Drew Brees had his most passing yards in a game against the Bengals on November 19, 2006, with 510 yards.

Interpreted as:

Drew Brees highest passing yard regular-season game

	NAME	YDS	DATE	TM		OPP	CMP	ATT	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Drew Brees D. Brees	510	11/19/2006	NO	vs	CIN	37	52	71.2	9.8	2	3	91.0	3.8	5.8	2	6
2	Drew Brees D. Brees	505	11/1/2015	NO	vs	NYG	39	50	78.0	10.1	7	2	131.7	14.0	4.0	0	0
3	Drew Brees D. Brees	465	10/16/2016	NO	vs	CAR	34	49	69.4	9.5	4	1	118.2	8.2	2.0	1	5
4	Drew Brees D. Brees	446	12/23/2012	NO	@	DAL	37	53	69.8	8.4	3	0	114.2	5.7	0.0	0	0
5	Drew Brees D. Brees	446	9/30/2012	NO	@	GB	35	54	64.8	8.3	3	0	109.0	5.6	0.0	2	17
6	Drew Brees D. Brees	445	11/4/2007	NO	vs	JAX	35	49	71.4	9.1	3	0	119.9	6.1	0.0	1	10
7	Drew Brees D. Brees	439	9/9/2018	NO	vs	TB	37	45	82.2	9.8	3	0	129.5	6.7	0.0	1	7
8	Drew Brees D. Brees	423	9/11/2016	NO	vs	OAK	28	42	66.7	10.1	4	0	131.3	9.5	0.0	1	4
9	Drew Brees D. Brees	422	11/9/2008	NO	@	ATL	31	58	53.4	7.3	2	3	66.9	3.4	5.2	1	6
10	Drew Brees D. Brees	421	9/21/2008	NO	@	DEN	39	48	81.3	8.8	1	0	110.2	2.1	0.0	1	7
11	Drew Brees D. Brees	420	11/24/2014	NO	vs	BAL	35	45	77.8	9.3	3	1	118.5	6.7	2.2	4	21
12	Drew Brees D. Brees	419	9/8/2011	NO	@	GB	32	49	65.3	8.6	3	0	112.5	6.1	0.0	3	23
13	Drew Brees D. Brees	419	12/6/2009	NO	@	WAS	35	49	71.4	8.6	2	1	102.3	4.1	2.0	1	11
14	Drew Brees D. Brees	413	9/30/2013	NO	vs	MIA	30	39	76.9	10.6	4	0	144.5	10.3	0.0	2	16
15	Drew Brees D. Brees	412	12/27/2015	NO	vs	JAX	25	36	69.4	11.4	3	0	135.4	8.3	0.0	1	10
16	Drew Brees D. Brees	412	12/18/2011	NO	@	MIN	32	40	80.0	10.3	5	0	149.2	12.5	0.0	0	0
17	Drew Brees D. Brees	398	11/12/2006	NO	@	PIT	31	47	66.0	8.5	1	0	99.4	2.1	0.0	1	5
18	Drew Brees D. Brees	396	9/23/2018	NO	@	ATL	39	49	79.6	8.1	3	0	120.7	6.1	0.0	1	5
19	Drew Brees D. Brees	396	12/30/2012	NO	vs	CAR	29	43	67.4	9.2	4	1	118.0	9.3	2.3	2	18
20	Drew Brees D. Brees	393	12/15/2013	NO	@	STL	39	56	69.6	7.0	1	2	80.4	1.8	3.6	4	22
21	Drew Brees D. Brees	392	11/10/2013	NO	vs	DAL	34	41	82.9	9.6	4	0	139.0	9.8	0.0	1	9
22	Drew Brees D. Brees	389	12/18/2016	NO	@	ARI	37	48	77.1	8.1	4	0	127.9	8.3	0.0	3	31
23	Drew Brees D. Brees	389	1/1/2012	NO	vs	CAR	28	35	80.0	11.1	5	1	140.7	14.3	2.9	0	0
24	Drew Brees D. Brees	387	11/8/2015	NO	vs	TEN	28	39	71.8	9.9	3	1	118.2	7.7	2.6	4	32
25	Drew Brees D. Brees	386	12/28/2008	NO	vs	CAR	30	49	61.2	7.9	4	1	104.6	8.2	2.0	2	19

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Results may be incomplete. StatMuse has complete game-level data for passing yards going back to the 1950 season.

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DATE	MATCHUP			TIME (ET)
Sun 12/28	NO	@	TEN	1:00 PM
Sun 1/4	NO	@	ATL	1:00 PM

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Patriots - x	12	3	0	.800
Bills - x	11	4	0	.733
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Jets - e	3	12	0	.200
AFC North	W	L	T	PCT
Steelers	9	6	0	.600
Ravens	7	8	0	.467
Bengals - e	5	10	0	.333
Browns - e	3	12	0	.200
AFC South	W	L	T	PCT
Jaguars - x	11	4	0	.733
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Titans - e	3	12	0	.200
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Falcons - e	6	9	0	.400
Saints - e	5	10	0	.333
NFC West	W	L	T	PCT
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DATE	MATCHUP			SCORE
Sat 9/20	NO	@	SEA	13-44
Sat 9/20	ARI	@	SF	15-16
Sat 9/20	DAL	@	CHI	14-31
Sat 9/20	KC	@	NYG	22-9
Sun 9/21	DET	@	BAL	38-30

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DATE	MATCHUP			TIME (ET)
Sat 12/27	BAL	@	GB	8:00 PM
Sun 12/28	TB	@	MIA	1:00 PM
Sun 12/28	NE	@	NYJ	1:00 PM
Sun 12/28	PIT	@	CLE	1:00 PM
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Drew Brees had his most passing yards in a game against the Bengals on November 19, 2006, with 510 yards.

Interpreted as:

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