The Arizona Cardinals have an 11-9 record against the spread against the 49ers in their last 20 games.

	TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	Cardinals	11/13/2016	0-1	ARI	-900	vs	SF	+625	W 23-20	-13.5	-10.5 (N)	46.5	-3.5 (U)	2	26	443	281	50.0
2	Cardinals	10/1/2017	0-1	ARI	-270	vs	SF	+230	W 18-15	-6.5	-3.5 (N)	43.5	-10.5 (U)	1	25	368	305	31.3
3	Cardinals	11/5/2017	1-0	ARI	-128	@	SF	+118	W 20-10	-2.5	+7.5 (Y)	39.5	-9.5 (U)	2	20	368	329	43.8
4	Cardinals	10/7/2018	1-0	ARI	+146	@	SF	-156	W 28-18	+3	+13 (Y)	40.5	+5.5 (O)	4	10	220	447	16.7
5	Cardinals	10/28/2018	1-0	ARI	+130	vs	SF	-140	W 18-15	+2.5	+5.5 (Y)	40	-7 (U)	2	20	321	267	42.9
6	Cardinals	10/31/2019	1-0	ARI	+389	vs	SF	-521	L 25-28	+10.5	+7.5 (Y)	43.5	+9.5 (O)	3	19	357	411	25.0
7	Cardinals	11/17/2019	0-1	ARI	+351	@	SF	-470	L 26-36	+9.5	-0.5 (N)	44	+18 (O)	3	21	266	442	30.0	100.0
8	Cardinals	9/13/2020	1-0	ARI	+245	@	SF	-312	W 24-20	+6.5	+10.5 (Y)	48	-4 (U)	3	29	404	366	50.0
9	Cardinals	12/26/2020	0-1	ARI	-266	vs	SF	+213	L 12-20	-6	-14 (N)	49	-17 (U)	1	20	350	398	25.0	66.7
10	Cardinals	10/10/2021	1-0	ARI	-257	vs	SF	+208	W 17-10	-5.5	+1.5 (Y)	48.5	-21.5 (U)	2	20	304	338	30.0
11	Cardinals	11/7/2021	1-0	ARI	+199	@	SF	-247	W 31-17	+5.5	+19.5 (Y)	44.5	+3.5 (O)	4	22	437	337	46.7	50.0
12	Cardinals	11/21/2022	0-1	ARI	+341	vs	SF	-442	L 10-38	+9.5	-18.5 (N)	43	+5 (O)	1	19	314	387	50.0	0.0
13	Cardinals	1/8/2023	0-1	ARI	+693	@	SF	-1057	L 13-38	+14.5	-10.5 (N)	39.5	+11.5 (O)	2	11	255	311	40.0	0.0
14	Cardinals	10/1/2023	0-1	ARI	+692	@	SF	-1106	L 16-35	+14.5	-4.5 (N)	44	+7 (O)	2	23	362	395	53.3	66.7
15	Cardinals	12/17/2023	0-1	ARI	+529	vs	SF	-771	L 29-45	+12.5	-3.5 (N)	48	+26 (O)	3	22	436	406	43.8	75.0
16	Cardinals	10/6/2024	1-0	ARI	+278	@	SF	-350	W 24-23	+7.5	+8.5 (Y)	48.5	-1.5 (U)	2	19	358	384	30.0	100.0
17	Cardinals	1/5/2025	1-0	ARI	-229	vs	SF	+188	W 47-24	-4.5	+18.5 (Y)	43	+28 (O)	6	26	393	436	36.4	100.0
18	Cardinals	9/21/2025	1-0	ARI	+103	@	SF	-123	L 15-16	+1.5	+0.5 (Y)	44.5	-13.5 (U)	1	16	260	355	33.3	100.0
19	Cardinals	11/16/2025	0-1	ARI	+158	vs	SF	-191	L 22-41	+3.5	-15.5 (N)	48.5	+14.5 (O)	3	24	488	281	42.9
20	Cardinals	9/27/2026	1-0	ARI	+308	@	SF	-394	L 30-36	+7.5	+1.5 (Y)	48.5	+17.5 (O)	3	27	365	437	50.0	100.0
	Average		2.8											2.5	21.0	353.5	365.7	39.6	0.1
	Total		11-9											50	419	7,069	7,313	39.6	66.7

StatMuse has team, game-level data for spread records going back to the 1979 season.

