Since 2019, the San Francisco 49ers have their lowest point differential in a game versus the Packers on November 24, 2024, with a -28-point differential.
Interpreted as:
49ers worst loss in a regular-season game ever since 2019| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | -28 | 11/24/2024 | @ | L 10-38 | 1 | 11 | 241 | 325 | 30.0 | 0.0 | ||
| 2 | | 49ers | -26 | 10/11/2020 | vs | L 17-43 | 2 | 19 | 259 | 436 | 20.0 | 0.0 | ||
| 3 | | 49ers | -25 | 12/1/2024 | @ | L 10-35 | 1 | 15 | 239 | 372 | 30.0 | 100.0 | ||
| 4 | | 49ers | -23 | 1/5/2025 | @ | L 24-47 | 3 | 26 | 436 | 393 | 38.5 | 50.0 | ||
| 5 | | 49ers | -21 | 10/23/2022 | vs | L 23-44 | 2 | 25 | 444 | 529 | 57.1 | |||
| 6 | | 49ers | -17 | 11/5/2020 | vs | L 17-34 | 2 | 17 | 337 | 405 | 30.0 | 0.0 | ||
| 7 | | 49ers | -16 | 11/9/2025 | vs | L 26-42 | 4 | 24 | 393 | 401 | 37.5 | 33.3 | ||
| 8 | | 49ers | -14 | 12/25/2023 | vs | L 19-33 | 2 | 21 | 429 | 343 | 42.9 | 33.3 | ||
| 9 | | 49ers | -14 | 10/29/2023 | vs | L 17-31 | 2 | 24 | 460 | 400 | 55.6 | |||
| 10 | | 49ers | -14 | 10/16/2022 | @ | L 14-28 | 2 | 21 | 346 | 289 | 37.5 | 0.0 | ||
| 11 | | 49ers | -14 | 11/7/2021 | vs | L 17-31 | 2 | 22 | 337 | 437 | 40.0 | |||
| 12 | | 49ers | -14 | 11/15/2020 | @ | L 13-27 | 1 | 21 | 281 | 237 | 43.8 | 0.0 | ||
| 13 | | 49ers | -12 | 12/22/2024 | @ | L 17-29 | 2 | 20 | 374 | 381 | 38.5 | 0.0 | ||
| 14 | | 49ers | -12 | 10/24/2021 | vs | L 18-30 | 2 | 13 | 280 | 295 | 9.1 | |||
| 15 | | 49ers | -11 | 10/26/2025 | @ | L 15-26 | 2 | 12 | 223 | 475 | 33.3 | 0.0 | ||
| 16 | | 49ers | -11 | 10/12/2025 | @ | L 19-30 | 1 | 17 | 363 | 352 | 43.8 | 0.0 | ||
| 17 | | 49ers | -10 | 10/20/2024 | vs | L 18-28 | 2 | 19 | 310 | 329 | 18.2 | 100.0 | ||
| 18 | | 49ers | -10 | 12/7/2020 | vs | L 24-34 | 3 | 24 | 402 | 449 | 54.5 | 0.0 | ||
| 19 | | 49ers | -10 | 11/1/2020 | @ | L 27-37 | 4 | 24 | 351 | 350 | 46.2 | 100.0 | ||
| 20 | | 49ers | -9 | 9/11/2022 | @ | L 10-19 | 1 | 17 | 331 | 204 | 47.1 | 0.0 | ||
| 21 | | 49ers | -8 | 12/20/2020 | @ | L 33-41 | 4 | 28 | 458 | 291 | 40.0 | 100.0 | ||
| 22 | | 49ers | -8 | 12/13/2020 | vs | L 15-23 | 2 | 21 | 344 | 193 | 26.7 | 0.0 | ||
| 23 | | 49ers | -7 | 12/5/2021 | @ | L 23-30 | 3 | 17 | 365 | 327 | 30.0 | 50.0 | ||
| 24 | | 49ers | -7 | 10/10/2021 | @ | L 10-17 | 1 | 19 | 338 | 304 | 27.3 | 20.0 | ||
| 25 | | 49ers | -7 | 10/3/2021 | vs | L 21-28 | 3 | 23 | 457 | 234 | 14.3 | 75.0 | ||
BAL
TB
CHI
WASMore 49ers Stats
Team Leaders 
PASS
2,151
Jones
RUSH
1,179
McCaffrey
REC
890
McCaffrey
Team Rankings
PPG
27.1
8th
OPP PPG
22.4
13th
RUSH YDS/G
110.3
22nd
PASS YDS/G
261.9
5th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 13 | 3 | 0 | .813 |
 Bills - w | 11 | 5 | 0 | .688 |
 Dolphins - e | 7 | 9 | 0 | .438 |
 Jets - e | 3 | 13 | 0 | .188 |
| AFC North | W | L | T | PCT |
9 | 7 | 0 | .563 | |
8 | 8 | 0 | .500 | |
 Bengals - e | 6 | 10 | 0 | .375 |
 Browns - e | 4 | 12 | 0 | .250 |
| AFC South | W | L | T | PCT |
 Jaguars - x | 12 | 4 | 0 | .750 |
 Texans - x | 11 | 5 | 0 | .688 |
 Colts - e | 8 | 8 | 0 | .500 |
 Titans - e | 3 | 13 | 0 | .188 |
| AFC West | W | L | T | PCT |
 Broncos - y | 13 | 3 | 0 | .813 |
 Chargers - w | 11 | 5 | 0 | .688 |
 Chiefs - e | 6 | 10 | 0 | .375 |
 Raiders - e | 2 | 14 | 0 | .125 |
Steelers| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 5 | 0 | .688 |
 Cowboys - e | 7 | 8 | 1 | .469 |
 Commanders - e | 4 | 12 | 0 | .250 |
 Giants - e | 3 | 13 | 0 | .188 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 5 | 0 | .688 |
 Packers - w | 9 | 6 | 1 | .594 |
 Vikings - e | 8 | 8 | 0 | .500 |
 Lions - e | 8 | 8 | 0 | .500 |
| NFC South | W | L | T | PCT |
8 | 8 | 0 | .500 | |
7 | 9 | 0 | .438 | |
 Falcons - e | 7 | 9 | 0 | .438 |
 Saints - e | 6 | 10 | 0 | .375 |
| NFC West | W | L | T | PCT |
 Seahawks - x | 13 | 3 | 0 | .813 |
 49ers - x | 12 | 4 | 0 | .750 |
 Rams - w | 11 | 5 | 0 | .688 |
 Cardinals - e | 3 | 13 | 0 | .188 |
Panthers
