The San Francisco 49ers have a 10-7 record against the spread in the regular season and playoffs against the Cardinals and the NFC on the road since 2009.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/13/2009 | 1-0 | +190 | @ | -230 | W 20-16 | +6 | +10 (Y) | 46 | -10 (U) | 2 | 13 | 203 | 299 | 38.9 | |||
| 2 | | 49ers | 11/29/2010 | 1-0 | -130 | @ | +110 | W 27-6 | -2 | +19 (Y) | 41 | -8 (U) | 3 | 26 | 386 | 203 | 53.8 | |||
| 3 | | 49ers | 12/11/2011 | 0-1 | -180 | @ | +160 | L 19-21 | -3.5 | -5.5 (N) | 40 | 0 (P) | 1 | 12 | 233 | 325 | 17.6 | 50.0 | ||
| 4 | | 49ers | 10/29/2012 | 1-0 | -340 | @ | +280 | W 24-3 | -7 | +14 (Y) | 37.5 | -10.5 (U) | 3 | 15 | 317 | 265 | 50.0 | |||
| 5 | | 49ers | 12/29/2013 | 1-0 | +135 | @ | -155 | W 23-20 | +3 | +6 (Y) | 41 | +2 (O) | 2 | 19 | 375 | 482 | 23.1 | 0.0 | ||
| 6 | | 49ers | 9/21/2014 | 0-1 | -155 | @ | +135 | L 14-23 | -3 | -12 (N) | 41 | -4 (U) | 2 | 20 | 318 | 338 | 50.0 | 100.0 | ||
| 7 | | 49ers | 9/27/2015 | 0-1 | +250 | @ | -300 | L 7-47 | +6 | -34 (N) | 45 | +9 (O) | 1 | 10 | 156 | 446 | 33.3 | |||
| 8 | | 49ers | 11/13/2016 | 1-0 | +625 | @ | -900 | L 20-23 | +13.5 | +10.5 (Y) | 46.5 | -3.5 (U) | 2 | 15 | 281 | 443 | 41.2 | 100.0 | ||
| 9 | | 49ers | 10/1/2017 | 1-0 | +230 | @ | -270 | L 15-18 | +6.5 | +3.5 (Y) | 43.5 | -10.5 (U) | 0 | 20 | 305 | 368 | 26.3 | 100.0 | ||
| 10 | | 49ers | 10/28/2018 | 0-1 | -140 | @ | +130 | L 15-18 | -2.5 | -5.5 (N) | 40 | -7 (U) | 1 | 16 | 267 | 321 | 35.7 | |||
| 11 | | 49ers | 10/31/2019 | 0-1 | -521 | @ | +389 | W 28-25 | -10.5 | -7.5 (N) | 43.5 | +9.5 (O) | 4 | 21 | 411 | 357 | 64.7 | 100.0 | ||
| 12 | | 49ers | 12/26/2020 | 1-0 | +213 | @ | -266 | W 20-12 | +6 | +14 (Y) | 49 | -17 (U) | 3 | 22 | 398 | 350 | 22.2 | |||
| 13 | | 49ers | 10/10/2021 | 0-1 | +208 | @ | -257 | L 10-17 | +5.5 | -1.5 (N) | 48.5 | -21.5 (U) | 1 | 19 | 338 | 304 | 27.3 | 20.0 | ||
| 14 | | 49ers | 11/21/2022 | 1-0 | -442 | @ | +341 | W 38-10 | -9.5 | +18.5 (Y) | 43 | +5 (O) | 5 | 21 | 387 | 314 | 54.5 | |||
| 15 | | 49ers | 12/17/2023 | 1-0 | -771 | @ | +529 | W 45-29 | -12.5 | +3.5 (Y) | 48 | +26 (O) | 6 | 24 | 406 | 436 | 57.1 | |||
| 16 | | 49ers | 1/5/2025 | 0-1 | +188 | @ | -229 | L 24-47 | +4.5 | -18.5 (N) | 43 | +28 (O) | 3 | 26 | 436 | 393 | 38.5 | 50.0 | ||
| 17 | | 49ers | 11/16/2025 | 1-0 | -191 | @ | +158 | W 41-22 | -3.5 | +15.5 (Y) | 48.5 | +14.5 (O) | 5 | 24 | 281 | 488 | 33.3 | |||
| Average | 3.5 | 2.6 | 19.0 | 323.4 | 360.7 | 38.8 | 0.1 | |||||||||||||
| Total | 10-7 | 44 | 323 | 5,498 | 6,132 | 38.8 | 50.0 |
SF
ARIStatMuse has team, game-level data for spread records going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
789
Purdy
RUSH
166
McCaffrey
REC
174
Kittle
Team Rankings
PPG
32.7
2nd
OPP PPG
16.7
3rd
RUSH YDS/G
136.3
6th
PASS YDS/G
263.0
9th
Seahawks
Rams
DEN
WAS
ATL
LV
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
| NFC North | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
| NFC South | W | L | T | PCT |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
| NFC West | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 |
Eagles
Giants
Cowboys
Vikings
Lions
Bears
Packers
Panthers
Saints
Buccaneers| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 0 | 0 | 1.000 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
2 | 2 | 0 | .500 | |
| AFC South | W | L | T | PCT |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
0 | 3 | 0 | .000 | |
| AFC West | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
0 | 3 | 0 | .000 |
Bills
Jets
Patriots
Dolphins
Browns
Ravens
Bengals
Steelers
Jaguars
Colts
Titans
Texans
Chiefs
Chargers