James Harden and Paul Pierce are tied for the most points in a game versus LeBron James, with 50 points.

most points scored against lebron james in a game

Interpreted as:

most points by a player scored against LeBron James in a regular-season game

NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	TOV	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	PF	+/-
James Harden	50	12/13/2018	HOU	vs	LAL	35	10	11	2	0	6	14	26	53.8	4	12	33.3	18	19	94.7	4	+14
Paul Pierce	50	2/15/2006	BOS	vs	CLE	54	7	8	0	0	4	17	36	47.2	0	4	0.0	16	20	80.0	6	-1
Damian Lillard	48	1/31/2020	POR	@	LAL	40	9	10	2	0	1	17	30	56.7	7	12	58.3	7	8	87.5	1	+12
Stephen Curry	46	1/27/2024	GSW	vs	LAL	43	3	7	1	0	4	17	35	48.6	9	21	42.9	3	3	100.0	4	-2
Paul Millsap	46	11/9/2010	UTA	@	MIA	43	9	1	1	1	1	19	28	67.9	3	3	100.0	5	7	71.4	4	+2
Manu Ginobili	46	2/13/2008	SAS	@	CLE	41	5	8	3	1	1	15	20	75.0	8	11	72.7	8	9	88.9	2	+12
Victor Oladipo	45	3/18/2016	ORL	vs	CLE	39	5	3	3	2	3	16	22	72.7	6	7	85.7	7	8	87.5	3	-1
Gilbert Arenas	45	11/18/2006	WAS	vs	CLE	39	5	6	2	0	1	14	22	63.6	7	11	63.6	10	12	83.3	2	+26
De'Aaron Fox	44	3/6/2024	SAC	@	LAL	39	4	4	2	0	3	19	32	59.4	2	6	33.3	4	5	80.0	3	+5
Jayson Tatum	44	12/13/2022	BOS	@	LAL	44	9	6	0	1	4	15	29	51.7	5	10	50.0	9	10	90.0	1	+12
Giannis Antetokounmpo	44	2/8/2022	MIL	@	LAL	35	14	8	1	2	0	17	20	85.0	2	2	100.0	8	13	61.5	5	+23
Dwyane Wade	44	4/1/2006	MIA	@	CLE	43	8	9	2	1	1	18	36	50.0	1	4	25.0	7	9	77.8	4	-1
Richard Hamilton	44	11/28/2003	DET	vs	CLE	39	7	5	1	0	2	15	23	65.2	1	1	100.0	13	15	86.7	3	+8
Donovan Mitchell	43	12/6/2022	CLE	vs	LAL	40	6	5	4	0	2	17	27	63.0	4	8	50.0	5	5	100.0	1	+21
Paul George	43	4/2/2017	IND	@	CLE	48	9	9	3	1	3	16	33	48.5	6	16	37.5	5	7	71.4	5	+17
Kyle Lowry	43	2/26/2016	TOR	vs	CLE	43	5	9	4	0	2	15	20	75.0	2	5	40.0	11	15	73.3	4	+11
Blake Griffin	43	2/5/2014	LAC	vs	MIA	42	15	6	0	0	4	16	34	47.1	1	3	33.3	10	17	58.8	5	+5
Jeff Green	43	3/18/2013	BOS	vs	MIA	40	7	2	2	4	2	14	21	66.7	5	7	71.4	10	13	76.9	2	+3
Shareef Abdur-Rahim	43	12/6/2003	ATL	@	CLE	43	12	2	1	0	4	17	27	63.0	0	1	0.0	9	10	90.0	4	-8
Carmelo Anthony	42	4/15/2012	NYK	vs	MIA	43	9	5	1	0	1	14	27	51.9	2	7	28.6	12	15	80.0	4	-13
Dwyane Wade	42	1/21/2008	MIA	vs	CLE	40	6	7	3	1	4	17	29	58.6	1	3	33.3	7	8	87.5	3	-7
Richard Jefferson	42	12/22/2004	NJN	vs	CLE	47	6	7	1	1	3	12	20	60.0	2	4	50.0	16	17	94.1	1	+4
Miles Bridges	41	2/5/2024	CHA	vs	LAL	40	0	4	0	0	1	16	26	61.5	5	10	50.0	4	4	100.0	1	-4
Damian Lillard	41	10/23/2022	POR	@	LAL	34	5	2	0	1	6	15	25	60.0	6	13	46.2	5	7	71.4	3	+2
Ja Morant	41	12/29/2021	MEM	vs	LAL	36	10	2	2	2	6	13	27	48.1	6	7	85.7	9	12	75.0	4	+3