Wilt Chamberlain had the most games with 45+ points, with 176 games.

Interpreted as:

most 45+ point regular-season games by a player in NBA history

	NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TPG	MIN	REB	AST	STL	BLK	TOV	PF	+/-
1	Wilt Chamberlain W. Chamberlain	176	9,484		53.9	26.0				21.9	40.0	54.7				10.1	17.0	59.2	56.7					4,573					316
2	Michael Jordan M. Jordan	76	3,776	41.7	49.7	6.8	4.9	2.9	1.2	18.5	31.1	59.5	0.8	2.0	39.7	11.9	13.5	87.7	67.1	1.8	5.0	3.0	3,172	517	374	221	88	229	227	+136
3	Kobe Bryant K. Bryant	46	2,347	43.7	51.0	6.2	3.8	1.7	0.6	17.5	33.3	52.5	3.7	7.9	46.0	12.4	14.3	86.2	64.4	0.9	5.3	2.8	2,010	285	174	79	28	131	128	+417
4	James Harden J. Harden	41	2,098	40.3	51.2	7.2	7.4	2.2	0.6	15.0	28.3	52.9	6.3	13.7	45.9	15.0	16.7	89.6	71.8	1.3	6.0	5.1	1,651	297	305	91	25	210	123	+462
5	Elgin Baylor E. Baylor	41	2,048		50.0					18.5						12.9	16.2	79.4											153
6	Stephen Curry S. Curry	34	1,688	37.0	49.6	5.2	5.5	1.6	0.3	16.3	27.4	59.4	9.5	16.4	57.9	7.6	8.1	93.9	80.2	0.6	4.6	3.2	1,257	178	186	53	10	109	69	+365
7	Allen Iverson A. Iverson	32	1,556	45.5	48.6	4.4	6.0	2.5	0.2	16.7	32.4	51.6	2.3	5.6	42.1	12.8	15.4	83.5	62.1	1.0	3.4	4.1	1,456	140	192	81	5	130	83	+115
8	Rick Barry R. Barry	31	1,536	43.1	49.5	8.5	5.0	2.6		18.9	36.5	51.8				11.7	12.9	91.2	58.7	1.1	6.3	3.3	1,336	263	156	29		10	101
9	LeBron James L. James	27	1,349	41.9	50.0	8.0	6.9	1.7	0.9	17.2	28.5	60.3	4.9	8.8	55.9	10.7	13.0	82.3	73.1	1.4	6.5	3.2	1,131	215	185	45	23	86	51	+216
10	George Gervin G. Gervin	24	1,158	40.2	48.3	5.2	2.9	1.4	1.0	18.6	31.4	59.4	0.2	0.9	23.5	10.8	12.3	88.1	65.6				965	124	70	34	23		60
11	Dominique Wilkins D. Wilkins	23	1,118	41.9	48.6	7.7	3.1	2.0	0.6	17.6	30.8	57.1	1.2	2.3	52.8	12.3	14.1	86.8	65.7	3.6	4.1	3.3	963	178	71	46	14	77	46
12	Giannis Antetokounmpo G. Antetokounmpo	21	1,049	37.0	50.0	13.3	4.8	1.2	1.1	18.0	28.0	64.3	1.5	4.2	36.4	12.4	16.3	76.1	71.0	2.8	10.5	3.0	776	280	100	26	23	63	54	+182
13	Kevin Durant K. Durant	21	1,024	43.1	48.8	8.3	4.8	1.5	1.0	16.2	28.5	56.8	4.4	8.6	51.4	12.0	13.2	90.6	71.0	0.9	7.4	3.7	905	175	101	32	21	77	53	+79
14	Jerry West J. West	21	1,010		48.1					17.9	29.7	60.4				12.3	15.0	82.2	66.3
15	Damian Lillard D. Lillard	20	1,060	39.3	53.0	4.6	7.9	1.4	0.2	16.4	28.2	58.1	7.8	14.3	54.7	12.5	13.3	94.3	78.0	0.4	4.2	2.4	787	92	157	28	4	48	29	+213
16	Russell Westbrook R. Westbrook	20	966	39.4	48.3	9.7	8.1	2.0	0.3	16.5	32.4	50.9	3.6	9.0	39.7	11.8	13.8	85.5	62.8	1.6	8.1	4.8	788	193	162	39	5	95	54	+58
17	Kareem Abdul-Jabbar K. Abdul-Jabbar	20	988		49.4	15.3	4.2	0.3	1.8	19.8	31.6	62.5	0.0	0.0		9.9	13.5	73.6	65.8			6.0		305	83	1	7	6
18	Larry Bird L. Bird	19	920	43.1	48.4	10.9	6.2	1.9	0.9	18.8	31.1	60.6	1.2	3.1	39.0	9.5	10.4	91.9	67.9	2.5	8.5	3.9	818	208	118	36	17	75	46
19	Luka Dončić L. Dončić	18	898	39.5	49.9	10.4	9.1	1.9	0.6	16.8	28.0	59.9	6.2	11.8	52.8	10.1	12.9	78.1	74.0	0.8	9.6	3.8	710	187	163	34	11	69	47	+185
20	Bernard King B. King	18	878	41.2	48.8	8.2	3.7	1.6	0.3	18.3	29.8	61.6	0.1	0.4	28.6	12.0	15.2	78.8	66.9	3.1	5.1	3.6	742	148	66	28	6	64	54
21	Bob Pettit B. Pettit	18	878		48.8					18.2	32.9	55.2				12.4	15.0	83.0	61.8										63
22	Devin Booker D. Booker	17	878	39.0	51.6	5.4	5.9	1.2	0.5	18.5	30.4	61.0	4.4	9.4	47.2	10.2	11.5	88.7	72.9	0.9	4.5	3.2	663	92	100	21	8	54	46	+112
23	Adrian Dantley A. Dantley	17	823	42.6	48.4	6.9	4.2		0.1	16.5	23.9	69.0	0.0	0.1	0.0	15.5	18.0	85.9	76.1				724	118	71		1		55
24	Bob McAdoo B. McAdoo	17	814		47.9	16.6				19.3	29.3	65.9				9.3	11.6	80.2	69.6			5.0		283				5
25	Joel Embiid J. Embiid	16	809	35.8	50.6	13.4	4.7	1.6	2.3	17.7	27.3	64.8	1.1	3.2	35.3	14.1	15.8	88.9	73.8	3.3	10.1	3.1	573	214	75	25	37	49	44	+234