Since 2000, the Arizona Cardinals have their highest point differential in a game versus the 49ers on September 27, 2015, with a 40-point differential.
Interpreted as:
cardinals biggest win margin in a regular-season game since 2000| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cardinals | 40 | 9/27/2015 | vs | W 47-7 | 6 | 28 | 446 | 156 | 46.2 | 100.0 | ||
| 2 | | Cardinals | 38 | 1/1/2017 | @ | W 44-6 | 5 | 21 | 344 | 123 | 28.6 | 50.0 | ||
| 3 | | Cardinals | 33 | 9/18/2016 | vs | W 40-7 | 5 | 20 | 416 | 306 | 42.9 | |||
| 4 | | Cardinals | 31 | 9/15/2024 | vs | W 41-10 | 5 | 24 | 489 | 245 | 63.6 | |||
| 5 | | Cardinals | 30 | 12/27/2015 | vs | W 38-8 | 5 | 19 | 381 | 178 | 50.0 | |||
| 6 | | Cardinals | 30 | 12/12/2010 | vs | W 43-13 | 4 | 21 | 357 | 288 | 25.0 | 100.0 | ||
| 7 | | Cardinals | 29 | 11/24/2013 | vs | W 40-11 | 4 | 27 | 410 | 239 | 50.0 | |||
| 8 | | Cardinals | 29 | 12/30/2007 | vs | W 48-19 | 6 | 25 | 422 | 234 | 46.2 | 100.0 | ||
| 9 | | Cardinals | 28 | 10/19/2020 | @ | W 38-10 | 5 | 22 | 438 | 344 | 53.8 | 100.0 | ||
| 10 | | Cardinals | 28 | 12/16/2012 | vs | W 38-10 | 5 | 12 | 196 | 312 | 16.7 | |||
| 11 | | Cardinals | 26 | 10/24/2021 | vs | W 31-5 | 4 | 24 | 397 | 160 | 50.0 | 100.0 | ||
| 12 | | Cardinals | 25 | 11/10/2024 | vs | W 31-6 | 4 | 28 | 406 | 207 | 71.4 | 100.0 | ||
| 13 | | Cardinals | 25 | 9/12/2021 | @ | W 38-13 | 5 | 22 | 416 | 248 | 53.8 | |||
| 14 | | Cardinals | 25 | 10/17/2016 | vs | W 28-3 | 4 | 28 | 396 | 230 | 54.5 | |||
| 15 | | Cardinals | 25 | 10/11/2015 | @ | W 42-17 | 6 | 15 | 345 | 435 | 12.5 | |||
| 16 | | Cardinals | 25 | 9/20/2015 | @ | W 48-23 | 7 | 21 | 300 | 335 | 55.6 | 100.0 | ||
| 17 | | Cardinals | 24 | 12/6/2015 | @ | W 27-3 | 3 | 29 | 524 | 212 | 43.8 | 0.0 | ||
| 18 | | Cardinals | 24 | 10/18/2009 | @ | W 27-3 | 3 | 21 | 344 | 128 | 50.0 | |||
| 19 | | Cardinals | 24 | 12/7/2008 | vs | W 34-10 | 4 | 18 | 335 | 308 | 33.3 | |||
| 20 | | Cardinals | 24 | 10/5/2008 | vs | W 41-17 | 5 | 28 | 373 | 287 | 60.0 | 50.0 | ||
| 21 | | Cardinals | 24 | 12/19/2004 | vs | W 31-7 | 4 | 26 | 402 | 185 | 47.1 | 100.0 | ||
| 22 | | Cardinals | 24 | 10/3/2004 | vs | W 34-10 | 4 | 19 | 373 | 279 | 25.0 | 100.0 | ||
| 23 | | Cardinals | 23 | 1/5/2025 | vs | W 47-24 | 6 | 26 | 393 | 436 | 36.4 | 100.0 | ||
| 24 | | Cardinals | 23 | 10/17/2021 | @ | W 37-14 | 4 | 24 | 348 | 290 | 53.3 | 100.0 | ||
| 25 | | Cardinals | 23 | 12/24/2017 | vs | W 23-0 | 3 | 19 | 289 | 293 | 35.7 | |||
LA
NYJ
CHIMore Cardinals Stats
Team Leaders 
PASS
3,366
Brissett
RUSH
333
Carter
REC
1,239
McBride
Team Rankings
PPG
20.9
23rd
OPP PPG
28.7
29th
RUSH YDS/G
93.1
31st
PASS YDS/G
256.1
5th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
