Karl-Anthony Towns has averaged 21.9 points, 9.5 rebounds and 2.7 assists in 15 games against the Cavaliers in his career.
| NAME | DATE | TM | OPP | MIN | PTS | REB | AST | STL | BLK | FGM | FGA | FG% | 3PM | 3PA | 3P% | FTM | FTA | FT% | TS% | OREB | DREB | TOV | PF | +/- | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | K. Towns | 1/8/2016 |  MIN | vs |  CLE | 35 | 22 | 6 | 3 | 0 | 0 | 11 | 14 | 78.6 | 0 | 0 | 0 | 0 | 78.6 | 2 | 4 | 2 | 3 | -22 | ||
| 2 | | K. Towns | 1/25/2016 | MIN | @ | CLE | 30 | 26 | 11 | 4 | 1 | 1 | 11 | 16 | 68.8 | 0 | 1 | 0.0 | 4 | 5 | 80.0 | 71.4 | 4 | 7 | 2 | 3 | +4 |
| 3 | | K. Towns | 2/1/2017 | MIN | @ | CLE | 39 | 26 | 12 | 4 | 1 | 2 | 11 | 19 | 57.9 | 2 | 2 | 100.0 | 2 | 2 | 100.0 | 65.4 | 3 | 9 | 1 | 0 | -18 |
| 4 | | K. Towns | 2/14/2017 | MIN | vs | CLE | 39 | 26 | 8 | 4 | 0 | 1 | 11 | 19 | 57.9 | 1 | 4 | 25.0 | 3 | 3 | 100.0 | 64.0 | 2 | 6 | 2 | 4 | -2 |
| 5 | | K. Towns | 1/8/2018 | MIN | vs | CLE | 30 | 19 | 12 | 4 | 0 | 1 | 8 | 11 | 72.7 | 1 | 2 | 50.0 | 2 | 2 | 100.0 | 80.0 | 3 | 9 | 2 | 3 | +31 |
| 6 | | K. Towns | 2/7/2018 | MIN | @ | CLE | 37 | 30 | 10 | 1 | 1 | 2 | 10 | 12 | 83.3 | 6 | 6 | 100.0 | 4 | 4 | 100.0 | 109.0 | 1 | 9 | 3 | 2 | +1 |
| 7 | | K. Towns | 10/19/2018 | MIN | vs | CLE | 35 | 12 | 9 | 2 | 0 | 4 | 4 | 10 | 40.0 | 2 | 2 | 100.0 | 2 | 2 | 100.0 | 55.1 | 1 | 8 | 4 | 4 | +2 |
| 8 | | K. Towns | 11/26/2018 | MIN | @ | CLE | 38 | 21 | 10 | 1 | 1 | 0 | 9 | 19 | 47.4 | 2 | 7 | 28.6 | 1 | 2 | 50.0 | 52.8 | 2 | 8 | 2 | 0 | -7 |
| 9 | | K. Towns | 12/10/2021 | MIN | vs | CLE | 30 | 21 | 7 | 2 | 1 | 3 | 8 | 19 | 42.1 | 0 | 7 | 0.0 | 5 | 6 | 83.3 | 48.5 | 3 | 4 | 5 | 4 | -21 |
| 10 | | K. Towns | 2/28/2022 | MIN | @ | CLE | 34 | 17 | 4 | 3 | 1 | 1 | 7 | 13 | 53.8 | 1 | 4 | 25.0 | 2 | 2 | 100.0 | 61.2 | 1 | 3 | 1 | 4 | 0 |
| 11 | | K. Towns | 11/13/2022 | MIN | @ | CLE | 37 | 29 | 13 | 3 | 1 | 1 | 11 | 16 | 68.8 | 3 | 6 | 50.0 | 4 | 6 | 66.7 | 77.8 | 2 | 11 | 2 | 5 | +15 |
| 12 |  | K. Towns | 10/28/2024 |  NYK | vs | CLE | 32 | 13 | 10 | 3 | 1 | 0 | 4 | 8 | 50.0 | 1 | 2 | 50.0 | 4 | 4 | 100.0 | 66.6 | 1 | 9 | 3 | 6 | -1 |
| 13 | | K. Towns | 2/21/2025 | NYK | @ | CLE | 29 | 23 | 7 | 4 | 1 | 1 | 10 | 15 | 66.7 | 1 | 3 | 33.3 | 2 | 3 | 66.7 | 70.5 | 2 | 5 | 4 | 1 | -21 |
| 14 | | K. Towns | 4/2/2025 | NYK | @ | CLE | 34 | 25 | 13 | 1 | 0 | 0 | 9 | 16 | 56.3 | 1 | 3 | 33.3 | 6 | 7 | 85.7 | 65.5 | 3 | 10 | 7 | 5 | -9 |
| 15 | | K. Towns | 10/22/2025 | NYK | vs | CLE | 31 | 19 | 11 | 2 | 0 | 0 | 5 | 12 | 41.7 | 1 | 4 | 25.0 | 8 | 9 | 88.9 | 59.5 | 1 | 10 | 3 | 4 | +2 |
| Average | 33.9 | 21.9 | 9.5 | 2.7 | 0.6 | 1.1 | 8.6 | 14.6 | 58.9 | 1.5 | 3.5 | 41.5 | 3.3 | 3.8 | 86.0 | 67.4 | 2.1 | 7.5 | 2.9 | 3.2 | -3.1 | ||||||
| Total | 509 | 329 | 143 | 41 | 9 | 17 | 129 | 219 | 58.9 | 22 | 53 | 41.5 | 49 | 57 | 86.0 | 67.4 | 31 | 112 | 43 | 48 | -46 |
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