Wilt Chamberlain had the most games with 46+ points, with 161 games.

Interpreted as:

most 46 or more point regular-season games by a player in NBA history

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	161	8,809		54.7	25.8				22.2	40.4	55.1				10.2	17.1	59.8	57.1					4,160					293
2	Michael Jordan M. Jordan	60	3,056	41.9	50.9	7.1	4.7	3.0	1.2	18.9	31.9	59.3	0.9	2.2	39.4	12.3	14.1	87.3	66.9	2.0	5.1	3.1	2,516	423	284	179	73	187	176	+66
3	Kobe Bryant K. Bryant	37	1,942	43.6	52.5	6.2	3.5	1.7	0.6	17.9	33.8	53.1	3.7	8.2	45.2	12.9	14.6	88.3	65.3	0.9	5.3	2.9	1,612	228	128	62	21	108	102	+367
4	James Harden J. Harden	36	1,883	40.1	52.3	7.1	7.5	2.2	0.6	15.5	29.1	53.3	6.5	14.0	46.5	14.8	16.4	89.7	72.0	1.3	5.9	5.0	1,445	256	269	78	22	181	113	+431
5	Stephen Curry S. Curry	33	1,648	37.1	49.9	5.1	5.4	1.6	0.3	16.3	27.7	58.9	9.5	16.6	57.0	7.9	8.4	93.9	79.6	0.5	4.6	3.1	1,224	169	179	53	9	101	67	+332
6	Elgin Baylor E. Baylor	33	1,688		51.2					19.0						13.2	16.6	79.6											122
7	Allen Iverson A. Iverson	27	1,331	45.5	49.3	4.7	6.2	2.5	0.2	17.1	32.1	53.2	2.6	5.9	44.3	12.6	15.0	83.5	63.6	1.0	3.7	4.2	1,230	127	168	68	5	113	71	+130
8	LeBron James L. James	25	1,259	41.9	50.4	8.0	6.9	1.6	0.8	17.4	28.6	60.7	5.0	8.9	55.6	10.7	12.8	83.4	73.6	1.4	6.6	3.2	1,047	200	173	39	20	80	48	+198
9	Rick Barry R. Barry	25	1,266	44.1	50.6	8.7	5.0	3.0		19.2	37.8	50.6				12.3	13.6	90.9	57.8	1.0	6.5	2.0	1,103	217	124	24		4	83
10	George Gervin G. Gervin	20	978	40.3	48.9	5.0	2.9	1.6	0.9	19.0	31.4	60.4	0.3	1.1	25.0	10.8	12.5	86.7	66.4				806	100	58	32	18		48
11	Giannis Antetokounmpo G. Antetokounmpo	18	914	36.6	50.8	12.8	4.6	1.3	0.9	18.4	27.8	66.2	1.6	4.3	37.7	12.4	16.1	77.2	72.9	2.7	10.2	2.9	659	231	83	24	16	53	43	+180
12	Damian Lillard D. Lillard	18	970	39.4	53.9	4.6	7.4	1.3	0.2	16.8	28.9	58.1	7.8	14.2	54.7	12.6	13.3	94.6	77.6	0.4	4.1	2.5	709	82	134	24	4	45	24	+189
13	Kareem Abdul-Jabbar K. Abdul-Jabbar	18	898		49.9	14.8	4.3	0.3	1.8	19.9	31.4	63.4	0.0	0.0		10.1	13.6	74.3	66.7			6.0		267	77	1	7	6
14	Dominique Wilkins D. Wilkins	17	848	42.8	49.9	7.2	2.9	2.2	0.6	17.8	31.6	56.2	1.1	2.2	48.6	13.3	15.5	85.9	65.0	3.2	3.9	3.5	728	122	49	37	10	59	38
15	Devin Booker D. Booker	16	833	39.2	52.1	5.5	6.0	1.3	0.4	18.6	30.8	60.6	4.6	9.6	47.4	10.3	11.6	88.6	72.6	0.9	4.6	3.1	627	88	96	20	7	49	43	+105
16	Kevin Durant K. Durant	16	799	43.9	49.9	8.3	5.2	1.6	0.9	16.2	29.7	54.5	4.8	9.3	51.0	12.8	14.3	89.9	69.4	0.8	7.5	3.4	702	132	83	25	14	55	39	+60
17	Larry Bird L. Bird	16	785	42.9	49.1	10.9	6.4	1.7	0.8	18.9	31.3	60.6	1.2	3.2	37.3	10.0	10.8	92.5	68.1	2.5	8.4	3.8	686	175	102	27	12	61	39
18	Jerry West J. West	16	785		49.1					18.1	30.8	58.9				12.8	15.4	83.0	65.3
19	Bob Pettit B. Pettit	15	743		49.5					18.5	33.6	55.2				12.5	15.0	83.1	61.6										55
20	Joel Embiid J. Embiid	14	719	35.4	51.4	13.2	4.9	1.4	2.5	17.8	27.4	64.8	1.1	3.2	35.6	14.6	16.4	89.1	74.1	3.5	9.7	3.0	495	185	69	20	35	42	41	+210
21	Russell Westbrook R. Westbrook	13	651	39.6	50.1	10.9	8.6	2.1	0.2	17.2	34.4	50.1	3.4	9.6	35.2	12.2	14.6	83.7	61.3	2.0	8.9	4.8	515	142	112	27	3	63	42	+19
22	Tracy McGrady T. McGrady	13	641	42.4	49.3	8.2	5.3	1.8	1.0	17.4	31.2	55.8	4.3	8.6	50.0	10.2	13.8	73.9	66.2	2.0	6.2	3.2	552	107	69	23	13	42	31	+93
23	Bernard King B. King	13	653	41.4	50.2	7.9	3.8	1.4	0.2	19.0	30.3	62.7	0.0	0.3	0.0	12.2	15.2	80.3	67.9	3.2	4.7	3.5	538	103	49	18	3	45	45
24	Adrian Dantley A. Dantley	13	643	42.5	49.5	7.3	4.4		0.1	17.0	23.8	71.5	0.0	0.2	0.0	15.5	17.6	87.8	78.5			3.2	553	95	57		1	41	42
25	Luka Dončić L. Dončić	12	628	39.6	52.3	10.3	8.7	1.7	0.7	17.7	28.4	62.2	6.4	12.2	52.7	10.6	13.7	77.4	76.0	0.9	9.4	3.8	475	124	104	20	8	45	33	+133