The Buffalo Bills had their most yards from scrimmage in a game versus the Dolphins on December 24, 2016, with 601 yards.
Interpreted as:
buffalo bills most yards from scrimmage in a regular-season game| TEAM | YDS | DATE | TM | OPP | RUSH YDS | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 601 | 12/24/2016 | vs | 272 | 49 | 5.6 | 1 | 329 | 26 | 39 | 12.7 | 3 | ||
| 2 | | Bills | 582 | 9/1/1991 | vs | 185 | 33 | 5.6 | 2 | 397 | 31 | 12.8 | 3 | |||
| 3 | | Bills | 579 | 12/23/2000 | @ | 213 | 37 | 5.8 | 3 | 366 | 20 | 25 | 18.3 | 3 | ||
| 4 | | Bills | 565 | 10/11/1964 | @ | 160 | 37 | 4.3 | 3 | 405 | 16 | 25.3 | 3 | |||
| 5 | | Bills | 559 | 12/15/2024 | @ | 197 | 34 | 5.8 | 4 | 362 | 23 | 32 | 15.7 | 2 | ||
| 6 | | Bills | 557 | 9/8/1991 | vs | 194 | 40 | 4.9 | 0 | 363 | 31 | 11.7 | 6 | |||
| 7 | | Bills | 552 | 10/9/2022 | vs | 120 | 18 | 6.7 | 1 | 432 | 22 | 36 | 19.6 | 4 | ||
| 8 | | Bills | 541 | 12/19/2020 | @ | 182 | 24 | 7.6 | 3 | 359 | 28 | 38 | 12.8 | 2 | ||
| 9 | | Bills | 527 | 9/20/2020 | @ | 112 | 23 | 4.9 | 0 | 415 | 24 | 35 | 17.3 | 4 | ||
| 10 | | Bills | 527 | 10/24/1964 | vs | 180 | 37 | 4.9 | 2 | 347 | 12 | 28.9 | 2 | |||
| 11 | | Bills | 516 | 9/23/1979 | vs | 149 | 38 | 3.9 | 0 | 367 | 19 | 19.3 | 5 | |||
| 12 | | Bills | 515 | 9/25/2022 | @ | 115 | 23 | 5.0 | 0 | 400 | 42 | 57 | 9.5 | 2 | ||
| 13 | | Bills | 514 | 10/24/2010 | @ | 132 | 35 | 3.8 | 0 | 382 | 29 | 43 | 13.2 | 4 | ||
| 14 | | Bills | 512 | 11/26/2023 | @ | 173 | 40 | 4.3 | 2 | 339 | 29 | 49 | 11.7 | 2 | ||
| 15 | | Bills | 510 | 9/13/1992 | @ | 107 | 33 | 3.2 | 1 | 403 | 22 | 18.3 | 3 | |||
| 16 | | Bills | 508 | 11/20/1966 | @ | 156 | 38 | 4.1 | 1 | 352 | 18 | 19.6 | 4 | |||
| 17 | | Bills | 508 | 9/18/1966 | vs | 179 | 34 | 5.3 | 4 | 329 | 17 | 19.4 | 2 | |||
| 18 | | Bills | 505 | 11/13/2022 | vs | 175 | 27 | 6.5 | 2 | 330 | 29 | 41 | 11.4 | 1 | ||
| 19 | | Bills | 505 | 11/14/2021 | @ | 139 | 24 | 5.8 | 4 | 366 | 21 | 28 | 17.4 | 2 | ||
| 20 | | Bills | 503 | 10/25/1987 | @ | 144 | 39 | 3.7 | 2 | 359 | 29 | 12.4 | 2 | |||
| 21 | | Bills | 502 | 9/7/2025 | vs | 108 | 31 | 3.5 | 3 | 394 | 33 | 45 | 11.9 | 2 | ||
| 22 | | Bills | 499 | 11/11/2012 | @ | 162 | 28 | 5.8 | 2 | 337 | 27 | 40 | 12.5 | 2 | ||
| 23 | | Bills | 497 | 9/24/2006 | vs | 169 | 31 | 5.5 | 1 | 328 | 22 | 37 | 14.9 | 1 | ||
| 24 | | Bills | 497 | 10/6/2002 | vs | 80 | 18 | 4.4 | 2 | 417 | 32 | 53 | 13.0 | 2 | ||
| 25 | | Bills | 495 | 10/9/1983 | @ | 76 | 23 | 3.3 | 0 | 419 | 38 | 11.0 | 5 | |||
NYJ
NYJMore NFL News
Khosla family agrees to purchase defending Super Bowl champion Seattle for $9.612B, AP source says
Bears sign third-round pick Sam Roush, a tight end from Stanford
Washington Commanders are retiring Hall of Famer John Riggins' No. 44 on Nov. 8
Adam Vinatieri will celebrate on the field in Indianapolis again as Colts' Ring of Honor member
Former Dallas Cowboys defensive end Kneeland had early stage CTE at time of death
Cornerback Rasul Douglas agrees to a 1-year contract with the Commanders, AP source says
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |