The Buffalo Bills are 57-41 as favorites against the AFC in the regular-season and playoffs on the road all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/19/1980 | 0-1 | @ | L 14-17 | .000 | 2 | 18 | 289 | 232 | ||||
| 2 | | Bills | 11/9/1980 | 1-0 | @ | W 31-24 | 1.000 | 4 | 17 | 274 | 267 | ||||
| 3 | | Bills | 11/16/1980 | 1-0 | @ | W 14-0 | 1.000 | 2 | 22 | 306 | 213 | ||||
| 4 | | Bills | 11/30/1980 | 0-1 | @ | L 24-28 | .000 | 3 | 24 | 284 | 201 | ||||
| 5 | | Bills | 9/13/1981 | 1-0 | @ | W 35-3 | 1.000 | 5 | 26 | 430 | 147 | ||||
| 6 | | Bills | 9/27/1981 | 0-1 | @ | L 24-27 | .000 | 3 | 25 | 389 | 429 | ||||
| 7 | | Bills | 10/18/1981 | 0-1 | @ | L 14-33 | .000 | 2 | 14 | 288 | 374 | ||||
| 8 | | Bills | 12/13/1981 | 1-0 | @ | W 19-10 | 1.000 | 2 | 20 | 329 | 204 | ||||
| 9 | | Bills | 1/2/1983 | 0-1 | @ | L 19-30 | .000 | 2 | 17 | 353 | 418 | ||||
| 10 | | Bills | 10/16/1983 | 1-0 | @ | W 30-7 | 1.000 | 3 | 23 | 401 | 284 | ||||
| 11 | | Bills | 12/14/1986 | 0-1 | @ | L 14-24 | .000 | 2 | 18 | 358 | 375 | ||||
| 12 | | Bills | 11/14/1988 | 1-0 | @ | W 31-6 | 1.000 | 4 | 29 | 416 | 257 | ||||
| 13 | | Bills | 12/18/1988 | 0-1 | @ | L 14-17 | .000 | 2 | 14 | 248 | 301 | ||||
| 14 | | Bills | 9/10/1989 | 1-0 | @ | W 27-24 | 1.000 | 3 | 27 | 367 | 323 | ||||
| 15 | | Bills | 10/8/1989 | 0-1 | @ | L 14-37 | .000 | 2 | 25 | 424 | 330 | ||||
| 16 | | Bills | 11/19/1989 | 0-1 | @ | L 24-33 | .000 | 3 | 24 | 424 | 359 | ||||
| 17 | | Bills | 12/4/1989 | 0-1 | @ | L 16-17 | .000 | 1 | 11 | 232 | 355 | ||||
| 18 | | Bills | 12/23/1989 | 1-0 | @ | W 37-0 | 1.000 | 5 | 28 | 441 | 200 | ||||
| 19 | | Bills | 9/16/1990 | 0-1 | @ | L 7-30 | .000 | 1 | 12 | 205 | 305 | ||||
| 20 | | Bills | 10/28/1990 | 1-0 | @ | W 27-10 | 1.000 | 3 | 19 | 353 | 262 | ||||
| 21 | | Bills | 11/4/1990 | 1-0 | @ | W 42-0 | 1.000 | 6 | 24 | 310 | 234 | ||||
| 22 | | Bills | 12/9/1990 | 1-0 | @ | W 31-7 | 1.000 | 4 | 23 | 408 | 127 | ||||
| 23 | | Bills | 9/15/1991 | 1-0 | @ | W 23-20 | 1.000 | 2 | 22 | 304 | 388 | 22.2 | 100.0 | ||
| 24 | | Bills | 10/7/1991 | 0-1 | @ | L 6-33 | .000 | 0 | 11 | 211 | 389 | 28.6 | |||
| 25 | | Bills | 11/18/1991 | 1-0 | @ | W 41-27 | 1.000 | 5 | 27 | 433 | 392 | 56.3 | |||
| Average | .582 | 2.6 | 20.7 | 346.5 | 304.3 | ||||||||||
| Total | 57-41 | .582 | 259 | 2,029 | 33,959 | 29,818 | |||||||||
BALMore NFL News
Former Buffalo Bills quarterback Jim Kelly says he was hospitalized after a stroke in the spring
Falcons agree to $54 million, 3-year deal that makes Kyle Pitts Sr. 1 of NFL's top paid tight ends
Bills owner Terry Pegula helps open team's new $2.1 billion stadium
Brendan Sorsby has to wait until 2027 to join the NFL
Jeffery Simmons cashes in on big season by signing record-setting, 3-year deal with Titans
Dexter Lawrence looking to keep same offseason approach before reporting to Bengals' training camp
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |