49ers record against the spread in 2021

The San Francisco 49ers were 13-7 against the spread in 2021.

		TEAM	DATE	ATS	SEASON	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1		49ers	9/12/2021	1-0	2021	SF	-371	@	DET	+285	W 41-33	-7.5	+0.5 (Y)	45	+29 (O)	5	21	442	430	33.3
2		49ers	9/19/2021	1-0	2021	SF	-150	@	PHI	+127	W 17-11	-3	+3 (Y)	49	-21 (U)	2	23	306	328	42.9	100.0
3		49ers	9/26/2021	0-1	2021	SF	-174	vs	GB	+148	L 28-30	-3	-5 (N)	50.5	+7.5 (O)	4	26	298	353	63.6
4		49ers	10/3/2021	0-1	2021	SF	-137	vs	SEA	+115	L 21-28	-2.5	-9.5 (N)	52	-3 (U)	3	23	457	234	14.3	75.0
5		49ers	10/10/2021	0-1	2021	SF	+208	@	ARI	-257	L 10-17	+5.5	-1.5 (N)	48.5	-21.5 (U)	1	19	338	304	27.3	20.0
6		49ers	10/24/2021	0-1	2021	SF	-176	vs	IND	+147	L 18-30	-3.5	-15.5 (N)	41.5	+6.5 (O)	2	13	280	295	9.1
7		49ers	10/31/2021	1-0	2021	SF	-210	@	CHI	+172	W 33-22	-4.5	+6.5 (Y)	40	+15 (O)	3	21	467	324	40.0	100.0
8		49ers	11/7/2021	0-1	2021	SF	-247	vs	ARI	+199	L 17-31	-5.5	-19.5 (N)	44.5	+3.5 (O)	2	22	337	437	40.0
9		49ers	11/15/2021	1-0	2021	SF	+154	vs	LAR	-184	W 31-10	+3.5	+24.5 (Y)	50	-9 (U)	4	20	335	278	57.1	50.0
10		49ers	11/21/2021	1-0	2021	SF	-290	@	JAX	+233	W 30-10	-6.5	+13.5 (Y)	45.5	-5.5 (U)	3	25	333	200	50.0	100.0
11		49ers	11/28/2021	1-0	2021	SF	-200	vs	MIN	+168	W 34-26	-4	+4 (Y)	49	+11 (O)	4	23	423	323	41.7
12		49ers	12/5/2021	0-1	2021	SF	-143	@	SEA	+122	L 23-30	-2.5	-9.5 (N)	44.5	+8.5 (O)	3	17	365	327	30.0	50.0
13		49ers	12/12/2021	1-0	2021	SF	-128	@	CIN	+106	W 26-23	-1.5	+1.5 (Y)	49	0 (P)	3	21	355	397	33.3
14		49ers	12/19/2021	1-0	2021	SF	-408	vs	ATL	+311	W 31-13	-9	+9 (Y)	47.5	-3.5 (U)	4	23	397	275	54.5
15		49ers	12/23/2021	0-1	2021	SF	-175	@	TEN	+147	L 17-20	-3.5	-6.5 (N)	45.5	-8.5 (U)	2	22	389	278	37.5	50.0
16		49ers	1/2/2022	1-0	2021	SF	-740	vs	HOU	+507	W 23-7	-13.5	+2.5 (Y)	44.5	-14.5 (U)	2	19	416	222	38.5	0.0
17		49ers	1/9/2022	1-0	2021	SF	+151	@	LAR	-178	W 27-24	+3.5	+6.5 (Y)	46.5	+4.5 (O)	3	23	449	265	64.3
18		49ers	1/16/2022	1-0	2021	SF	+153	@	DAL	-181	W 23-17	+3.5	+9.5 (Y)	51	-11 (U)	2	21	341	307	46.2
19		49ers	1/22/2022	1-0	2021	SF	+208	@	GB	-254	W 13-10	+5.5	+8.5 (Y)	47	-24 (U)	1	12	212	263	36.4	0.0
20		49ers	1/30/2022	1-0	2021	SF	+155	@	LAR	-183	L 17-20	+3.5	+0.5 (Y)	45.5	-8.5 (U)	2	16	282	396	33.3
		Average		3.3												2.8	20.5	361.1	311.8	40.1	4.8
		Total		13-7												55	410	7,222	6,236	40.1	47.6

StatMuse has team, game-level data for spread records going back to the 1979 season.

