49ers ats since 2017 in regular season vs afc

The San Francisco 49ers have a 20-20 record against the spread against the AFC since 2017.

		TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1		49ers	10/8/2017	0-1	SF	+105	@	IND	-125	L 23-26	+1.5	-1.5 (N)	44	+5 (O)	2	23	402	447	28.6	100.0
2		49ers	12/10/2017	1-0	SF	+108	@	HOU	-118	W 26-16	-1.5	+8.5 (Y)	45.5	-3.5 (U)	2	20	416	311	18.2
3		49ers	12/17/2017	0-1	SF	-135	vs	TEN	+125	W 25-23	-2.5	-0.5 (N)	44.5	+3.5 (O)	1	23	414	328	50.0
4		49ers	12/24/2017	1-0	SF	+190	vs	JAX	-210	W 44-33	+4	+15 (Y)	43	+34 (O)	6	26	369	472	66.7
5		49ers	9/23/2018	0-1	SF	+225	@	KC	-245	L 27-38	+5.5	-5.5 (N)	53.5	+11.5 (O)	3	26	406	384	22.2	100.0
6		49ers	9/30/2018	1-0	SF	+370	@	LAC	-415	L 27-29	+9.5	+7.5 (Y)	46.5	+9.5 (O)	3	22	364	368	41.7
7		49ers	11/1/2018	1-0	SF	+115	vs	OAK	-125	W 34-3	+2	+33 (Y)	44	-7 (U)	4	18	405	242	41.7
8		49ers	12/9/2018	1-0	SF	+142	vs	DEN	-152	W 20-14	+3	+9 (Y)	45.5	-11.5 (U)	2	24	389	274	30.8	0.0
9		49ers	9/15/2019	1-0	SF	-110	@	CIN	-110	W 41-17	+1	+25 (Y)	46.5	+11.5 (O)	5	27	571	316	55.6
10		49ers	9/22/2019	0-1	SF	-301	vs	PIT	+242	W 24-20	-6.5	-2.5 (N)	44	0 (P)	3	26	436	239	54.5
11		49ers	10/7/2019	1-0	SF	-227	vs	CLE	+187	W 31-3	-4.5	+23.5 (Y)	48	-14 (U)	4	22	446	180	37.5	100.0
12		49ers	12/1/2019	1-0	SF	+204	@	BAL	-250	L 17-20	+5.5	+2.5 (Y)	45	-8 (U)	2	15	331	283	33.3	50.0
13		49ers	9/20/2020	1-0	SF	-325	@	NYJ	+265	W 31-13	-7	+11 (Y)	41.5	+2.5 (O)	4	17	359	277	53.8
14		49ers	10/11/2020	0-1	SF	-390	vs	MIA	+314	L 17-43	-8.5	-34.5 (N)	50.5	+9.5 (O)	2	19	259	436	20.0	0.0
15		49ers	10/25/2020	1-0	SF	+131	@	NE	-155	W 33-6	+3	+30 (Y)	44.5	-5.5 (U)	4	26	467	241	55.6
16		49ers	12/7/2020	0-1	SF	-124	vs	BUF	+105	L 24-34	-1.5	-11.5 (N)	48	+10 (O)	3	24	402	449	54.5	0.0
17		49ers	10/24/2021	0-1	SF	-176	vs	IND	+147	L 18-30	-3.5	-15.5 (N)	41.5	+6.5 (O)	2	13	280	295	9.1
18		49ers	11/21/2021	1-0	SF	-290	@	JAX	+233	W 30-10	-6.5	+13.5 (Y)	45.5	-5.5 (U)	3	25	333	200	50.0	100.0
19		49ers	12/12/2021	1-0	SF	-128	@	CIN	+106	W 26-23	-1.5	+1.5 (Y)	49	0 (P)	3	21	355	397	33.3
20		49ers	12/23/2021	0-1	SF	-175	@	TEN	+147	L 17-20	-3.5	-6.5 (N)	45.5	-8.5 (U)	2	22	389	278	37.5	50.0
21		49ers	1/2/2022	1-0	SF	-740	vs	HOU	+507	W 23-7	-13.5	+2.5 (Y)	44.5	-14.5 (U)	2	19	416	222	38.5	0.0
22		49ers	9/25/2022	0-1	SF	-123	@	DEN	+102	L 10-11	-1.5	-2.5 (N)	45	-24 (U)	1	13	267	261	10.0
23		49ers	10/23/2022	0-1	SF	-103	vs	KC	-118	L 23-44	+1	-20 (N)	49	+18 (O)	2	25	444	529	57.1
24		49ers	11/13/2022	0-1	SF	-361	vs	LAC	+284	W 22-16	-8	-2 (N)	45.5	-7.5 (U)	2	22	387	238	52.9	100.0
25		49ers	12/4/2022	1-0	SF	-233	vs	MIA	+191	W 33-17	-5	+11 (Y)	46	+4 (O)	3	24	351	308	42.1	50.0
		Average		1.3											2.7	21.2	377.3	323.4	42.3	2.5
		Total		20-20											108	849	15,093	12,935	42.3	51.6

StatMuse has team, game-level data for spread records going back to the 1979 season.

