The Buffalo Bills had their most points in a Week-2 game with Josh Allen versus the Titans on September 19, 2022, with 41 points.
| TEAM | PTS | DATE | TM | OPP | RESULT | PASS TD | RUSH TD | RET TD | TD | FGM | XPM | XP2 | SFTY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 41 | 9/19/2022 |  BUF | vs |  TEN | W 41-7 | 4 | 0 | 1 | 5 | 2 | 5 | 0 | 0 |
| 2 | | Bills | 38 | 9/17/2023 | BUF | vs |  LV | W 38-10 | 3 | 2 | 0 | 5 | 1 | 5 | 0 | 0 |
| 3 | | Bills | 35 | 9/19/2021 | BUF | @ |  MIA | W 35-0 | 2 | 3 | 0 | 5 | 0 | 5 | 0 | 0 |
| 4 | | Bills | 31 | 9/12/2024 | BUF | @ | MIA | W 31-10 | 1 | 2 | 1 | 4 | 1 | 4 | 0 | 0 |
| 5 | | Bills | 31 | 9/20/2020 | BUF | @ | MIA | W 31-28 | 4 | 0 | 0 | 4 | 1 | 4 | 0 | 0 |
| 6 | | Bills | 30 | 9/14/2025 | BUF | @ |  NYJ | W 30-10 | 0 | 3 | 0 | 3 | 3 | 3 | 0 | 0 |
| 7 | | Bills | 28 | 9/15/2019 | BUF | @ |  NYG | W 28-14 | 1 | 3 | 0 | 4 | 0 | 4 | 0 | 0 |
| 8 | | Bills | 20 | 9/16/2018 | BUF | vs |  LAC | L 20-31 | 1 | 1 | 0 | 2 | 2 | 2 | 0 | 0 |
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