Drew Brees had his most passing yards per completion in a game against the Browns on December 19, 2004, with 21.25.

Interpreted as:

Drew Brees highest passing yards per completion in a regular-season game

	NAME	YDS/CMP	YDS	CMP	DATE	TM		OPP	ATT	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Drew Brees D. Brees	21.25	85	4	12/19/2004	SD	@	CLE	6	66.7	14.2	1	0	149.3	16.7	0.0	1	2
2	Drew Brees D. Brees	20.61	371	18	11/30/2009	NO	vs	NE	23	78.3	16.1	5	0	158.3	21.7	0.0	1	4
3	Drew Brees D. Brees	18.25	146	8	9/19/2004	SD	vs	NYJ	19	42.1	7.7	1	2	47.1	5.3	10.5	1	7
4	Drew Brees D. Brees	16.62	349	21	11/26/2006	NO	@	ATL	30	70.0	11.6	2	0	131.1	6.7	0.0	2	17
5	Drew Brees D. Brees	16.5	363	22	11/18/2018	NO	vs	PHI	30	73.3	12.1	4	0	153.2	13.3	0.0	0	0
6	Drew Brees D. Brees	16.48	412	25	12/27/2015	NO	vs	JAX	36	69.4	11.4	3	0	135.4	8.3	0.0	1	10
7	Drew Brees D. Brees	16.37	311	19	12/25/2020	NO	vs	MIN	26	73.1	12.0	0	2	80.8	0.0	7.7	0	0
8	Drew Brees D. Brees	16.15	323	20	11/24/2008	NO	vs	GB	26	76.9	12.4	4	0	157.5	15.4	0.0	1	5
9	Drew Brees D. Brees	16.04	369	23	10/18/2009	NO	vs	NYG	30	76.7	12.3	4	0	156.8	13.3	0.0	0	0
10	Drew Brees D. Brees	15.96	383	24	10/29/2006	NO	vs	BAL	45	53.3	8.5	3	3	76.4	6.7	6.7	2	15
11	Drew Brees D. Brees	15.88	381	24	12/29/2013	NO	vs	TB	31	77.4	12.3	4	0	157.4	12.9	0.0	1	11
12	Drew Brees D. Brees	15.78	363	23	9/28/2008	NO	vs	SF	35	65.7	10.4	3	1	116.7	8.6	2.9	0	0
13	Drew Brees D. Brees	15.6	234	15	12/20/2020	NO	vs	KC	34	44.1	6.9	3	1	84.7	8.8	2.9	1	9
14	Drew Brees D. Brees	15.3	352	23	11/25/2010	NO	@	DAL	39	59.0	9.0	1	1	86.7	2.6	2.6	2	19
15	Drew Brees D. Brees	15.13	363	24	11/28/2011	NO	vs	NYG	38	63.2	9.6	4	0	129.6	10.5	0.0	0	0
16	Drew Brees D. Brees	15.11	423	28	9/11/2016	NO	vs	OAK	42	66.7	10.1	4	0	131.3	9.5	0.0	1	4
17	Drew Brees D. Brees	14.91	343	23	9/7/2008	NO	vs	TB	32	71.9	10.7	3	1	124.9	9.4	3.1	1	6
18	Drew Brees D. Brees	14.77	384	26	12/10/2006	NO	@	DAL	38	68.4	10.1	5	0	140.8	13.2	0.0	1	7
19	Drew Brees D. Brees	14.73	221	15	11/4/2001	SD	vs	KC	27	55.6	8.2	1	0	94.8	3.7	0.0	2	12
20	Drew Brees D. Brees	14.43	303	21	11/13/2016	NO	vs	DEN	29	72.4	10.4	3	2	111.7	10.3	6.9	1	10
21	Drew Brees D. Brees	14.19	298	21	11/11/2012	NO	vs	ATL	32	65.6	9.3	3	1	113.8	9.4	3.1	1	6
22	Drew Brees D. Brees	14.13	339	24	9/9/2012	NO	vs	WAS	52	46.2	6.5	3	2	70.9	5.8	3.8	2	13
23	Drew Brees D. Brees	13.96	377	27	10/21/2012	NO	@	TB	37	73.0	10.2	4	1	130.1	10.8	2.7	0	0
24	Drew Brees D. Brees	13.96	363	26	10/8/2018	NO	vs	WAS	29	89.7	12.5	3	0	153.2	10.3	0.0	2	14
25	Drew Brees D. Brees	13.89	389	28	1/1/2012	NO	vs	CAR	35	80.0	11.1	5	1	140.7	14.3	2.9	0	0

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Results may be incomplete. StatMuse has complete game-level data for completions and passing yards going back to the 1950 season.

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Sat 9/27	LAC	@	NYG	18-21
Sat 9/27	JAX	@	SF	26-21
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Drew Brees had his most passing yards per completion in a game against the Browns on December 19, 2004, with 21.25.

Interpreted as:

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