The Indianapolis Colts have a record of 27-19 against the 49ers in the regular season and playoffs all-time.
| TEAM | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Colts | 11/29/1953 | vs | L 21-38 | 3 | 18 | 234 | 368 | ||||
| 2 | | Colts | 12/13/1953 | @ | L 14-45 | 2 | 12 | 136 | 597 | ||||
| 3 | | Colts | 11/28/1954 | vs | W 17-13 | 2 | 15 | 297 | 325 | ||||
| 4 | | Colts | 12/11/1954 | @ | L 7-10 | 1 | 17 | 273 | 292 | ||||
| 5 | | Colts | 11/27/1955 | vs | W 26-14 | 3 | 22 | 392 | 296 | ||||
| 6 | | Colts | 12/11/1955 | @ | L 24-35 | 3 | 20 | 327 | 325 | ||||
| 7 | | Colts | 12/2/1956 | vs | L 17-20 | 2 | 22 | 302 | 360 | ||||
| 8 | | Colts | 12/16/1956 | @ | L 17-30 | 2 | 22 | 336 | 303 | ||||
| 9 | | Colts | 11/24/1957 | vs | W 27-21 | 3 | 23 | 455 | 410 | ||||
| 10 | | Colts | 12/8/1957 | @ | L 13-17 | 2 | 16 | 370 | 326 | ||||
| 11 | | Colts | 11/30/1958 | vs | W 35-27 | 5 | 24 | 415 | 313 | ||||
| 12 | | Colts | 12/14/1958 | @ | L 12-21 | 1 | 13 | 289 | 368 | ||||
| 13 | | Colts | 11/22/1959 | vs | W 45-14 | 6 | 29 | 439 | 133 | ||||
| 14 | | Colts | 12/5/1959 | @ | W 34-14 | 5 | 25 | 395 | 254 | ||||
| 15 | | Colts | 11/27/1960 | vs | L 22-30 | 3 | 19 | 428 | 356 | ||||
| 16 | | Colts | 12/18/1960 | @ | L 10-34 | 1 | 9 | 177 | 251 | ||||
| 17 | | Colts | 12/3/1961 | vs | W 20-17 | 2 | 18 | 346 | 309 | ||||
| 18 | | Colts | 12/16/1961 | @ | W 27-24 | 3 | 21 | 366 | 355 | ||||
| 19 | | Colts | 10/7/1962 | vs | L 13-21 | 2 | 18 | 261 | 335 | ||||
| 20 | | Colts | 11/4/1962 | @ | W 22-3 | 2 | 15 | 311 | 151 | ||||
| 21 | | Colts | 9/22/1963 | @ | W 20-14 | 2 | 27 | 395 | 194 | ||||
| 22 | | Colts | 10/13/1963 | vs | W 20-3 | 2 | 18 | 302 | 120 | ||||
| 23 | | Colts | 11/1/1964 | vs | W 37-7 | 5 | 21 | 384 | 221 | ||||
| 24 | | Colts | 11/29/1964 | @ | W 14-3 | 2 | 16 | 239 | 246 | ||||
| 25 | | Colts | 10/3/1965 | vs | W 27-24 | 3 | 20 | 341 | 352 | ||||
| Average | 2.9 | 19.8 | 343.1 | 311.8 | |||||||||
| Total | 132 | 909 | 15,781 | 14,343 | |||||||||
BAL
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More Colts Stats
Team Leaders 
PASS
754
Jones
RUSH
353
Taylor
REC
202
Downs
Team Rankings
PPG
25.5
13th
OPP PPG
26.0
22nd
RUSH YDS/G
109.5
14th
PASS YDS/G
188.5
26th
Jaguars
Colts
Titans
Texans
PIT
MIN
DAL
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
| NFC North | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 4 | 0 | .000 | |
| NFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 |
Giants
Eagles
Commanders
Bears
Lions
Packers
Panthers
Saints
Falcons
Buccaneers
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| AFC South | W | L | T | PCT |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 | |
0 | 4 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 |
Bills
Patriots
Jets
Dolphins
Browns
Ravens
Bengals
Chiefs
Raiders
Broncos
Chargers