The San Francisco 49ers are 18-22 against the spread against the AFC in the regular-season and playoffs since 2017.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/8/2017 | 0-1 |  SF | +105 | @ |  IND | -125 | L 23-26 | +1.5 | -1.5 (N) | 44 | +5 (O) | 2 | 23 | 402 | 447 | 28.6 | 100.0 |
| 2 | | 49ers | 12/10/2017 | 1-0 | SF | +108 | @ |  HOU | -118 | W 26-16 | -1.5 | +8.5 (Y) | 45.5 | -3.5 (U) | 2 | 20 | 416 | 311 | 18.2 | |
| 3 | | 49ers | 12/17/2017 | 0-1 | SF | -135 | vs |  TEN | +125 | W 25-23 | -2.5 | -0.5 (N) | 44.5 | +3.5 (O) | 1 | 23 | 414 | 328 | 50.0 | |
| 4 | | 49ers | 12/24/2017 | 1-0 | SF | +190 | vs |  JAX | -210 | W 44-33 | +4 | +15 (Y) | 43 | +34 (O) | 6 | 26 | 369 | 472 | 66.7 | |
| 5 | | 49ers | 9/23/2018 | 0-1 | SF | +225 | @ |  KC | -245 | L 27-38 | +5.5 | -5.5 (N) | 53.5 | +11.5 (O) | 3 | 26 | 406 | 384 | 22.2 | 100.0 |
| 6 | | 49ers | 9/30/2018 | 1-0 | SF | +370 | @ |  LAC | -415 | L 27-29 | +9.5 | +7.5 (Y) | 46.5 | +9.5 (O) | 3 | 22 | 364 | 368 | 41.7 | |
| 7 | | 49ers | 11/1/2018 | 1-0 | SF | +115 | vs |  OAK | -125 | W 34-3 | +2 | +33 (Y) | 44 | -7 (U) | 4 | 18 | 405 | 242 | 41.7 | |
| 8 | | 49ers | 12/9/2018 | 1-0 | SF | +142 | vs |  DEN | -152 | W 20-14 | +3 | +9 (Y) | 45.5 | -11.5 (U) | 2 | 24 | 389 | 274 | 30.8 | 0.0 |
| 9 | | 49ers | 9/15/2019 | 1-0 | SF | -110 | @ |  CIN | -110 | W 41-17 | +1 | +25 (Y) | 46.5 | +11.5 (O) | 5 | 27 | 571 | 316 | 55.6 | |
| 10 | | 49ers | 9/22/2019 | 0-1 | SF | -301 | vs |  PIT | +242 | W 24-20 | -6.5 | -2.5 (N) | 44 | 0 (P) | 3 | 26 | 436 | 239 | 54.5 | |
| 11 | | 49ers | 10/7/2019 | 1-0 | SF | -227 | vs |  CLE | +187 | W 31-3 | -4.5 | +23.5 (Y) | 48 | -14 (U) | 4 | 22 | 446 | 180 | 37.5 | 100.0 |
| 12 | | 49ers | 12/1/2019 | 1-0 | SF | +204 | @ |  BAL | -250 | L 17-20 | +5.5 | +2.5 (Y) | 45 | -8 (U) | 2 | 15 | 331 | 283 | 33.3 | 50.0 |
| 13 | | 49ers | 2/2/2020 | 0-1 | SF | +104 | @ | KC | -125 | L 20-31 | +1.5 | -9.5 (N) | 53 | -2 (U) | 2 | 21 | 351 | 397 | 37.5 | 0.0 |
| 14 | | 49ers | 9/20/2020 | 1-0 | SF | -325 | @ |  NYJ | +265 | W 31-13 | -7 | +11 (Y) | 41.5 | +2.5 (O) | 4 | 17 | 359 | 277 | 53.8 | |
| 15 | | 49ers | 10/11/2020 | 0-1 | SF | -390 | vs |  MIA | +314 | L 17-43 | -8.5 | -34.5 (N) | 50.5 | +9.5 (O) | 2 | 19 | 259 | 436 | 20.0 | 0.0 |
| 16 | | 49ers | 10/25/2020 | 1-0 | SF | +131 | @ |  NE | -155 | W 33-6 | +3 | +30 (Y) | 44.5 | -5.5 (U) | 4 | 26 | 467 | 241 | 55.6 | |
| 17 | | 49ers | 12/7/2020 | 0-1 | SF | -124 | vs |  BUF | +105 | L 24-34 | -1.5 | -11.5 (N) | 48 | +10 (O) | 3 | 24 | 402 | 449 | 54.5 | 0.0 |
| 18 | | 49ers | 10/24/2021 | 0-1 | SF | -176 | vs | IND | +147 | L 18-30 | -3.5 | -15.5 (N) | 41.5 | +6.5 (O) | 2 | 13 | 280 | 295 | 9.1 | |
| 19 | | 49ers | 11/21/2021 | 1-0 | SF | -290 | @ | JAX | +233 | W 30-10 | -6.5 | +13.5 (Y) | 45.5 | -5.5 (U) | 3 | 25 | 333 | 200 | 50.0 | 100.0 |
| 20 | | 49ers | 12/12/2021 | 1-0 | SF | -128 | @ | CIN | +106 | W 26-23 | -1.5 | +1.5 (Y) | 49 | 0 (P) | 3 | 21 | 355 | 397 | 33.3 | |
| 21 | | 49ers | 12/23/2021 | 0-1 | SF | -175 | @ | TEN | +147 | L 17-20 | -3.5 | -6.5 (N) | 45.5 | -8.5 (U) | 2 | 22 | 389 | 278 | 37.5 | 50.0 |
| 22 | | 49ers | 1/2/2022 | 1-0 | SF | -740 | vs | HOU | +507 | W 23-7 | -13.5 | +2.5 (Y) | 44.5 | -14.5 (U) | 2 | 19 | 416 | 222 | 38.5 | 0.0 |
| 23 | | 49ers | 9/25/2022 | 0-1 | SF | -123 | @ | DEN | +102 | L 10-11 | -1.5 | -2.5 (N) | 45 | -24 (U) | 1 | 13 | 267 | 261 | 10.0 | |
| 24 | | 49ers | 10/23/2022 | 0-1 | SF | -103 | vs | KC | -118 | L 23-44 | +1 | -20 (N) | 49 | +18 (O) | 2 | 25 | 444 | 529 | 57.1 | |
| 25 | | 49ers | 11/13/2022 | 0-1 | SF | -361 | vs | LAC | +284 | W 22-16 | -8 | -2 (N) | 45.5 | -7.5 (U) | 2 | 22 | 387 | 238 | 52.9 | 100.0 |
| Average | 1.1 | 2.6 | 21.2 | 378.6 | 330.7 | 40.4 | 2.3 | |||||||||||||
| Total | 18-22 | 105 | 846 | 15,144 | 13,228 | 40.4 | 50.0 | |||||||||||||
StatMuse has team, game-level data for spread records going back to the 1979 season.
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20.0
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OPP PPG
20.5
8th
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89.4
30th
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