Since 1979-80, Shaquille O'Neal has the most games by a center with 40+ points, with 49 games.

Interpreted as:

most 40 or more point regular-season game by center since 1980

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Shaquille O'Neal S. O'Neal	49	2,102	40.6	42.9	13.6	2.5	0.8	2.2	16.9	25.6	66.1	0.0	0.0	0.0	9.1	15.2	60.1	66.5	5.1	8.5	2.7	1,991	668	122	41	108	132	145	+319
2	Joel Embiid J. Embiid	48	2,134	36.2	44.5	13.4	4.4	1.3	2.0	15.0	24.8	60.5	1.5	3.8	38.0	13.0	15.0	86.7	70.8	2.9	10.5	3.3	1,736	641	213	60	97	157	156	+533
3	Hakeem Olajuwon H. Olajuwon	32	1,371	43.3	42.8	13.1	3.4	1.9	3.3	16.4	27.2	60.2	0.1	0.3	25.0	10.0	12.5	80.5	65.5	3.6	9.5	3.7	1,385	420	110	61	107	119	111	+18
4	Nikola Jokić N. Jokić	30	1,315	38.8	43.8	12.3	7.9	1.9	1.0	16.7	27.2	61.2	2.6	5.8	44.0	7.9	9.7	82.1	69.6	3.5	8.8	3.2	1,164	368	236	56	30	96	87	+292
5	Patrick Ewing P. Ewing	29	1,241	40.4	42.8	12.9	2.2	1.1	3.4	17.1	26.0	65.8	0.0	0.1	33.3	8.5	10.4	81.5	69.9	3.8	9.1	3.4	1,171	373	65	31	98	98	109
6	Moses Malone M. Malone	25	1,106	42.7	44.2	16.7	1.5		1.8	16.0	26.7	60.0	0.0			12.2	14.9	82.3	66.6				1,068	417	37		44		69
7	David Robinson D. Robinson	22	980	42.8	44.5	12.4	3.5	1.9	4.4	16.0	25.6	62.5	0.1	0.5	27.3	12.4	15.3	81.3	68.9	3.5	8.8	3.5	942	272	78	42	97	77	67
8	Karl-Anthony Towns K. Towns	18	808	37.7	44.9	13.3	3.7	1.2	0.5	16.2	26.7	60.8	4.1	7.2	56.6	8.4	10.3	81.2	71.9	3.5	9.8	3.4	679	239	66	21	9	62	62	+115
9	Anthony Davis A. Davis	15	653	39.4	43.5	13.8	3.2	1.9	1.9	16.1	28.3	56.7	1.3	3.2	39.6	10.1	11.9	85.4	64.9	3.7	10.1	1.3	591	207	48	28	28	20	41	+124
10	Amar'e Stoudemire A. Stoudemire	14	594	39.4	42.4	10.6	2.7	1.0	1.5	15.3	23.7	64.5	0.1	0.4	20.0	11.8	14.1	83.3	70.9	4.4	6.2	2.4	551	148	38	14	21	34	56	+109
11	DeMarcus Cousins D. Cousins	13	574	39.5	44.2	15.8	4.0	1.5	1.5	14.8	26.3	56.4	2.5	5.5	45.1	12.0	15.0	80.0	67.1	3.9	11.8	4.5	514	205	52	20	20	58	57	+89
12	Chris Bosh C. Bosh	9	371	41.2	41.2	10.2	3.0	1.4	0.3	13.3	22.7	58.8	0.3	0.7	50.0	14.2	16.2	87.7	69.2	3.7	6.6	2.1	371	92	27	13	3	19	20	+52
13	Kareem Abdul-Jabbar K. Abdul-Jabbar	8	334	42.9	41.8	11.1	3.8		3.0	16.6	27.0	61.6	0.0	0.0		8.5	10.8	79.1	65.8				343	89	30		24		24
14	Jaren Jackson Jr. J. Jackson Jr.	5	207	38.3	41.4	6.2	2.4	2.4	2.2	14.2	25.8	55.0	3.8	7.6	50.0	9.2	10.4	88.5	68.1	1.6	4.6	2.6	192	31	12	12	11	13	16	-23
15	Nikola Vučević N. Vučević	5	209	36.0	41.8	13.2	3.6	1.4	0.2	17.2	25.8	66.7	4.6	8.4	54.8	2.8	3.4	82.4	76.6	2.2	11.0	1.4	180	66	18	7	1	7	12	+51
16	Dwight Howard D. Howard	4	170	43.7	42.5	18.0	1.3	2.8	4.8	14.5	21.0	69.0	0.0	0.0		13.5	21.3	63.5	70.0	6.5	11.5	4.0	175	72	5	11	19	16	10	+41
17	Al Jefferson A. Jefferson	4	160	39.6	40.0	15.0	3.5	1.0	0.8	17.0	26.3	64.8	0.0	0.0		6.0	7.5	80.0	67.7	4.5	10.5	3.0	158	60	14	4	3	12	9	+20
18	Alonzo Mourning A. Mourning	4	178	38.5	44.5	13.0	1.0	0.8	4.5	15.8	22.8	69.2	0.0	0.0		13.0	17.8	73.2	72.8	5.0	8.0	3.5	154	52	4	3	18	14	15	+6
19	Joe Barry Carroll J. Barry Carroll	4	181	46.3	45.3	16.3	2.3	2.3	2.5	17.0	30.5	55.7	0.0	0.0		11.3	15.5	72.6	60.6	6.3	10.0	3.5	185	65	9	9	10	14	13
20	Victor Wembanyama V. Wembanyama	3	134	36.7	44.7	10.0	3.7	1.3	3.7	15.7	28.0	56.0	7.0	15.7	44.7	6.3	8.3	76.0	70.5	1.0	9.0	3.3	110	30	11	4	11	10	4	+37
21	Dirk Nowitzki D. Nowitzki	3	123	43.7	41.0	7.7	2.0	2.3	1.0	14.3	22.7	63.2	5.7	10.0	56.7	6.7	8.7	76.9	77.4	0.3	7.3	2.3	131	23	6	7	3	7	6	+18
22	Rik Smits R. Smits	3	124	36.3	41.3	10.0	1.7	2.0	1.3	18.0	27.0	66.7	0.0	0.0		5.3	6.7	80.0	69.0	2.7	7.3	3.0	109	30	5	6	4	9	4	+13
23	Myles Turner M. Turner	2	80	40.3	40.0	10.0	1.0	0.5	2.0	14.0	18.5	75.7	6.5	9.5	68.4	5.5	7.5	73.3	91.7	4.0	6.0	3.0	81	20	2	1	4	6	8	+12
24	LaMarcus Aldridge L. Aldridge	2	104	43.0	52.0	11.0	5.0	0.0	2.5	20.0	32.0	62.5	0.5	0.5	100.0	11.5	12.0	95.8	69.7	3.5	7.5	4.0	86	22	10	0	5	8	7	+30
25	Pau Gasol P. Gasol	2	89	41.7	44.5	14.5	3.0	1.0	0.5	17.0	27.5	61.8	0.0	0.0		10.5	12.5	84.0	67.4	6.0	8.5	3.0	83	29	6	2	1	6	5	+7