpreted as:

most 20 or more points regular-season game by a player in the 2000s

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Kobe Bryant K. Bryant	605	18,881	40.3	31.2	6.0	5.2	1.7	0.6	10.8	23.0	47.0	1.6	4.4	35.9	8.0	9.4	84.5	57.4	1.4	4.6	3.2	24,373	3,627	3,134	1,046	357	1,907	1,712	+3163
2	Dirk Nowitzki D. Nowitzki	563	15,373	39.1	27.3	9.4	2.9	1.0	1.1	9.5	19.0	50.1	1.6	3.8	41.9	6.7	7.6	88.1	61.1	1.4	8.0	2.0	22,018	5,282	1,632	550	606	1,137	1,474	+3967
3	Allen Iverson A. Iverson	556	17,294	43.0	31.1	3.8	6.3	2.4	0.2	10.7	24.3	44.1	1.3	3.9	33.0	8.4	10.4	80.1	53.8	0.7	3.1	3.7	23,892	2,098	3,529	1,310	87	2,052	1,004	+1851
4	Paul Pierce P. Pierce	505	13,960	39.3	27.6	6.7	4.1	1.6	0.6	9.0	19.0	47.2	2.1	5.1	40.3	7.7	9.5	81.0	59.7	1.0	5.7	3.2	19,858	3,399	2,060	831	325	1,608	1,482	+1572
5	Vince Carter V. Carter	503	14,106	39.6	28.0	5.8	4.5	1.4	0.8	10.2	21.5	47.4	2.0	4.8	41.2	5.7	7.1	81.0	57.0	1.8	4.1	2.5	19,921	2,942	2,244	686	418	1,235	1,562	+1520
6	Kevin Garnett K. Garnett	490	12,347	39.5	25.2	12.6	4.9	1.4	1.6	9.8	18.4	53.0	0.2	0.7	33.9	5.4	6.7	81.0	58.9	2.8	9.8	2.6	19,373	6,190	2,402	667	791	1,292	1,256	+2542
7	Tracy McGrady T. McGrady	456	13,482	39.9	29.6	6.8	5.5	1.5	0.9	10.7	23.3	46.0	1.9	5.2	36.8	6.3	8.1	76.8	55.0	1.5	5.2	2.6	18,183	3,081	2,494	693	408	1,197	895	+1843
8	Tim Duncan T. Duncan	454	11,784	39.0	26.0	12.6	3.3	0.8	2.5	9.9	18.5	53.4	0.0	0.2	19.0	6.2	8.7	71.4	58.3	3.4	9.2	2.9	17,685	5,720	1,499	373	1,130	1,317	1,241	+3323
9	Ray Allen R. Allen	445	11,925	39.3	26.8	4.7	4.1	1.3	0.2	9.3	19.0	49.0	3.4	7.7	44.9	4.7	5.2	90.5	62.9	1.1	3.5	2.4	17,499	2,080	1,815	592	88	1,070	990	+1806
10	Antawn Jamison A. Jamison	429	11,160	40.3	26.0	9.1	1.9	1.1	0.4	9.9	20.0	49.7	1.4	3.6	39.2	4.7	6.2	76.1	57.1	3.1	6.0	1.9	17,273	3,915	812	477	173	813	1,117	+153
11	Shaquille O'Neal S. O'Neal	426	11,961	37.6	28.1	11.7	3.1	0.5	2.4	11.0	18.3	60.2	0.0	0.0	0.0	6.0	11.2	53.7	60.3	3.8	7.9	2.8	16,031	4,988	1,310	231	1,023	1,203	1,451	+2943
12	LeBron James L. James	383	11,650	41.4	30.4	7.3	6.7	1.8	0.9	10.9	22.1	49.1	1.6	4.5	34.6	7.1	9.6	74.6	57.7	1.3	6.0	3.3	15,860	2,803	2,575	702	337	1,262	786	+1841
