Fred Dryer has scored the most safeties in a game, with 2 safeties versus the Packers on October 21, 1973.

Interpreted as:

best safety by a player performance in a regular-season game

	NAME	SFTY	DATE	TM		OPP	TKL	AST	COMB	SCK	SCKY	INT	INT YDS	INT TD	FF	FR	FR TD
1	Fred Dryer F. Dryer	2	10/21/1973	LA	vs	GB						0	0	0			0
2	Tyree Wilson T. Wilson	1	1/4/2026	LV	vs	KC	5	1	6	2.0	29	0	0	0	2	0	0
3	Jeffery Simmons J. Simmons	1	12/21/2025	TEN	vs	KC	2	1	3	0.0	0	0	0	0	0	0	0
4	Kyle Dugger K. Dugger	1	12/21/2025	PIT	@	DET	6	1	7	1.0	5	0	0	0	0	0	0
5	Josh Hines-Allen J. Hines-Allen	1	12/7/2025	JAX	vs	IND	2	3	5	1.0	9	0	0	0	0	0	0
6	Donovan Ezeiruaku D. Ezeiruaku	1	11/17/2025	DAL	@	LV	3	2	5	0.0	0	0	0	0	0	0	0
7	Khalil Mack K. Mack	1	11/9/2025	LAC	vs	PIT	1	2	3	1.0	9	0	0	0	1	0	0
8	Daron Payne D. Payne	1	10/19/2025	WAS	@	DAL	1	4	5	0.0	0	0	0	0	0	0	0
9	Derrick Barnes D. Barnes	1	10/5/2025	DET	@	CIN	5	3	8	1.0	7	0	0	0	0	0	0
10	Kaevon Merriweather K. Merriweather	1	9/28/2025	TB	vs	PHI	1	1	2	0.0	0	0	0	0	0	0	0
11	A.J. Epenesa	1	12/29/2024	BUF	vs	NYJ	4	0	4	1.0	2	0	0	0	0	0	0
12	Kamari Lassiter K. Lassiter	1	12/25/2024	HOU	vs	BAL	3	3	6	0.0	0	0	0	0	0	0	0
13	Zach Harrison Z. Harrison	1	12/16/2024	ATL	@	LV	2	2	4	1.0	2	0	0	0	0	0	0
14	Harold Landry III H. Landry III	1	11/24/2024	TEN	@	HOU	3	0	3	1.0	1	0	0	0	0	0	0
15	Byron Young B. Young	1	10/24/2024	LAR	vs	MIN	1	1	2	1.0	5	0	0	0	0	0	0
16	Sam Hubbard S. Hubbard	1	10/6/2024	CIN	vs	BAL	7	2	9	1.0	3	0	0	0	0	0	0
17	Dre'Mont Jones D. Jones	1	9/30/2024	SEA	@	DET	1	1	2	1.0	4	0	0	0	0	0	0
18	Alex Wright A. Wright	1	9/15/2024	CLE	@	JAX	2	1	3	1.0	2	0	0	0	0	0	0
19	Zach Allen Z. Allen	1	9/8/2024	DEN	@	SEA	1	1	2	0.0	0	0	0	0	0	0	0
20	Ameer Speed A. Speed	1	1/6/2024	IND	vs	HOU	1	0	1	0.0	0	0	0	0	0	0	0
21	Pat O'Connor P. O'Connor	1	12/10/2023	TB	@	ATL	1	0	1	0.0	0	0	0	0	0	0	0
22	Ashtyn Davis A. Davis	1	12/3/2023	NYJ	vs	ATL	2	0	2	0.0	0	0	0	0	0	0	0
23	Calais Campbell C. Campbell	1	11/5/2023	ATL	vs	MIN	4	0	4	1.0	5	0	0	0	0	0	0
24	Sam Williams S. Williams	1	10/29/2023	DAL	vs	LAR	1	1	2	0.0	0	0	0	0	0	0	0
25	Miles Killebrew M. Killebrew	1	10/8/2023	PIT	vs	BAL	1	0	1	0.0	0	0	0	0	0	0	0

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Results may be incomplete. StatMuse has complete game-level data for safeties going back to the 1960 season.

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Fred Dryer has scored the most safeties in a game, with 2 safeties versus the Packers on October 21, 1973.

Interpreted as:

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