The San Francisco 49ers are 4-6 against the spread in the regular season against the AFC West since 2017.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/23/2018 | 0-1 | +225 | @ | -245 | L 27-38 | +5.5 | -5.5 (N) | 53.5 | +11.5 (O) | 3 | 26 | 406 | 384 | 22.2 | 100.0 | ||
| 2 | | 49ers | 9/30/2018 | 1-0 | +370 | @ | -415 | L 27-29 | +9.5 | +7.5 (Y) | 46.5 | +9.5 (O) | 3 | 22 | 364 | 368 | 41.7 | |||
| 3 | | 49ers | 11/1/2018 | 1-0 | +115 | vs | -125 | W 34-3 | +2 | +33 (Y) | 44 | -7 (U) | 4 | 18 | 405 | 242 | 41.7 | |||
| 4 | | 49ers | 12/9/2018 | 1-0 | +142 | vs | -152 | W 20-14 | +3 | +9 (Y) | 45.5 | -11.5 (U) | 2 | 24 | 389 | 274 | 30.8 | 0.0 | ||
| 5 | | 49ers | 9/25/2022 | 0-1 | -123 | @ | +102 | L 10-11 | -1.5 | -2.5 (N) | 45 | -24 (U) | 1 | 13 | 267 | 261 | 10.0 | |||
| 6 | | 49ers | 10/23/2022 | 0-1 | -103 | vs | -118 | L 23-44 | +1 | -20 (N) | 49 | +18 (O) | 2 | 25 | 444 | 529 | 57.1 | |||
| 7 | | 49ers | 11/13/2022 | 0-1 | -361 | vs | +284 | W 22-16 | -8 | -2 (N) | 45.5 | -7.5 (U) | 2 | 22 | 387 | 238 | 52.9 | 100.0 | ||
| 8 | | 49ers | 1/1/2023 | 0-1 | -472 | @ | +359 | W 37-34 | -10 | -7 (N) | 41 | +30 (O) | 4 | 27 | 454 | 500 | 50.0 | |||
| 9 | | 49ers | 10/20/2024 | 0-1 | -143 | vs | +121 | L 18-28 | -2.5 | -12.5 (N) | 48 | -2 (U) | 2 | 19 | 310 | 329 | 18.2 | 100.0 | ||
| 10 | | 49ers | 10/4/2026 | 1-0 | -175 | vs | +149 | W 24-14 | -3 | +7 (Y) | 48.5 | -10.5 (U) | 3 | 20 | 358 | 296 | 46.2 | 50.0 | ||
| Average | 4.0 | 2.6 | 21.6 | 378.4 | 342.1 | 38.7 | 0.1 | |||||||||||||
| Total | 4-6 | 26 | 216 | 3,784 | 3,421 | 38.7 | 71.4 |
SF
KC
LAC
OAK
DENStatMuse has team, game-level data for spread records going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
1,007
Purdy
RUSH
218
McCaffrey
REC
244
Kittle
Team Rankings
PPG
30.5
2nd
OPP PPG
16.0
3rd
RUSH YDS/G
137.3
6th
PASS YDS/G
251.8
14th
Seahawks
Rams
Cardinals
WAS
ATL
DAL
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 0 | .250 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 |
Giants
Eagles
Vikings
Bears
Lions
Packers
Panthers
Buccaneers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 |
Bills
Patriots
Jets
Dolphins
Browns
Ravens
Steelers
Bengals
Jaguars
Colts
Texans
Titans