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More 49ers Stats

PASS

2,151

Jones

Mac Jones

RUSH

922

McCaffrey

Christian McCaffrey

REC

820

McCaffrey

Christian McCaffrey

PPG

24.6

11th

OPP PPG

20.9

11th

RUSH YDS/G

101.4

25th

PASS YDS/G

256.6

6th

2025 Division Standings

TEAM	W	L	T	PCT
Seahawks	12	3	0	.800
Rams	11	4	0	.733
49ers	10	4	0	.714
Cardinals	3	11	0	.214

DATE	MATCHUP			TIME (ET)
Mon 12/22	SF	@	IND	8:15 PM
Sun 12/28	CHI	@	SF	8:20 PM
Sun 1/4	SEA	@	SF	1:00 PM

TEN

2 - 12

24

Final

37

10 - 4

Sun 14 Dec 2025

NFL 2025 Leaders

Pass Yards Leaders

4,179

Stafford

Matthew Stafford

3,931

Prescott

Dak Prescott

3,703

Darnold

Sam Darnold

Rush Yards Leaders

1,443

Taylor

Jonathan Taylor

1,415

Cook

James Cook III

1,186

Achane

De'Von Achane

Rec Yards Leaders

1,637

Smith-Njigba

Jaxon Smith-Njigba

1,592

Nacua

Puka Nacua

1,212

Pickens

George Pickens

Pass TD Leaders

40

Stafford

Matthew Stafford

29

Goff

Jared Goff

26

Prescott

Dak Prescott

Rush TD Leaders

16

Taylor

Jonathan Taylor

13

Gibbs

Jahmyr Gibbs

13

Jacobs

Josh Jacobs

14

Adams

Davante Adams

11

St. Brown

Amon-Ra St. Brown

10

Smith-Njigba

Jaxon Smith-Njigba

QB Rating Leaders

112.1

Stafford

Matthew Stafford

110.4

Goff

Jared Goff

109.1

Maye

Drake Maye

21.5

Garrett

Myles Garrett

13.0

Burns

Brian Burns

12.5

Parsons

Micah Parsons

NFL 2025 Rankings

30.6

30.5

29.5

29.4

29.1

28.0

Opp PPG Rankings

16.3

18.6

18.6

19.1

19.4

19.7

Total Yards Rankings

396.9

396.7

381.2

379.9

369.4

364.2

Rush Yards Rankings

158.5

152.2

146.2

137.1

131.1

128.9

Pass Yards Rankings

287.9

278.6

262.5

262.0

257.8

256.6

58.0

48.0

47.0

42.0

41.0

40.0

NFL Fantasy 2025

Fantasy RB Rankings

284.1

Taylor

Jonathan Taylor

258.2

McCaffrey

Christian McCaffrey

255.4

Gibbs

Jahmyr Gibbs

Fantasy WR Rankings

225.3

Smith-Njigba

Jaxon Smith-Njigba

219.3

Nacua

Puka Nacua

180.9

St. Brown

Amon-Ra St. Brown

Fantasy TE Rankings

167.1

McBride

Trey McBride

111.8

Kelce

Travis Kelce

109.1

Goedert

Dallas Goedert

Fantasy K Rankings

184

Myers

Jason Myers

160.6

Aubrey

Brandon Aubrey

153

Dicker

Cameron Dicker

NFL 2025 Betting

Best Record ATS

11-4

9-4-1

10-5

9-5

9-5

9-5

Worst Record ATS

5-9

5-9

5-9

5-9

5-9

5-9

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots	11	3	0	.786
Bills	10	4	0	.714
Dolphins - e	6	8	0	.429
Jets - e	3	11	0	.214
AFC North	W	L	T	PCT
Steelers	8	6	0	.571
Ravens	7	7	0	.500
Bengals - e	4	10	0	.286
Browns - e	3	11	0	.214
AFC South	W	L	T	PCT
Jaguars	10	4	0	.714
Texans	9	5	0	.643
Colts	8	6	0	.571
Titans - e	2	12	0	.143
AFC West	W	L	T	PCT
Broncos - x	12	2	0	.857
Chargers	10	4	0	.714
Chiefs - e	6	8	0	.429
Raiders - e	2	12	0	.143

NFC East	W	L	T	PCT
Eagles	9	5	0	.643
Cowboys	6	7	1	.464
Commanders - e	4	10	0	.286
Giants - e	2	12	0	.143
NFC North	W	L	T	PCT
Bears	10	4	0	.714
Packers	9	4	1	.679
Lions	8	6	0	.571
Vikings - e	6	8	0	.429
NFC South	W	L	T	PCT
Buccaneers	7	7	0	.500
Panthers	7	7	0	.500
Falcons - e	5	9	0	.357
Saints - e	4	10	0	.286
NFC West	W	L	T	PCT
Seahawks	12	3	0	.800
Rams - x	11	4	0	.733
49ers	10	4	0	.714
Cardinals - e	3	11	0	.214

NFL 2025 Scores & Schedule

Scores

DATE	MATCHUP			SCORE
Sat 9/13	NE	@	MIA	33-27
Sat 9/13	CAR	@	ARI	22-27
Sat 9/13	DEN	@	IND	28-29
Sat 9/13	PHI	@	KC	20-17
Sat 9/13	ATL	@	MIN	22-6

Schedule

DATE	MATCHUP			TIME (ET)
Sat 12/20	PHI	@	WAS	5:00 PM
Sat 12/20	GB	@	CHI	8:20 PM
Sun 12/21	BUF	@	CLE	1:00 PM
Sun 12/21	LAC	@	DAL	1:00 PM
Sun 12/21	NYJ	@	NO	1:00 PM