James Cook III had his most rushing yards in a game against the Panthers on October 26, 2025, with 216 yards.
| NAME | RUSH YDS | DATE | TM | OPP | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 216 | 10/26/2025 | @ | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |||
| 2 | | J. Cook III | 179 | 12/17/2023 | vs | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 | ||
| 3 | | J. Cook III | 154 | 9/27/2026 | vs | 24 | 6.4 | 1 | 0 | 0 | 1 | 0 | |||
| 4 | | J. Cook III | 144 | 11/30/2025 | @ | 32 | 4.5 | 0 | 33 | 3 | 3 | 11.0 | 0 | ||
| 5 | | J. Cook III | 135 | 9/17/2026 | vs | 21 | 6.4 | 1 | 4 | 1 | 3 | 4.0 | 0 | ||
| 6 | | J. Cook III | 132 | 9/14/2025 | @ | 21 | 6.3 | 2 | 3 | 1 | 1 | 3.0 | 0 | ||
| 7 | | J. Cook III | 123 | 9/17/2023 | vs | 17 | 7.2 | 0 | 36 | 4 | 4 | 9.0 | 0 | ||
| 8 | | J. Cook III | 117 | 12/21/2025 | @ | 16 | 7.3 | 2 | 17 | 1 | 2 | 17.0 | 0 | ||
| 9 | | J. Cook III | 117 | 9/28/2025 | vs | 22 | 5.3 | 1 | 18 | 3 | 4 | 6.0 | 0 | ||
| 10 | | J. Cook III | 116 | 11/20/2025 | @ | 17 | 6.8 | 1 | 13 | 3 | 3 | 4.3 | 0 | ||
| 11 | | J. Cook III | 114 | 11/2/2025 | vs | 27 | 4.2 | 0 | 11 | 1 | 1 | 11.0 | 0 | ||
| 12 | | J. Cook III | 111 | 10/27/2024 | @ | 17 | 6.5 | 2 | 22 | 3 | 3 | 7.3 | 0 | ||
| 13 | | J. Cook III | 109 | 11/13/2023 | vs | 12 | 9.1 | 0 | 11 | 2 | 2 | 5.5 | 0 | ||
| 14 | | J. Cook III | 108 | 9/18/2025 | vs | 19 | 5.7 | 1 | 10 | 3 | 3 | 3.3 | 0 | ||
| 15 | | J. Cook III | 107 | 12/14/2025 | @ | 22 | 4.9 | 2 | 4 | 2 | 3 | 2.0 | 1 | ||
| 16 | | J. Cook III | 107 | 12/1/2024 | vs | 14 | 7.6 | 1 | 13 | 1 | 1 | 13.0 | 0 | ||
| 17 | | J. Cook III | 105 | 12/15/2024 | @ | 14 | 7.5 | 2 | 28 | 1 | 1 | 28.0 | 0 | ||
| 18 | | J. Cook III | 100 | 12/22/2024 | vs | 11 | 9.1 | 1 | 26 | 3 | 3 | 8.7 | 1 | ||
| 19 | | J. Cook III | 99 | 12/24/2022 | @ | 11 | 9.0 | 1 | 9 | 1 | 2 | 9.0 | 0 | ||
| 20 | | J. Cook III | 98 | 9/24/2023 | @ | 15 | 6.5 | 0 | 14 | 2 | 3 | 7.0 | 0 | ||
| 21 | | J. Cook III | 87 | 10/13/2025 | @ | 17 | 5.1 | 0 | 0 | 0 | 0 | 0 | |||
| 22 | | J. Cook III | 86 | 11/20/2022 | vs | 11 | 7.8 | 0 | 0 | 0 | 1 | 0 | |||
| 23 | | J. Cook III | 82 | 10/6/2024 | @ | 20 | 4.1 | 1 | 17 | 2 | 3 | 8.5 | 0 | ||
| 24 | | J. Cook III | 80 | 12/7/2025 | vs | 18 | 4.4 | 0 | 31 | 2 | 2 | 15.5 | 0 | ||
| 25 | | J. Cook III | 80 | 11/10/2024 | @ | 19 | 4.2 | 1 | 5 | 1 | 3 | 5.0 | 0 | ||
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INDResults may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.
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More Bills Stats
Team Leaders 
PASS
1,039
Allen
RUSH
421
Cook
REC
270
Kincaid
Team Rankings
PPG
31.8
2nd
OPP PPG
26.8
25th
RUSH YDS/G
139.0
6th
PASS YDS/G
259.8
10th
LAR
BAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Packers
Bears
Buccaneers
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
Jaguars
Titans