13	Elton Brand E. Brand	338	8,496	39.9	25.1	10.6	2.7	1.0	2.3	9.7	17.4	55.4	0.0	0.0	20.0	5.8	7.6	76.0	60.4	3.9	6.7	2.6	13,502	3,568	906	341	765	869	1,076	+339
14	Carmelo Anthony C. Anthony	325	9,056	37.6	27.9	6.3	3.3	1.2	0.5	10.0	20.4	49.1	0.8	2.4	33.2	7.1	8.8	80.5	57.5	2.0	4.3	3.1	12,225	2,047	1,057	402	153	1,009	1,000	+1202
15	Stephon Marbury S. Marbury	322	8,725	41.0	27.1	3.4	7.9	1.4	0.1	9.6	19.6	48.9	1.7	4.4	38.0	6.3	7.7	81.7	59.0	0.8	2.6	3.3	13,192	1,096	2,543	442	47	1,051	796	+106
16	Chris Webber C. Webber	307	8,037	40.2	26.2	10.7	4.8	1.6	1.4	10.8	21.9	49.3	0.2	0.7	28.2	4.3	5.9	73.4	53.3	2.6	8.1	2.9	12,343	3,272	1,471	477	439	884	1,003	+1301
17	Michael Redd M. Redd	306	8,226	38.6	26.9	4.5	2.7	1.1	0.1	9.3	19.4	47.8	2.2	5.4	41.3	6.1	7.1	85.7	59.6	1.1	3.4	2.0	11,799	1,381	825	334	38	600	577	+419
18	Peja Stojakovic P. Stojakovic	304	7,731	39.4	25.4	5.7	2.1	1.2	0.2	8.9	17.1	51.9	3.2	6.6	47.8	4.5	5.0	91.0	66.0	1.1	4.6	1.6	11,963	1,719	630	361	48	477	628	+2168
19	Shawn Marion S. Marion	302	7,419	40.7	24.6	10.8	2.1	2.1	1.4	9.8	18.4	53.2	1.5	3.7	40.2	3.5	4.1	85.5	60.8	2.9	8.0	1.7	12,280	3,276	642	622	428	508	793	+1676
20	Richard Hamilton R. Hamilton	299	7,469	37.5	25.0	3.8	3.8	0.9	0.2	9.4	18.3	51.2	0.7	1.7	40.2	5.5	6.3	87.7	59.2	1.1	2.7	2.4	11,209	1,122	1,137	269	58	707	866	+1576
21	Rashard Lewis R. Lewis	296	7,323	39.0	24.7	6.4	2.2	1.3	0.6	8.8	16.9	52.3	2.8	6.0	47.2	4.2	5.2	81.2	64.4	1.8	4.6	1.7	11,542	1,900	642	391	183	516	737	+1493
22	Dwyane Wade D. Wade	283	8,371	39.8	29.6	5.1	7.1	1.9	1.1	10.3	20.3	50.7	0.6	1.8	31.1	8.4	10.6	78.7	59.1	1.3	3.8	3.8	11,270	1,452	2,019	549	308	1,074	736	+1161
23	Jason Terry J. Terry	278	6,812	39.1	24.5	3.3	5.3	1.6	0.2	8.9	17.4	51.5	2.6	5.8	45.0	4.0	4.7	85.3	63.1	0.6	2.7	2.3	10,859	912	1,472	440	65	628	623	+864
24	Gilbert Arenas G. Arenas	267	7,894	41.1	29.6	4.5	5.8	1.9	0.2	9.5	20.7	45.9	2.8	7.2	39.4	7.8	9.5	82.1	59.5	0.9	3.5	3.5	10,984	1,195	1,549	508	62	930	911	+696
25	Jerry Stackhouse J. Stackhouse	266	7,229	38.4	27.2	3.9	4.7	1.1	0.5	8.9	19.8	44.7	1.7	4.5	36.9	7.8	9.1	85.8	57.1	1.2	2.8	3.4	10,218	1,047	1,251	302	127	896	542	+615