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More 49ers Stats

PASS

2,151

Jones

Mac Jones

RUSH

1,179

McCaffrey

Christian McCaffrey

REC

890

McCaffrey

Christian McCaffrey

PPG

27.1

8th

OPP PPG

22.4

13th

RUSH YDS/G

110.3

22nd

PASS YDS/G

261.9

5th

2025 Division Standings

TEAM	W	L	T	PCT
Seahawks	13	3	0	.813
49ers	12	4	0	.750
Rams	11	4	0	.733
Cardinals	3	13	0	.188

DATE	MATCHUP			TIME (ET)
Sat 1/3	SEA	@	SF	8:00 PM

11 - 5

38

Final

42

12 - 4

Sun 28 Dec 2025

NFL 2025 Leaders

Pass Yards Leaders

4,482

Prescott

Dak Prescott

4,233

Goff

Jared Goff

4,203

Maye

Drake Maye

Rush Yards Leaders

1,606

Cook

James Cook III

1,559

Taylor

Jonathan Taylor

1,469

Henry

Derrick Henry

Rec Yards Leaders

1,709

Smith-Njigba

Jaxon Smith-Njigba

1,592

Nacua

Puka Nacua

1,420

Pickens

George Pickens

Pass TD Leaders

40

Stafford

Matthew Stafford

33

Goff

Jared Goff

30

Maye

Drake Maye

Rush TD Leaders

18

Taylor

Jonathan Taylor

16

Henry

Derrick Henry

14

Allen

Josh Allen

14

Adams

Davante Adams

11

McBride

Trey McBride

11

St. Brown

Amon-Ra St. Brown

QB Rating Leaders

112.9

Maye

Drake Maye

112.1

Stafford

Matthew Stafford

107.0

Goff

Jared Goff

22.0

Garrett

Myles Garrett

16.5

Burns

Brian Burns

14.0

Hunter

Danielle Hunter

NFL 2025 Rankings

30.5

29.4

28.9

28.4

28.3

27.9

Opp PPG Rankings

16.6

18.1

18.8

19.3

19.4

19.6

Total Yards Rankings

398.6

396.7

375.8

374.5

370.4

369.4

Rush Yards Rankings

157.8

156.4

149.4

134.2

127.1

126.7

Pass Yards Rankings

287.0

278.6

265.3

264.8

261.9

255.2

64.0

51.0

50.0

48.0

46.0

45.0

NFL Fantasy 2025

Fantasy RB Rankings

312.4

Taylor

Jonathan Taylor

308.9

McCaffrey

Christian McCaffrey

272.6

Gibbs

Jahmyr Gibbs

Fantasy WR Rankings

232.5

Smith-Njigba

Jaxon Smith-Njigba

219.3

Nacua

Puka Nacua

198

Pickens

George Pickens

Fantasy TE Rankings

183.4

McBride

Trey McBride

125.1

Goedert

Dallas Goedert

116

Kelce

Travis Kelce

Fantasy K Rankings

194

Myers

Jason Myers

182.6

Aubrey

Brandon Aubrey

168

Fairbairn

Ka'imi Fairbairn

NFL 2025 Betting

Best Record ATS

11-4

11-5

11-5

11-5

11-5

10-5-1

Worst Record ATS

5-11

5-10-1

6-10

6-10

6-10

6-10

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	13	3	0	.813
Bills - w	11	5	0	.688
Dolphins - e	7	9	0	.438
Jets - e	3	13	0	.188
AFC North	W	L	T	PCT
Steelers	9	7	0	.563
Ravens	8	8	0	.500
Bengals - e	6	10	0	.375
Browns - e	4	12	0	.250
AFC South	W	L	T	PCT
Jaguars - x	12	4	0	.750
Texans - x	11	5	0	.688
Colts - e	8	8	0	.500
Titans - e	3	13	0	.188
AFC West	W	L	T	PCT
Broncos - y	13	3	0	.813
Chargers - w	11	5	0	.688
Chiefs - e	6	10	0	.375
Raiders - e	2	14	0	.125

NFC East	W	L	T	PCT
Eagles - y	11	5	0	.688
Cowboys - e	7	8	1	.469
Commanders - e	4	12	0	.250
Giants - e	3	13	0	.188
NFC North	W	L	T	PCT
Bears - y	11	5	0	.688
Packers - w	9	6	1	.594
Vikings - e	8	8	0	.500
Lions - e	8	8	0	.500
NFC South	W	L	T	PCT
Panthers	8	8	0	.500
Buccaneers	7	9	0	.438
Falcons - e	6	9	0	.400
Saints - e	6	10	0	.375
NFC West	W	L	T	PCT
Seahawks - x	13	3	0	.813
49ers - x	12	4	0	.750
Rams - x	11	4	0	.733
Cardinals - e	3	13	0	.188

NFL 2025 Scores & Schedule

Scores

DATE	MATCHUP			SCORE
Sat 9/27	CAR	@	NE	13-42
Sat 9/27	LAC	@	NYG	18-21
Sat 9/27	JAX	@	SF	26-21
Sat 9/27	IND	@	LAR	20-27
Sat 9/27	CHI	@	LV	25-24

Schedule

DATE	MATCHUP			TIME (ET)
Mon 12/29	LAR	@	ATL	8:15 PM
Sat 1/3	CAR	@	TB	4:30 PM
Sat 1/3	SEA	@	SF	8:00 PM
Sun 1/4	TEN	@	JAX	1:00 PM
Sun 1/4	IND	@	HOU	1:00 PM