Between the 1999-00 and 2008-09 seasons, Kobe Bryant had the most games with 40+ points, with 96 games.

Interpreted as:

most 40 or more point regular-season games by a player in the 2000s

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Kobe Bryant K. Bryant	96	4,396	43.2	45.8	6.2	4.1	1.8	0.7	15.5	30.5	50.8	3.0	6.7	44.9	11.8	13.7	86.1	62.7	1.2	4.9	3.1	4,149	591	392	171	63	299	274	+678
2	Allen Iverson A. Iverson	71	3,159	44.9	44.5	4.2	6.2	2.4	0.2	15.6	30.5	51.0	1.8	4.6	39.7	11.5	13.7	84.2	60.9	0.9	3.3	3.6	3,188	300	439	172	13	257	153	+502
3	Tracy McGrady T. McGrady	45	1,987	41.8	44.2	7.7	5.1	1.7	0.9	15.7	29.5	53.4	3.5	7.4	47.1	9.2	11.9	77.4	63.6	1.8	5.9	2.9	1,880	347	228	78	41	129	88	+219
4	LeBron James L. James	33	1,493	44.1	45.2	7.9	7.2	2.0	0.8	15.5	27.7	56.0	3.3	6.9	47.6	11.0	13.6	80.8	67.2	1.5	6.4	3.8	1,454	261	236	67	26	127	77	+245
5	Vince Carter V. Carter	31	1,348	42.7	43.5	7.6	4.4	1.7	1.0	15.0	27.6	54.3	4.0	7.5	53.2	9.5	11.3	84.3	66.7	2.4	5.2	2.8	1,325	236	136	52	30	88	100	+251
6	Gilbert Arenas G. Arenas	28	1,232	42.7	44.0	4.1	5.4	2.0	0.2	13.6	25.5	53.5	4.7	9.6	48.9	12.0	14.4	83.6	69.1	1.0	3.1	3.9	1,195	114	152	56	6	109	95	+145
7	Dwyane Wade D. Wade	24	1,050	42.9	43.8	6.1	7.3	2.7	1.7	15.2	26.4	57.4	1.7	3.8	45.6	11.7	14.2	82.4	67.0	1.4	4.7	4.3	1,030	146	174	65	40	104	57	+134
8	Shaquille O'Neal S. O'Neal	23	978	40.1	42.5	13.3	3.0	0.8	2.0	16.3	24.0	67.9	0.0	0.0		9.9	16.6	59.7	67.9	4.5	8.8	2.7	922	306	70	18	46	62	76	+243
9	Paul Pierce P. Pierce	19	811	43.3	42.7	7.2	3.4	2.4	1.1	13.3	25.1	52.8	2.8	6.3	45.4	13.3	16.1	83.0	66.3	1.2	6.1	3.7	823	137	64	45	21	71	53	+133
10	Stephon Marbury S. Marbury	14	592	43.5	42.3	4.4	7.9	1.6	0.1	14.8	25.5	58.0	3.6	6.9	52.1	9.1	10.8	84.8	69.9	1.3	3.1	3.1	609	62	111	22	1	44	40	+52
11	Amar'e Stoudemire A. Stoudemire	13	562	40.0	43.2	11.4	2.8	1.4	1.3	15.2	22.7	67.1	0.0	0.3	0.0	12.8	15.2	84.3	73.6	4.4	7.0	2.2	520	148	37	18	17	29	48	+166
12	Dirk Nowitzki D. Nowitzki	12	526	43.9	43.8	10.3	2.6	1.4	1.3	14.6	26.4	55.2	3.0	5.9	50.7	11.7	12.9	90.3	68.3	1.8	8.5	2.6	526	124	31	17	16	31	22	+94
13	Ray Allen R. Allen	12	515	43.3	42.9	5.8	4.3	1.6	0.2	14.7	24.8	59.3	6.5	11.8	55.3	7.1	7.8	91.4	76.2	1.2	4.6	2.7	520	69	51	19	2	32	25	+87
14	Michael Redd M. Redd	11	486	43.4	44.2	5.4	3.1	1.8	0.2	15.0	27.1	55.4	4.5	8.1	55.1	9.7	10.9	89.2	69.3	2.0	3.4	2.1	477	59	34	20	2	23	28	+28
15	Carmelo Anthony C. Anthony	10	437	41.8	43.7	7.9	2.2	2.3	0.6	16.4	27.1	60.5	1.8	3.0	60.0	9.1	10.8	84.3	68.6	2.5	5.4	2.9	418	79	22	23	6	29	38	+62
16	Jerry Stackhouse J. Stackhouse	10	435	42.8	43.5	3.0	3.7	1.1	0.5	14.7	27.9	52.7	3.0	7.2	41.7	11.1	12.7	87.4	64.9	0.3	2.7	4.3	428	30	37	11	5	43	20	+56
17	Jamal Crawford J. Crawford	8	358	45.5	44.8	3.4	4.4	1.3	0.8	15.6	27.3	57.3	5.4	9.6	55.8	8.1	9.3	87.8	71.4	0.8	2.6	2.6	364	27	35	10	6	21	16	+62
18	Michael Jordan M. Jordan	8	350	42.3	43.8	7.6	4.5	2.4	0.3	17.4	31.4	55.4	0.6	1.4	45.5	8.4	10.0	83.8	61.1	1.5	6.1	1.8	338	61	36	19	2	14	18	+104
19	Antawn Jamison A. Jamison	8	356	45.8	44.5	10.9	1.9	1.3	0.6	17.0	27.1	62.7	2.3	4.4	51.4	8.3	11.0	75.0	69.6	4.6	6.3	1.5	367	87	15	10	5	12	19	-1
20	Chris Bosh C. Bosh	7	286	41.8	40.9	9.7	3.4	1.0	0.4	13.1	23.1	56.8	0.3	0.3	100.0	14.3	16.4	87.0	67.3	3.9	5.9	2.0	293	68	24	7	3	14	14	+43
21	Jason Richardson J. Richardson	7	290	41.9	41.4	5.4	4.0	2.0	0.6	16.1	28.0	57.7	3.9	8.4	45.8	5.3	6.9	77.1	66.8	1.6	3.9	2.3	293	38	28	14	4	16	18	+33
22	Gary Payton G. Payton	6	251	44.2	41.8	5.8	8.0	2.5	0.2	16.7	27.7	60.2	2.2	4.8	44.8	6.3	8.0	79.2	67.1	1.2	4.7	1.2	265	35	48	15	1	7	17	+58
23	Chris Paul C. Paul	5	210	43.8	42.0	5.6	8.6	4.4	0.0	16.0	27.6	58.0	4.2	7.8	53.8	5.8	6.6	87.9	68.8	1.2	4.4	2.2	219	28	43	22	0	11	13	+23
24	Kevin Martin K. Martin	5	226	43.9	45.2	5.0	3.2	0.8	0.2	12.0	22.6	53.1	4.6	9.0	51.1	16.6	18.4	90.2	73.6	1.2	3.8	3.2	220	25	16	4	1	16	14	0
25	Joe Johnson J. Johnson	5	203	46.7	40.6	2.8	8.8	1.4	0.0	15.8	26.2	60.3	4.4	6.0	73.3	4.6	5.0	92.0	71.5	1.0	1.8	3.2	233	14	44	7	0	16	16	+22