Between the 1999-00 and 2008-09 seasons, Kobe Bryant scored the most points in a game, with 81 points versus the Raptors on January 22, 2006.

Interpreted as:

NBA most points by a player in a regular-season game 2000s

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Kobe Bryant K. Bryant	81	1/22/2006	LAL	vs	TOR	42	6	2	3	1	28	46	60.9	7	13	53.8	18	20	90.0	73.9	2	4	3	1	+25
2	Kobe Bryant K. Bryant	65	3/16/2007	LAL	vs	POR	50	7	3	3	0	23	39	59.0	8	12	66.7	11	12	91.7	73.4	1	6	2	3	+4
3	Kobe Bryant K. Bryant	62	12/20/2005	LAL	vs	DAL	33	8	0	3	0	18	31	58.1	4	10	40.0	22	25	88.0	73.8	3	5	2	3	+35
4	Tracy McGrady T. McGrady	62	3/10/2004	ORL	vs	WAS	46	10	5	1	0	20	37	54.1	5	14	35.7	17	26	65.4	64.0	3	7	6	1	+10
5	Kobe Bryant K. Bryant	61	2/2/2009	LAL	@	NYK	37	0	3	0	1	19	31	61.3	3	6	50.0	20	20	100.0	76.6	0	0	2	1	+19
6	Shaquille O'Neal S. O'Neal	61	3/6/2000	LAL	@	LAC	45	23	3	0	0	24	35	68.6	0	0		13	22	59.1	68.3	7	16	4	2	+16
7	Kobe Bryant K. Bryant	60	3/22/2007	LAL	@	MEM	45	5	4	0	0	20	37	54.1	3	7	42.9	17	18	94.4	66.8	2	3	2	4	+2
8	Gilbert Arenas G. Arenas	60	12/17/2006	WAS	@	LAL	49	8	8	2	0	17	32	53.1	5	12	41.7	21	27	77.8	68.4	0	8	3	3	+10
9	Allen Iverson A. Iverson	60	2/12/2005	PHI	vs	ORL	42	4	6	5	1	17	36	47.2	2	5	40.0	24	27	88.9	62.7	1	3	3	1	+27
10	Kobe Bryant K. Bryant	58	12/29/2006	LAL	@	CHA	54	5	4	0	0	22	45	48.9	4	11	36.4	10	12	83.3	57.7	0	5	4	6	+5
11	Allen Iverson A. Iverson	58	1/15/2002	PHI	vs	HOU	50	2	6	2	0	21	42	50.0	2	3	66.7	14	14	100.0	60.2	0	2	6	2	+8
12	Michael Redd M. Redd	57	11/11/2006	MIL	vs	UTA	46	2	0	3	1	18	32	56.3	6	12	50.0	15	17	88.2	72.2	0	2	3	2	+2
13	Jerry Stackhouse J. Stackhouse	57	4/3/2001	DET	@	CHI	42	4	5	1	0	21	36	58.3	4	11	36.4	11	13	84.6	68.3	0	4	4	2	+34
14	LeBron James L. James	56	3/20/2005	CLE	@	TOR	48	10	5	2	0	18	36	50.0	6	12	50.0	14	15	93.3	65.7	2	8	4	0	-7
15	Kobe Bryant K. Bryant	56	1/14/2002	LAL	vs	MEM	34	5	4	1	0	21	34	61.8	3	6	50.0	11	12	91.7	71.3	3	2	0	1	+40
16	Dwyane Wade D. Wade	55	4/12/2009	MIA	vs	NYK	39	9	4	0	1	19	30	63.3	6	12	50.0	11	13	84.6	77.0	2	7	3	3	+24
17	LeBron James L. James	55	2/20/2009	CLE	@	MIL	40	5	9	0	0	16	29	55.2	8	11	72.7	15	22	68.2	71.1	1	4	6	3	+13
18	Tony Parker T. Parker	55	11/5/2008	SAS	@	MIN	51	7	10	0	0	22	36	61.1	2	3	66.7	9	10	90.0	68.1	0	7	4	0	+7
19	Jermaine O'Neal J. O'Neal	55	1/4/2005	IND	vs	MIL	36	11	3	0	2	18	28	64.3	0	0		19	25	76.0	70.5	3	8	3	3	+22
20	Kobe Bryant K. Bryant	55	3/28/2003	LAL	vs	WAS	41	5	3	3	0	15	29	51.7	9	13	69.2	16	18	88.9	74.5	0	5	3	5	+21
21	Ray Allen R. Allen	54	1/12/2007	SEA	vs	UTA	43	10	5	1	0	17	32	53.1	8	12	66.7	12	12	100.0	72.4	3	7	2	2	+10
22	Gilbert Arenas G. Arenas	54	12/22/2006	WAS	@	PHX	48	3	4	1	0	21	37	56.8	6	12	50.0	6	6	100.0	68.1	0	3	4	5	+12
23	Damon Stoudamire D. Stoudamire	54	1/14/2005	POR	@	NOH	43	0	1	1	0	20	32	62.5	8	16	50.0	6	6	100.0	77.9	0	0	0	3	-7
24	Allen Iverson A. Iverson	54	12/18/2004	PHI	@	MIL	40	8	5	2	0	17	29	58.6	4	7	57.1	16	21	76.2	70.6	2	6	3	0	+25
25	Allen Iverson A. Iverson	54	1/6/2001	PHI	@	CLE	44	3	3	3	1	20	30	66.7	4	7	57.1	10	13	76.9	75.6	0	3	4	3	+5