Stephen Curry has the highest plus-minus this season, at +254.

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nba leaders in plus minus
Interpreted as:
NBA leaders in plus minus this regular season
2021-22Curry2021-22Antetokounmpo2021-22Mills2021-22Towns2021-22Russell2021-22Kennard2021-22DeRozan2021-22Clarkson2021-22Paul2021-22Bridges2021-22Hill2021-22Durant2021-22Herro2021-22Poole2021-22Harden2021-22Bjelica2021-22Bridges2021-22Payton2021-22Edwards2021-22Gobert2021-22Tatum2021-22Wiggins2021-22Rose2021-22Mitchell2021-22Allen+254+225+195+191+186+184+181+179+175+173+172+170+169+167+164+164+163+160+160+158+155+154+154+154+154
NAMESEASONTMGP+/-MPGPPGRPGAPGSPGBPGTPGFGMFGAFG%3PM3PA3P%FTMFTAFT%MINPTSREBASTSTLBLKTOVPF
Stephen CurryStephen Curry2021-22GSWGSW15+25433.627.95.37.11.70.53.18.919.844.85.413.141.34.85.194.7504419801062684625
Giannis AntetokounmpoGiannis Antetokounmpo2021-22MILMIL12+22532.528.512.56.80.92.52.99.818.553.21.33.931.97.610.373.43903421508111303533
Patty MillsPatty Mills2021-22BKNBKN13+19527.615.21.52.40.60.20.75.410.153.44.17.157.60.30.3100.0359197193182922
Karl-Anthony TownsKarl-Anthony Towns2021-22MINMIN11+19133.324.18.03.51.01.62.98.816.752.72.75.846.93.74.387.2366265883911183237
D'Angelo RussellD'Angelo Russell2021-22MINMIN11+18630.218.23.55.50.70.73.06.216.038.62.88.533.33.03.976.73322003961883320
Luke KennardLuke Kennard2021-22LACLAC13+18426.510.03.32.20.60.20.53.57.845.52.55.247.80.50.5100.0345130432882618
DeMar DeRozanDeMar DeRozan2021-22CHICHI14+18135.627.45.94.40.80.52.49.919.650.50.92.734.26.67.588.649838482611173330
Jordan ClarksonJordan Clarkson2021-22UTAUTA12+17925.318.03.42.50.50.21.46.314.443.92.99.132.12.42.887.93032164130621716
Chris PaulChris Paul2021-22PHXPHX13+17532.215.14.111.22.40.42.45.210.549.61.13.234.13.54.285.2419196531463153129
Mikal BridgesMikal Bridges2021-22PHXPHX15+17333.913.33.91.90.90.70.75.59.855.81.43.638.91.01.188.2509200582914111036
George HillGeorge Hill2021-22MILMIL11+17227.57.94.22.71.00.01.23.06.447.11.12.740.00.80.8100.03028746301101315
Kevin DurantKevin Durant2021-22BKNBKN12+17035.227.57.46.30.70.63.39.817.357.01.64.138.86.37.386.24233308976873919
Tyler HerroTyler Herro2021-22MIAMIA11+16933.023.05.94.50.50.03.08.718.547.32.76.840.02.83.386.13632536550603314
Jordan PooleJordan Poole2021-22GSWGSW13+16730.921.13.53.21.20.22.87.515.548.53.28.737.22.83.190.040227445411523746
James HardenJames Harden2021-22BKNBKN11+16435.223.48.59.91.50.75.06.214.542.82.97.837.28.19.288.1388257931091785526
Nemanja BjelicaNemanja Bjelica2021-22GSWGSW10+16417.69.14.72.41.30.41.23.46.155.71.63.250.00.70.977.81769147241341215
Miles BridgesMiles Bridges2021-22CHACHA12+16336.918.07.74.31.61.01.86.515.342.41.96.429.93.13.978.7443216925119122127
Gary Payton IIGary Payton II2021-22GSWGSW11+16018.38.43.41.11.60.20.43.44.968.50.51.535.31.11.666.7201923712182425
Anthony EdwardsAnthony Edwards2021-22MINMIN11+16035.022.15.63.41.50.93.28.518.944.73.79.638.71.51.880.0385243623717103531
Rudy GobertRudy Gobert2021-22UTAUTA13+15831.215.415.20.80.92.31.75.57.573.50.00.10.04.36.665.14062001981012302231
Jayson TatumJayson Tatum2021-22BOSBOS13+15536.626.88.83.51.00.92.39.422.541.63.28.736.34.85.785.14763481154513123036
Andrew WigginsAndrew Wiggins2021-22GSWGSW13+15429.519.84.31.50.90.51.87.214.549.51.95.237.33.64.777.038425856191262320
Derrick RoseDerrick Rose2021-22NYKNYK11+15423.213.33.53.61.10.31.45.211.047.11.94.344.71.01.191.72561463840123154
Donovan MitchellDonovan Mitchell2021-22UTAUTA12+15432.124.24.24.81.80.32.59.020.543.93.39.534.22.93.583.338629050572233029
Grayson AllenGrayson Allen2021-22MILMIL12+15427.813.83.81.50.50.30.64.510.841.53.27.840.91.61.890.5333165451864717
StatMuse has game-level data for +/- going back to the 1996-97 season.