49ers ats since 2017 in regular season vs afc

The San Francisco 49ers are 21-20 against the spread against the AFC since 2017.

		TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1		49ers	10/8/2017	0-1	SF	+105	@	IND	-125	L 23-26	+1.5	-1.5 (N)	44	+5 (O)	2	23	402	447	28.6	100.0
2		49ers	12/10/2017	1-0	SF	+108	@	HOU	-118	W 26-16	-1.5	+8.5 (Y)	45.5	-3.5 (U)	2	20	416	311	18.2
3		49ers	12/17/2017	0-1	SF	-135	vs	TEN	+125	W 25-23	-2.5	-0.5 (N)	44.5	+3.5 (O)	1	23	414	328	50.0
4		49ers	12/24/2017	1-0	SF	+190	vs	JAX	-210	W 44-33	+4	+15 (Y)	43	+34 (O)	6	26	369	472	66.7
5		49ers	9/23/2018	0-1	SF	+225	@	KC	-245	L 27-38	+5.5	-5.5 (N)	53.5	+11.5 (O)	3	26	406	384	22.2	100.0
6		49ers	9/30/2018	1-0	SF	+370	@	LAC	-415	L 27-29	+9.5	+7.5 (Y)	46.5	+9.5 (O)	3	22	364	368	41.7
7		49ers	11/1/2018	1-0	SF	+115	vs	OAK	-125	W 34-3	+2	+33 (Y)	44	-7 (U)	4	18	405	242	41.7
8		49ers	12/9/2018	1-0	SF	+142	vs	DEN	-152	W 20-14	+3	+9 (Y)	45.5	-11.5 (U)	2	24	389	274	30.8	0.0
9		49ers	9/15/2019	1-0	SF	-110	@	CIN	-110	W 41-17	+1	+25 (Y)	46.5	+11.5 (O)	5	27	571	316	55.6
10		49ers	9/22/2019	0-1	SF	-301	vs	PIT	+242	W 24-20	-6.5	-2.5 (N)	44	0 (P)	3	26	436	239	54.5
11		49ers	10/7/2019	1-0	SF	-227	vs	CLE	+187	W 31-3	-4.5	+23.5 (Y)	48	-14 (U)	4	22	446	180	37.5	100.0
12		49ers	12/1/2019	1-0	SF	+204	@	BAL	-250	L 17-20	+5.5	+2.5 (Y)	45	-8 (U)	2	15	331	283	33.3	50.0
13		49ers	9/20/2020	1-0	SF	-325	@	NYJ	+265	W 31-13	-7	+11 (Y)	41.5	+2.5 (O)	4	17	359	277	53.8
14		49ers	10/11/2020	0-1	SF	-390	vs	MIA	+314	L 17-43	-8.5	-34.5 (N)	50.5	+9.5 (O)	2	19	259	436	20.0	0.0
15		49ers	10/25/2020	1-0	SF	+131	@	NE	-155	W 33-6	+3	+30 (Y)	44.5	-5.5 (U)	4	26	467	241	55.6
16		49ers	12/7/2020	0-1	SF	-124	vs	BUF	+105	L 24-34	-1.5	-11.5 (N)	48	+10 (O)	3	24	402	449	54.5	0.0
17		49ers	10/24/2021	0-1	SF	-176	vs	IND	+147	L 18-30	-3.5	-15.5 (N)	41.5	+6.5 (O)	2	13	280	295	9.1
18		49ers	11/21/2021	1-0	SF	-290	@	JAX	+233	W 30-10	-6.5	+13.5 (Y)	45.5	-5.5 (U)	3	25	333	200	50.0	100.0
19		49ers	12/12/2021	1-0	SF	-128	@	CIN	+106	W 26-23	-1.5	+1.5 (Y)	49	0 (P)	3	21	355	397	33.3
20		49ers	12/23/2021	0-1	SF	-175	@	TEN	+147	L 17-20	-3.5	-6.5 (N)	45.5	-8.5 (U)	2	22	389	278	37.5	50.0
21		49ers	1/2/2022	1-0	SF	-740	vs	HOU	+507	W 23-7	-13.5	+2.5 (Y)	44.5	-14.5 (U)	2	19	416	222	38.5	0.0
22		49ers	9/25/2022	0-1	SF	-123	@	DEN	+102	L 10-11	-1.5	-2.5 (N)	45	-24 (U)	1	13	267	261	10.0
23		49ers	10/23/2022	0-1	SF	-103	vs	KC	-118	L 23-44	+1	-20 (N)	49	+18 (O)	2	25	444	529	57.1
24		49ers	11/13/2022	0-1	SF	-361	vs	LAC	+284	W 22-16	-8	-2 (N)	45.5	-7.5 (U)	2	22	387	238	52.9	100.0
25		49ers	12/4/2022	1-0	SF	-233	vs	MIA	+191	W 33-17	-5	+11 (Y)	46	+4 (O)	3	24	351	308	42.1	50.0
		Average		1.2											2.8	21.4	378.9	323.1	42.7	2.4
		Total		21-20											114	877	15,533	13,247	42.7	53.1

