The Buffalo Bills have a 57-41 record as favorites against the AFC in the regular-season and playoffs on the road all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/19/1980 | 0-1 | @ | L 14-17 | .000 | 2 | 18 | 289 | 232 | ||||
| 2 | | Bills | 11/9/1980 | 1-0 | @ | W 31-24 | 1.000 | 4 | 17 | 274 | 267 | ||||
| 3 | | Bills | 11/16/1980 | 1-0 | @ | W 14-0 | 1.000 | 2 | 22 | 306 | 213 | ||||
| 4 | | Bills | 11/30/1980 | 0-1 | @ | L 24-28 | .000 | 3 | 24 | 284 | 201 | ||||
| 5 | | Bills | 9/13/1981 | 1-0 | @ | W 35-3 | 1.000 | 5 | 26 | 430 | 147 | ||||
| 6 | | Bills | 9/27/1981 | 0-1 | @ | L 24-27 | .000 | 3 | 25 | 389 | 429 | ||||
| 7 | | Bills | 10/18/1981 | 0-1 | @ | L 14-33 | .000 | 2 | 14 | 288 | 374 | ||||
| 8 | | Bills | 12/13/1981 | 1-0 | @ | W 19-10 | 1.000 | 2 | 20 | 329 | 204 | ||||
| 9 | | Bills | 1/2/1983 | 0-1 | @ | L 19-30 | .000 | 2 | 17 | 353 | 418 | ||||
| 10 | | Bills | 10/16/1983 | 1-0 | @ | W 30-7 | 1.000 | 3 | 23 | 401 | 284 | ||||
| 11 | | Bills | 12/14/1986 | 0-1 | @ | L 14-24 | .000 | 2 | 18 | 358 | 375 | ||||
| 12 | | Bills | 11/14/1988 | 1-0 | @ | W 31-6 | 1.000 | 4 | 29 | 416 | 257 | ||||
| 13 | | Bills | 12/18/1988 | 0-1 | @ | L 14-17 | .000 | 2 | 14 | 248 | 301 | ||||
| 14 | | Bills | 9/10/1989 | 1-0 | @ | W 27-24 | 1.000 | 3 | 27 | 367 | 323 | ||||
| 15 | | Bills | 10/8/1989 | 0-1 | @ | L 14-37 | .000 | 2 | 25 | 424 | 330 | ||||
| 16 | | Bills | 11/19/1989 | 0-1 | @ | L 24-33 | .000 | 3 | 24 | 424 | 359 | ||||
| 17 | | Bills | 12/4/1989 | 0-1 | @ | L 16-17 | .000 | 1 | 11 | 232 | 355 | ||||
| 18 | | Bills | 12/23/1989 | 1-0 | @ | W 37-0 | 1.000 | 5 | 28 | 441 | 200 | ||||
| 19 | | Bills | 9/16/1990 | 0-1 | @ | L 7-30 | .000 | 1 | 12 | 205 | 305 | ||||
| 20 | | Bills | 10/28/1990 | 1-0 | @ | W 27-10 | 1.000 | 3 | 19 | 353 | 262 | ||||
| 21 | | Bills | 11/4/1990 | 1-0 | @ | W 42-0 | 1.000 | 6 | 24 | 310 | 234 | ||||
| 22 | | Bills | 12/9/1990 | 1-0 | @ | W 31-7 | 1.000 | 4 | 23 | 408 | 127 | ||||
| 23 | | Bills | 9/15/1991 | 1-0 | @ | W 23-20 | 1.000 | 2 | 22 | 304 | 388 | 22.2 | 100.0 | ||
| 24 | | Bills | 10/7/1991 | 0-1 | @ | L 6-33 | .000 | 0 | 11 | 211 | 389 | 28.6 | |||
| 25 | | Bills | 11/18/1991 | 1-0 | @ | W 41-27 | 1.000 | 5 | 27 | 433 | 392 | 56.3 | |||
| Average | .582 | 2.6 | 20.7 | 346.5 | 304.3 | ||||||||||
| Total | 57-41 | .582 | 259 | 2,029 | 33,959 | 29,818 | |||||||||
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |