The Buffalo Bills had a 21-22-2 record against the spread against the AFC South between the 2002 and 2022 seasons.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/13/2002 | 0-1 |  BUF | @ |  HOU | W 31-24 | -7.5 | -0.5 (N) | 44 | +11 (O) | 4 | 25 | 403 | 338 | 42.9 | |||
| 2 | | Bills | 9/14/2003 | 1-0 | BUF | @ |  JAX | W 38-17 | -2.5 | +18.5 (Y) | 43 | +12 (O) | 5 | 20 | 371 | 287 | 57.1 | 50.0 | ||
| 3 | | Bills | 11/16/2003 | 0-1 | BUF | vs | HOU | L 10-12 | -7 | -9 (N) | 37.5 | -15.5 (U) | 0 | 17 | 335 | 245 | 23.1 | |||
| 4 | | Bills | 11/23/2003 | 0-0-1 | BUF | vs |  IND | L 14-17 | +3 | 0 (P) | 37.5 | -6.5 (U) | 2 | 16 | 228 | 326 | 23.1 | 100.0 | ||
| 5 | | Bills | 12/14/2003 | 1-0 | BUF | @ |  TEN | L 26-28 | +6 | +4 (Y) | 38 | +16 (O) | 3 | 13 | 241 | 349 | 16.7 | 100.0 | ||
| 6 | | Bills | 9/12/2004 | 0-1 | BUF | vs | JAX | L 10-13 | -3 | -6 (N) | 35.5 | -12.5 (U) | 1 | 16 | 242 | 225 | 50.0 | |||
| 7 | | Bills | 9/11/2005 | 1-0 | BUF | vs | HOU | W 22-7 | -5.5 | +9.5 (Y) | 38 | -9 (U) | 1 | 20 | 316 | 120 | 21.4 | 100.0 | ||
| 8 | | Bills | 11/12/2006 | 1-0 | BUF | +525 | @ | IND | -725 | L 16-17 | +12 | +11 (Y) | 45 | -12 (U) | 1 | 10 | 162 | 384 | 35.7 | 100.0 |
| 9 | | Bills | 11/19/2006 | 1-0 | BUF | +135 | @ | HOU | -155 | W 24-21 | +2 | +5 (Y) | 36 | +9 (O) | 3 | 17 | 403 | 394 | 28.6 | 100.0 |
| 10 | | Bills | 11/26/2006 | 1-0 | BUF | +140 | vs | JAX | -160 | W 27-24 | +3 | +6 (Y) | 35 | +16 (O) | 3 | 13 | 241 | 323 | 30.0 | |
| 11 | | Bills | 12/24/2006 | 0-1 | BUF | -220 | vs | TEN | +180 | L 29-30 | -5 | -6 (N) | 37 | +22 (O) | 2 | 22 | 368 | 396 | 20.0 | 50.0 |
| 12 | | Bills | 11/25/2007 | 0-1 | BUF | +325 | @ | JAX | -430 | L 14-36 | +8.5 | -13.5 (N) | 37 | +13 (O) | 2 | 20 | 297 | 416 | 56.3 | 50.0 |
| 13 | | Bills | 9/14/2008 | 1-0 | BUF | +170 | @ | JAX | -200 | W 20-16 | +4.5 | +8.5 (Y) | 37 | -1 (U) | 2 | 18 | 285 | 243 | 54.5 | |
| 14 | | Bills | 11/1/2009 | 0-1 | BUF | +165 | vs | HOU | -190 | L 10-31 | +3 | -18 (N) | 41.5 | -0.5 (U) | 1 | 9 | 204 | 439 | 20.0 | 0.0 |
| 15 | | Bills | 11/15/2009 | 0-1 | BUF | +300 | @ | TEN | -360 | L 17-41 | +8 | -16 (N) | 40.5 | +17.5 (O) | 2 | 14 | 296 | 378 | 35.7 | 0.0 |
| 16 | | Bills | 11/22/2009 | 1-0 | BUF | +310 | @ | JAX | -375 | L 15-18 | +8.5 | +5.5 (Y) | 43 | -10 (U) | 1 | 14 | 343 | 310 | 27.3 | 0.0 |
| 17 | | Bills | 1/3/2010 | 1-0 | BUF | -380 | vs | IND | +310 | W 30-7 | -8.5 | +14.5 (Y) | 32.5 | +4.5 (O) | 3 | 19 | 403 | 157 | 35.7 | |
| 18 | | Bills | 10/10/2010 | 0-1 | BUF | -140 | vs | JAX | +120 | L 26-36 | -1 | -11 (N) | 41 | +21 (O) | 3 | 17 | 306 | 381 | 27.3 | 0.0 |
| 19 | | Bills | 12/4/2011 | 0-1 | BUF | -120 | vs | TEN | +100 | L 17-23 | -1 | -7 (N) | 42.5 | -2.5 (U) | 2 | 18 | 386 | 317 | 43.8 | 50.0 |
| 20 | | Bills | 10/21/2012 | 0-1 | BUF | -215 | vs | TEN | +185 | L 34-35 | -4 | -5 (N) | 46.5 | +22.5 (O) | 4 | 22 | 382 | 390 | 58.3 | 0.0 |
| 21 | | Bills | 11/4/2012 | 0-1 | BUF | +450 | @ | HOU | -600 | L 9-21 | +11 | -1 (N) | 48 | -18 (U) | 0 | 17 | 304 | 374 | 18.2 | 100.0 |
| 22 | | Bills | 11/25/2012 | 0-1 | BUF | +115 | @ | IND | -135 | L 13-20 | +2 | -5 (N) | 51 | -18 (U) | 1 | 16 | 304 | 312 | 30.8 | |
| 23 | | Bills | 12/2/2012 | 1-0 | BUF | -265 | vs | JAX | +225 | W 34-18 | -6 | +10 (Y) | 41 | +11 (O) | 4 | 20 | 344 | 236 | 41.7 | 0.0 |
| 24 | | Bills | 12/15/2013 | 1-0 | BUF | -205 | @ | JAX | +175 | W 27-20 | -4 | +3 (Y) | 43.5 | +3.5 (O) | 3 | 25 | 366 | 354 | 38.5 | |
| 25 | | Bills | 9/28/2014 | 0-1 | BUF | +130 | @ | HOU | -150 | L 17-23 | +3 | -3 (N) | 44 | -4 (U) | 2 | 17 | 316 | 301 | 31.3 | |
| Average | 1.1 | 2.2 | 18.1 | 322.8 | 307.5 | 38.4 | 1.7 | |||||||||||||
| Total | 21-22-2 | 100 | 816 | 14,528 | 13,839 | 38.4 | 47.7 | |||||||||||||
StatMuse has team, game-level data for spread records going back to the 1979 season.
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 Eagles | 11 | 2 | 0 | .846 |
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| NFC North | W | L | T | PCT |
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