Wilt Chamberlain has put up the most points in a loss, with 78 points versus the Lakers on December 8, 1961.

most points scored by a player in a game in a loss

Interpreted as:

most points scored by a player in a game in a regular-season loss

NAME	PTS	L	DATE	TM		OPP	MIN	REB	AST	STL	BLK	TOV	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	PF	+/-
Wilt Chamberlain	78	1	12/8/1961	PHI	vs	LAL	63	43	1				31	62	50.0				16	31	51.6	4
David Thompson	73	1	4/9/1978	DEN	@	DET	43	7	2	0	1	4	28	38	73.7				17	20	85.0	2
Wilt Chamberlain	72	1	11/3/1962	SFW	@	LAL	48	18	1				29	48	60.4				14	18	77.8	0
Devin Booker	70	1	3/24/2017	PHX	@	BOS	45	8	6	3	1	5	21	40	52.5	4	11	36.4	24	26	92.3	3	-6
Wilt Chamberlain	70	1	3/10/1963	SFW	@	SYR	48	18	3				27	38	71.1				16	22	72.7	2
Wilt Chamberlain	67	1	1/11/1963	SFW	vs	LAL	48	25	1				28	47	59.6				11	17	64.7	1
Wilt Chamberlain	67	1	2/25/1962	PHI	vs	NYK	48	21	1				25	38	65.8				17	22	77.3	1
Wilt Chamberlain	67	1	2/17/1962	PHI	@	STL	48	28	2				26	44	59.1				15	20	75.0	1
Wilt Chamberlain	65	1	2/13/1962	PHI	@	CIN	48	22	4				24	40	60.0				17	30	56.7	3
Michael Jordan	64	1	1/16/1993	CHI	vs	ORL	47	6	1	5	0	2	27	49	55.1	1	5	20.0	9	11	81.8	5
George Gervin	63	1	4/9/1978	SAS	@	NOJ	33	2	1	2	1		23	49	46.9				17	20	85.0	3
Wilt Chamberlain	63	1	11/26/1964	SFW	@	PHI	48	32	3				27	58	46.6				9	20	45.0	2
Wilt Chamberlain	63	1	12/14/1962	SFW	vs	LAL	48	30	1				24	41	58.5				15	20	75.0	4
Devin Booker	62	1	1/26/2024	PHX	@	IND	38	5	4	1	2	4	22	37	59.5	6	12	50.0	12	13	92.3	2	+1
Karl-Anthony Towns	62	1	1/22/2024	MIN	vs	CHA	38	8	2	0	0	7	21	35	60.0	10	15	66.7	10	14	71.4	2	0
Wilt Chamberlain	62	1	1/14/1962	PHI	@	BOS	48	28	2				27	45	60.0				8	11	72.7	1
Jalen Brunson	61	1	3/29/2024	NYK	@	SAS	43	4	6	1	0	1	25	47	53.2	5	13	38.5	6	6	100.0	2	+20
Michael Jordan	61	1	4/16/1987	CHI	vs	ATL	41	10	1	4	1	3	22	38	57.9	0	3	0.0	17	21	81.0	3
Wilt Chamberlain	61	1	11/21/1962	SFW	vs	CIN	48	22	3				27	52	51.9				7	15	46.7	3
Stephen Curry	60	1	2/3/2024	GSW	@	ATL	41	6	4	0	1	2	22	38	57.9	10	23	43.5	6	6	100.0	1	-1
Bradley Beal	60	1	1/6/2021	WAS	@	PHI	38	7	5	1	0	4	20	35	57.1	7	10	70.0	13	15	86.7	3	-9
Damian Lillard	60	1	11/8/2019	POR	vs	BKN	40	4	5	0	0	2	19	33	57.6	7	16	43.8	15	15	100.0	1	+4
Kemba Walker	60	1	11/17/2018	CHA	vs	PHI	45	7	4	4	0	9	21	34	61.8	6	14	42.9	12	12	100.0	2	+1
Bernard King	60	1	12/25/1984	NYK	vs	NJN	41	7	4	0	0	5	19	30	63.3	0	0		22	26	84.6	2
Devin Booker	59	1	3/25/2019	PHX	@	UTA	41	4	4	1	0	6	19	34	55.9	5	8	62.5	16	17	94.1	5	-13