StatMuse has team, game-level data for spread records going back to the 1979 season.

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OPP PPG

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2025 Division Standings

TEAM	W	L	T	PCT
Seahawks	14	3	0	.824
Rams	12	5	0	.706
49ers	12	5	0	.706
Cardinals	3	14	0	.176

1 - 1

6

Final

41

SEA

1 - 0

Sat 17 Jan 2026

NFL 2025 Leaders

Pass Yards Leaders

4,707

Stafford

Matthew Stafford

4,564

Goff

Jared Goff

4,552

Prescott

Dak Prescott

Rush Yards Leaders

1,621

Cook

James Cook III

1,595

Henry

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1,585

Taylor

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Rec Yards Leaders

1,793

Smith-Njigba

Jaxon Smith-Njigba

1,715

Nacua

Puka Nacua

1,429

Pickens

George Pickens

Pass TD Leaders

46

Stafford

Matthew Stafford

34

Goff

Jared Goff

31

Maye

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Rush TD Leaders

18

Taylor

Jonathan Taylor

16

Henry

Derrick Henry

14

Allen

Josh Allen

14

Adams

Davante Adams

11

McBride

Trey McBride

11

St. Brown

Amon-Ra St. Brown

QB Rating Leaders

113.5

Maye

Drake Maye

109.2

Stafford

Matthew Stafford

105.5

Goff

Jared Goff

23.0

Garrett

Myles Garrett

16.5

Burns

Brian Burns

15.0

Hunter

Danielle Hunter

NFL 2025 Rankings

30.5

28.8

28.4

28.3

28.3

27.9

Opp PPG Rankings

17.2

17.4

18.3

18.8

19.1

19.3

Total Yards Rankings

394.6

391.9

379.4

376.3

373.2

369.5

Rush Yards Rankings

159.6

156.6

144.5

134.7

129.1

128.9

Pass Yards Rankings

278.5

276.9

268.6

262.3

256.1

254.0

68.0

57.0

53.0

49.0

49.0

48.0

NFL Fantasy 2025

Fantasy RB Rankings

316.3

Taylor

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314.6

McCaffrey

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291.8

Robinson

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Fantasy WR Rankings

246

Nacua

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240.9

Smith-Njigba

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207

St. Brown

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Fantasy TE Rankings

189.9

McBride

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122.8

Pitts

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Fantasy K Rankings

202

Myers

Jason Myers

194

Fairbairn

Ka'imi Fairbairn

187.6

Aubrey

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NFL 2025 Betting

Best Record ATS

15-5

12-6

14-7

12-6-1

12-7

11-7

Worst Record ATS

5-12

5-12-1

6-11

6-11

6-11

7-10

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
NFC South	W	L	T	PCT
Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176