Joel Embiid has posted the most points in a game against the Spurs, with 70 points on January 22.

most points scored in a game by opponent against spurs

Interpreted as:

most points by a player scored in a regular-season game by opponent against spurs

NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	TOV	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	PF	+/-
Joel Embiid	70	1/22/2024	PHI	vs	SAS	37	18	5	1	1	1	24	41	58.5	1	2	50.0	21	23	91.3	2	+11
Jalen Brunson	61	3/29/2024	NYK	@	SAS	43	4	6	1	0	1	25	47	53.2	5	13	38.5	6	6	100.0	2	+20
James Harden	61	3/22/2019	HOU	vs	SAS	37	7	1	3	0	3	19	34	55.9	9	13	69.2	14	17	82.4	3	+18
Karl-Anthony Towns	60	3/14/2022	MIN	@	SAS	36	17	3	1	0	6	19	31	61.3	7	11	63.6	15	16	93.8	5	+16
Jayson Tatum	60	4/30/2021	BOS	vs	SAS	45	8	5	0	1	0	20	37	54.1	5	7	71.4	15	17	88.2	2	+6
Kyrie Irving	57	3/12/2015	CLE	@	SAS	47	3	5	4	0	2	20	32	62.5	7	7	100.0	10	10	100.0	3	+6
Purvis Short	57	1/7/1984	GSW	vs	SAS	42	15	1	1	0	3	24	38	63.2	2	2	100.0	7	8	87.5	2
Tyrese Maxey	52	4/7/2024	PHI	@	SAS	54	5	7	2	0	1	19	41	46.3	2	10	20.0	12	12	100.0	2	+14
Ja Morant	52	2/28/2022	MEM	vs	SAS	34	7	2	0	0	4	22	30	73.3	4	4	100.0	4	7	57.1	1	+23
Billy Knight	52	11/11/1980	IND	@	SAS	39	5	0	5	0		19	30	63.3	0	0		14	16	87.5	1
Luka Doncic	51	12/31/2022	DAL	@	SAS	37	6	9	4	1	0	18	29	62.1	6	10	60.0	9	15	60.0	3	+7
James Harden	50	12/3/2019	HOU	@	SAS	49	9	6	4	0	5	11	37	29.7	4	20	20.0	24	24	100.0	4	-3
Bernard King	50	1/31/1984	NYK	@	SAS	44	8	2	0	0	1	20	30	66.7	0	0		10	13	76.9	5
Kiki VanDeWeghe	50	1/11/1984	DEN	vs	SAS	34	4	2	1	1	1	21	30	70.0	1	1	100.0	7	7	100.0	1
Anthony Edwards	49	4/7/2022	MIN	vs	SAS	39	6	8	1	0	2	16	28	57.1	6	14	42.9	11	14	78.6	2	+18
Devin Booker	48	1/17/2022	PHX	@	SAS	35	5	6	3	0	0	18	33	54.5	5	13	38.5	7	8	87.5	2	+3
Clyde Drexler	48	11/24/1991	POR	vs	SAS	40	6	3	6	3	1	17	28	60.7	3	7	42.9	11	13	84.6	2
Dominique Wilkins	48	1/13/1988	ATL	@	SAS	42	11	4	2	0	3	15	27	55.6	0	0		18	18	100.0	2
Hakeem Olajuwon	47	1/13/1995	HOU	vs	SAS	45	10	4	1	3	7	21	35	60.0	0	0		5	7	71.4	4
Dale Ellis	47	1/9/1988	SEA	vs	SAS	43	7	8	1	0	2	18	31	58.1	2	5	40.0	9	10	90.0	4
Adrian Dantley	47	3/14/1986	UTA	vs	SAS	39	3	8	2	0	4	20	26	76.9	0	2	0.0	7	10	70.0	4
Allen Iverson	46	2/12/1999	PHI	vs	SAS	40	7	6	1	0	3	14	26	53.8	3	6	50.0	15	17	88.2	3	-4
Isiah Thomas	46	2/8/1983	DET	@	SAS	46	10	11	4	0	1	14	24	58.3	3	5	60.0	15	18	83.3	2
Alperen Sengun	45	3/5/2024	HOU	vs	SAS	37	16	3	5	1	2	19	32	59.4	2	3	66.7	5	7	71.4	3	+18
Trae Young	45	11/30/2023	ATL	@	SAS	40	4	14	2	0	2	15	29	51.7	2	9	22.2	13	16	81.3	1	-1