Shaquille O'Neal had the most points in a game in 1999-00, with 61 points against the Los Angeles Clippers on March 6, 2000.

Interpreted as:

most points by a player in a single regular-season game 2000,s

	NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	TS%	OREB	DREB	TOV	PF	+/-
1	Shaquille O'Neal S. O'Neal	61	3/6/2000	LAL	@	LAC	45	23	3	0	0	24	35	68.6	0	0		13	22	59.1	68.3	7	16	4	2	+16
2	Vince Carter V. Carter	51	2/27/2000	TOR	vs	PHX	43	9	1	3	0	17	32	53.1	4	8	50.0	13	13	100.0	67.6	5	4	5	5	+5
3	Allen Iverson A. Iverson	50	2/6/2000	PHI	vs	SAC	44	9	6	1	0	20	40	50.0	1	7	14.3	9	11	81.8	55.8	2	7	7	2	+14
4	Clifford Robinson C. Robinson	50	1/16/2000	PHX	vs	DEN	43	8	4	0	2	17	26	65.4	3	5	60.0	13	15	86.7	76.7	3	5	0	2	+25
5	Shaquille O'Neal S. O'Neal	49	4/5/2000	LAL	@	GSW	44	13	1	0	3	19	27	70.4	0	0		11	16	68.8	72.0	2	11	2	3	+8
6	Vince Carter V. Carter	47	1/14/2000	TOR	vs	MIL	43	5	4	2	2	20	32	62.5	3	3	100.0	4	4	100.0	69.6	3	2	3	5	+3
7	Tim Duncan T. Duncan	46	1/10/2000	SAS	vs	UTA	46	14	2	0	1	16	28	57.1	0	1	0.0	14	16	87.5	65.6	3	11	3	2	+6
8	Allen Iverson A. Iverson	46	11/10/1999	PHI	@	ORL	42	5	5	0	0	18	33	54.5	5	6	83.3	5	9	55.6	62.2	2	3	4	4	-8
9	Allen Iverson A. Iverson	45	1/3/2000	PHI	vs	MIL	43	4	4	1	0	16	38	42.1	2	5	40.0	11	18	61.1	49.0	2	2	1	5	+2
10	Nick Van Exel N. Van Exel	44	4/15/2000	DEN	@	LAC	49	3	8	0	0	16	32	50.0	5	11	45.5	7	9	77.8	61.2	0	3	3	5	+5
11	Elton Brand E. Brand	44	4/13/2000	CHI	vs	WAS	43	12	2	0	3	16	21	76.2	0	0		12	15	80.0	79.7	7	5	1	2	-11
12	Larry Hughes L. Hughes	44	4/9/2000	GSW	vs	DEN	44	6	7	3	1	16	29	55.2	1	2	50.0	11	15	73.3	61.8	0	6	3	2	+21
13	Allen Iverson A. Iverson	44	3/22/2000	PHI	vs	TOR	41	4	4	3	0	17	29	58.6	1	3	33.3	9	9	100.0	66.7	0	4	0	2	+21
14	Gary Payton G. Payton	43	4/16/2000	SEA	@	HOU	48	11	7	4	1	17	31	54.8	2	4	50.0	7	8	87.5	62.3	5	6	1	2	+9
15	Allen Iverson A. Iverson	43	3/28/2000	PHI	@	MIN	45	5	4	2	0	15	28	53.6	1	4	25.0	12	14	85.7	62.9	3	2	4	2	-3
16	Shaquille O'Neal S. O'Neal	43	3/19/2000	LAL	@	NYK	46	10	3	0	0	18	31	58.1	0	0		7	13	53.8	58.6	4	6	2	4	+6
17	Alonzo Mourning A. Mourning	43	2/23/2000	MIA	vs	NJN	33	16	0	0	5	13	14	92.9	0	0		17	24	70.8	87.5	7	9	2	2	+6
18	Stephon Marbury S. Marbury	42	1/27/2000	NJN	@	VAN	44	6	9	0	0	14	23	60.9	3	4	75.0	11	12	91.7	74.3	2	4	5	3	0
19	Grant Hill G. Hill	42	1/5/2000	DET	@	ATL	43	3	6	2	1	14	23	60.9	1	1	100.0	13	15	86.7	70.9	1	2	1	1	+20
20	Grant Hill G. Hill	42	1/3/2000	DET	@	ORL	44	7	8	2	1	17	30	56.7	3	5	60.0	5	7	71.4	63.5	3	4	3	2	+14
21	Allen Iverson A. Iverson	42	12/23/1999	PHI	@	NJN	46	3	0	1	0	11	26	42.3	3	7	42.9	17	20	85.0	60.3	0	3	2	3	-5
22	Tim Duncan T. Duncan	42	12/9/1999	SAS	vs	VAN	47	14	4	2	1	15	22	68.2	0	0		12	14	85.7	74.6	5	9	3	2	+9
23	Shaquille O'Neal S. O'Neal	41	4/14/2000	LAL	vs	SAC	45	16	2	0	0	16	29	55.2	0	0		9	15	60.0	57.6	7	9	8	5	+11
24	Larry Hughes L. Hughes	41	3/9/2000	GSW	vs	LAL	41	3	3	3	1	15	25	60.0	0	2	0.0	11	14	78.6	65.8	0	3	0	3	-3
25	Gary Payton G. Payton	41	2/15/2000	SEA	vs	WAS	30	3	5	2	0	14	21	66.7	7	12	58.3	6	7	85.7	85.1	0	3	2	3	+31