The San Francisco 49ers were 13-6-1 against the spread against the NFC in Week 1 between the 2002 and 2021 seasons.
Interpreted as:
49ers week 1 or more ats vs nfc 2002 to 2021| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/5/2002 | 0-1 | @ | W 16-13 | -3.5 | -0.5 (N) | 38.5 | -9.5 (U) | 1 | 13 | 279 | 361 | 33.3 | |||||
| 2 | | 49ers | 9/7/2003 | 1-0 | vs | W 49-7 | -6.5 | +35.5 (Y) | 40.5 | +15.5 (O) | 5 | 23 | 391 | 127 | 50.0 | 0.0 | ||||
| 3 | | 49ers | 9/12/2004 | 1-0 | vs | L 19-21 | +3 | +1 (Y) | 43.5 | -3.5 (U) | 2 | 21 | 359 | 227 | 41.2 | 100.0 | ||||
| 4 | | 49ers | 9/11/2005 | 1-0 | vs | W 28-25 | +6 | +9 (Y) | 46.5 | +6.5 (O) | 4 | 12 | 217 | 405 | 14.3 | |||||
| 5 | | 49ers | 9/10/2006 | 1-0 | +400 | @ | -550 | L 27-34 | +8 | +1 (Y) | 43 | +18 (O) | 3 | 19 | 393 | 367 | 11.1 | 100.0 | ||
| 6 | | 49ers | 9/10/2007 | 0-0-1 | -195 | vs | +170 | W 20-17 | -3 | 0 (P) | 45 | -8 (U) | 2 | 16 | 194 | 261 | 25.0 | 100.0 | ||
| 7 | | 49ers | 9/7/2008 | 0-1 | +115 | vs | -135 | L 13-23 | +2.5 | -7.5 (N) | 41.5 | -5.5 (U) | 1 | 13 | 291 | 285 | 37.5 | |||
| 8 | | 49ers | 9/13/2009 | 1-0 | +190 | @ | -230 | W 20-16 | +6 | +10 (Y) | 46 | -10 (U) | 2 | 13 | 203 | 299 | 38.9 | |||
| 9 | | 49ers | 9/12/2010 | 0-1 | -175 | @ | +155 | L 6-31 | -3 | -28 (N) | 37 | 0 (P) | 0 | 14 | 263 | 242 | 6.7 | 66.7 | ||
| 10 | | 49ers | 9/11/2011 | 1-0 | -250 | vs | +210 | W 33-17 | -6 | +10 (Y) | 37.5 | +12.5 (O) | 3 | 12 | 209 | 219 | 8.3 | |||
| 11 | | 49ers | 9/9/2012 | 1-0 | +225 | @ | -265 | W 30-22 | +5 | +13 (Y) | 45 | +7 (O) | 3 | 22 | 377 | 324 | 22.2 | |||
| 12 | | 49ers | 9/8/2013 | 1-0 | -240 | vs | +200 | W 34-28 | -5 | +1 (Y) | 47 | +15 (O) | 4 | 23 | 494 | 385 | 50.0 | 100.0 | ||
| 13 | | 49ers | 9/7/2014 | 1-0 | -175 | @ | +155 | W 28-17 | -3.5 | +7.5 (Y) | 49 | -4 (U) | 4 | 19 | 319 | 382 | 58.3 | |||
| 14 | | 49ers | 9/14/2015 | 1-0 | +120 | vs | -142 | W 20-3 | +2 | +19 (Y) | 42 | -19 (U) | 2 | 25 | 395 | 248 | 41.7 | |||
| 15 | | 49ers | 9/12/2016 | 1-0 | +125 | vs | -145 | W 28-0 | +3 | +31 (Y) | 42.5 | -14.5 (U) | 4 | 28 | 320 | 185 | 47.1 | 50.0 | ||
| 16 | | 49ers | 9/10/2017 | 0-1 | +185 | vs | -200 | L 3-23 | +4.5 | -15.5 (N) | 45 | -19 (U) | 0 | 13 | 217 | 287 | 18.2 | 25.0 | ||
| 17 | | 49ers | 9/9/2018 | 0-1 | +240 | @ | -260 | L 16-24 | +6 | -2 (N) | 46.5 | -6.5 (U) | 1 | 20 | 327 | 343 | 38.5 | |||
| 18 | | 49ers | 9/8/2019 | 1-0 | -104 | @ | -118 | W 31-17 | +1 | +15 (Y) | 51 | -3 (U) | 3 | 17 | 256 | 295 | 38.5 | |||
| 19 | | 49ers | 9/13/2020 | 0-1 | -312 | vs | +245 | L 20-24 | -6.5 | -10.5 (N) | 48 | -4 (U) | 2 | 18 | 366 | 404 | 18.2 | 0.0 | ||
| 20 | | 49ers | 9/12/2021 | 1-0 | -371 | @ | +285 | W 41-33 | -7.5 | +0.5 (Y) | 45 | +29 (O) | 5 | 21 | 442 | 430 | 33.3 | |||
| Average | 3.4 | 2.6 | 18.1 | 315.6 | 303.8 | 33.5 | 0.1 | |||||||||||||
| Total | 13-6-1 | 51 | 362 | 6,312 | 6,076 | 33.5 | 50.0 |
CHI
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |