The San Francisco 49ers have a record of 4-7 against the AFC West in the regular-season and playoffs since 2017.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/23/2018 | 0-1 | @ | L 27-38 | .000 | 3 | 26 | 406 | 384 | 22.2 | 100.0 | ||
| 2 | | 49ers | 9/30/2018 | 0-1 | @ | L 27-29 | .000 | 3 | 22 | 364 | 368 | 41.7 | |||
| 3 | | 49ers | 11/1/2018 | 1-0 | vs | W 34-3 | 1.000 | 4 | 18 | 405 | 242 | 41.7 | |||
| 4 | | 49ers | 12/9/2018 | 1-0 | vs | W 20-14 | 1.000 | 2 | 24 | 389 | 274 | 30.8 | 0.0 | ||
| 5 | | 49ers | 2/2/2020 | 0-1 | @ | L 20-31 | .000 | 2 | 21 | 351 | 397 | 37.5 | 0.0 | ||
| 6 | | 49ers | 9/25/2022 | 0-1 | @ | L 10-11 | .000 | 1 | 13 | 267 | 261 | 10.0 | |||
| 7 | | 49ers | 10/23/2022 | 0-1 | vs | L 23-44 | .000 | 2 | 25 | 444 | 529 | 57.1 | |||
| 8 | | 49ers | 11/13/2022 | 1-0 | vs | W 22-16 | 1.000 | 2 | 22 | 387 | 238 | 52.9 | 100.0 | ||
| 9 | | 49ers | 1/1/2023 | 1-0 | @ | W 37-34 | 1.000 | 4 | 27 | 454 | 500 | 50.0 | |||
| 10 | | 49ers | 2/11/2024 | 0-1 | @ | L 22-25 | .000 | 2 | 23 | 382 | 455 | 25.0 | 100.0 | ||
| 11 | | 49ers | 10/20/2024 | 0-1 | vs | L 18-28 | .000 | 2 | 19 | 310 | 329 | 18.2 | 100.0 | ||
| Average | .364 | 2.5 | 21.8 | 378.1 | 361.5 | 36.5 | 11.9 | ||||||||
| Total | 4-7 | .364 | 27 | 240 | 4,159 | 3,977 | 36.5 | 71.4 |
More 49ers Stats
Team Leaders 
PASS
2,151
Jones
RUSH
1,039
McCaffrey
REC
849
McCaffrey
Team Rankings
PPG
26.1
9th
OPP PPG
21.3
12th
RUSH YDS/G
104.3
25th
PASS YDS/G
259.2
5th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - x | 12 | 3 | 0 | .800 |
 Bills - x | 11 | 4 | 0 | .733 |
 Dolphins - e | 6 | 9 | 0 | .400 |
 Jets - e | 3 | 12 | 0 | .200 |
| AFC North | W | L | T | PCT |
9 | 6 | 0 | .600 | |
7 | 8 | 0 | .467 | |
 Bengals - e | 5 | 10 | 0 | .333 |
 Browns - e | 3 | 12 | 0 | .200 |
| AFC South | W | L | T | PCT |
 Jaguars - x | 11 | 4 | 0 | .733 |
10 | 5 | 0 | .667 | |
8 | 7 | 0 | .533 | |
 Titans - e | 3 | 12 | 0 | .200 |
| AFC West | W | L | T | PCT |
 Broncos - x | 13 | 3 | 0 | .813 |
 Chargers - x | 11 | 4 | 0 | .733 |
 Chiefs - e | 6 | 10 | 0 | .375 |
 Raiders - e | 2 | 13 | 0 | .133 |
Steelers
Ravens
Texans
Colts| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 10 | 5 | 0 | .667 |
 Cowboys - e | 7 | 8 | 1 | .469 |
 Commanders - e | 4 | 12 | 0 | .250 |
 Giants - e | 2 | 13 | 0 | .133 |
| NFC North | W | L | T | PCT |
 Bears - x | 11 | 4 | 0 | .733 |
 Packers - x | 9 | 5 | 1 | .633 |
 Vikings - e | 8 | 8 | 0 | .500 |
 Lions - e | 8 | 8 | 0 | .500 |
| NFC South | W | L | T | PCT |
8 | 7 | 0 | .533 | |
7 | 8 | 0 | .467 | |
 Falcons - e | 6 | 9 | 0 | .400 |
 Saints - e | 5 | 10 | 0 | .333 |
| NFC West | W | L | T | PCT |
 Seahawks - x | 12 | 3 | 0 | .800 |
 49ers - x | 11 | 4 | 0 | .733 |
 Rams - x | 11 | 4 | 0 | .733 |
 Cardinals - e | 3 | 12 | 0 | .200 |
Panthers
Buccaneers