More NFL News

Huntley leads late TD drive to force OT and then scores on 1-yard run as Ravens beat Falcons 30-23

Oct 12, 2026

Falcons' Michael Penix Jr. sustains rib injury in 4th quarter in OT loss to Ravens

Oct 12, 2026

Falcons sacks king John Abraham has former coach Mike Smith return to lead ring of honor ceremony

Oct 12, 2026

Jaxon Smith-Njigba's drop and 4 turnovers hurt the Seahawks in their loss to the 49ers

Oct 12, 2026

Broncos' struggles on offense continue in Sean Payton's return to play-calling

Oct 12, 2026

Vikings defense remains dominant in New Orleans as Minnesota improves to 5-0

Oct 12, 2026

More Cardinals Stats

Team Leaders

PASS

1,110

Brissett

RUSH

245

Love

REC

308

McBride

Team Rankings

PPG

21.6

22nd

OPP PPG

32.4

32nd

RUSH YDS/G

91.6

23rd

PASS YDS/G

223.4

19th

2026 Division Standings

TEAM	W	L	PCT
49ers	5	0	1.000
Seahawks	3	2	.600
Rams	2	2	.500
Cardinals	1	4	.200

Schedule

DATE	MATCHUP			TIME (ET)
Sun 10/18	ARI	@	LAR	4:05 PM
Sun 10/25	DEN	@	ARI	4:05 PM
Sun 11/1	ARI	@	DAL	1:00 PM
Sun 11/8	ARI	@	SEA	4:25 PM
Sun 11/15	LAR	@	ARI	4:05 PM

Last Game

Lions

3 - 2

Final

Cardinals

1 - 4

Sun 11 Oct 2026

NFL 2026 Leaders

Pass Yards Leaders

1,485

Goff

1,408

Love

1,402

Stroud

Rush Yards Leaders

580

Robinson

537

Walker

504

Gibbs

Rec Yards Leaders

583

Smith-Njigba

537

Olave

507

Lamb

Pass TD Leaders

13

Purdy

12

Goff

12

Cousins

Rush TD Leaders

7

Gibbs

7

Allen

7

Henry

Rec TD Leaders

7

Smith-Njigba

6

Watson

5

St. Brown

QB Rating Leaders

119.6

Jackson

119.3

Purdy

111.3

Goff

Sack Leaders

7.5

Anderson

6.0

Rousseau

5.5

Turner

NFL 2026 Rankings

PPG Rankings

32.8

31.8

30.8

30.3

29.5

29.2

Opp PPG Rankings

12.8

14.0

18.6

18.8

19.2

Total Yards Rankings

417.0

412.0

405.8

394.2

393.8

392.4

Rush Yards Rankings

173.2

166.8

164.4

162.3

139.6

139.0

Pass Yards Rankings

317.0

300.5

297.0

281.6

280.4

276.2

Sack Leaders

20.0

18.0

17.0

16.0

NFL Fantasy 2026

Fantasy RB Rankings

126.7

Gibbs

103.8

Henry

103.2

Robinson

Fantasy WR Rankings

102.5

Smith-Njigba

83.4

Watson

76.1

Lamb

Fantasy TE Rankings

52.4

Likely

50.8

Kittle

49.6

LaPorta

Fantasy K Rankings

75

Shrader

68

Reichard

54

Loop

NFL 2026 Betting

Best Record ATS

4-1

3-1

3-1-1

Worst Record ATS

0-4-1

1-4

1-3-1

2-3

NFL 2026 Standings

NFC East	W	L	T	PCT
Giants	3	1	1	.700
Eagles	2	3	0	.400
Cowboys	2	3	0	.400
Commanders	1	3	1	.300
NFC North	W	L	T	PCT
Vikings	5	0	0	1.000
Packers	3	2	0	.600
Lions	3	2	0	.600
Bears	3	2	0	.600
NFC South	W	L	T	PCT
Panthers	2	2	0	.500
Falcons	2	3	0	.400
Buccaneers	1	4	0	.200
Saints	1	4	0	.200
NFC West	W	L	T	PCT
49ers	5	0	0	1.000
Seahawks	3	2	0	.600
Rams	2	2	0	.500
Cardinals	1	4	0	.200

AFC East	W	L	T	PCT
Bills	3	1	0	.750
Patriots	3	2	0	.600
Jets	2	3	0	.400
Dolphins	0	5	0	.000
AFC North	W	L	T	PCT
Ravens	4	1	0	.800
Browns	3	2	0	.600
Steelers	3	2	0	.600
Bengals	3	2	0	.600
AFC South	W	L	T	PCT
Jaguars	4	1	0	.800
Colts	2	3	0	.400
Texans	1	4	0	.200
Titans	0	5	0	.000
AFC West	W	L	T	PCT
Chiefs	4	0	0	1.000
Broncos	3	2	0	.600
Raiders	3	2	0	.600
Chargers	0	5	0	.000