James Cook III, James Conner and Edgerrin James were tied for their most points in a game, with 18 points.

Interpreted as:

le ron james highest points in a regular-season game

	NAME	PTS	DATE	TM		OPP	RUSH YDS	ATT	YPC	RUSH TD	REC YDS	REC	TRG	AVG	REC TD
1	James Cook III J. Cook III	18	12/14/2025	BUF	@	NE	107	22	4.9	2	4	2	3	2.0	1
2	James Cook III J. Cook III	18	9/12/2024	BUF	@	MIA	78	11	7.1	2	17	1	1	17.0	1
3	James Conner J. Conner	18	11/7/2021	ARI	@	SF	96	21	4.6	2	77	5	5	15.4	1
4	Edgerrin James E. James	18	10/17/2005	IND	vs	STL	143	23	6.2	3	16	3	4	5.3	0
5	Edgerrin James E. James	18	11/16/2003	IND	vs	NYJ	127	36	3.5	3	33	6	7	5.5	0
6	Edgerrin James E. James	18	12/11/2000	IND	vs	BUF	111	27	4.1	3	21	3	4	7.0	0
7	Edgerrin James E. James	18	10/15/2000	IND	@	SEA	219	38	5.8	3	9	1	1	9.0	0
8	Edgerrin James E. James	18	12/26/1999	IND	@	CLE	103	28	3.7	3	18	3	4	6.0	0
9	Edgerrin James E. James	18	11/21/1999	IND	@	PHI	152	22	6.9	2	47	5	6	9.4	1
10	James Robinson J. Robinson	14	10/25/2020	JAX	@	LAC	119	22	5.4	1	18	4	6	4.5	1
11	Edgerrin James E. James	14	9/28/2008	ARI	@	NYJ	29	9	3.2	2	37	5	6	7.4	0
12	James Cook III J. Cook III	12	12/21/2025	BUF	@	CLE	117	16	7.3	2	17	1	2	17.0	0
13	James Cook III J. Cook III	12	10/26/2025	BUF	@	CAR	216	19	11.4	2	0	0	0		0
14	James Cook III J. Cook III	12	9/14/2025	BUF	@	NYJ	132	21	6.3	2	3	1	1	3.0	0
15	James Cook III J. Cook III	12	12/22/2024	BUF	vs	NE	100	11	9.1	1	26	3	3	8.7	1
16	James Conner J. Conner	12	12/15/2024	ARI	vs	NE	110	16	6.9	2	28	5	5	5.6	0
17	James Cook III J. Cook III	12	12/15/2024	BUF	@	DET	105	14	7.5	2	28	1	1	28.0	0
18	James Cook III J. Cook III	12	11/17/2024	BUF	vs	KC	20	9	2.2	2	7	5	6	1.4	0
19	James Cook III J. Cook III	12	10/27/2024	BUF	@	SEA	111	17	6.5	2	22	3	3	7.3	0
20	James Conner J. Conner	12	12/31/2023	ARI	@	PHI	128	26	4.9	1	5	1	1	5.0	1
21	James Cook III J. Cook III	12	12/17/2023	BUF	vs	DAL	179	25	7.2	1	42	2	3	21.0	1
22	James Conner J. Conner	12	12/3/2023	ARI	@	PIT	105	25	4.2	2	0	0	2		0
23	James Conner J. Conner	12	11/13/2022	ARI	@	LAR	69	21	3.3	2	17	3	3	5.7	0
24	James Robinson J. Robinson	12	9/11/2022	JAX	@	WAS	66	11	6.0	1	3	1	2	3.0	1
25	James Conner J. Conner	12	1/9/2022	ARI	vs	SEA	52	15	3.5	1	41	6	6	6.8	1

Unlock 2x data

Results may be incomplete. StatMuse has complete game-level data for points going back to the 1960 season.

More Bills Stats

Team Leaders

PASS

3,668

Allen

RUSH

1,621

Cook

REC

719

Shakir

Team Rankings

PPG

28.3

4th

OPP PPG

21.5

12th

RUSH YDS/G

159.6

1st

PASS YDS/G

234.2

13th

2025 Division Standings

TEAM	W	L	PCT
Patriots	14	3	.824
Bills	12	5	.706
Dolphins	7	10	.412
Jets	3	14	.176

Last Game

Bills

1 - 1

Final

Broncos

1 - 0

Sat 17 Jan 2026

NFL 2025 Leaders

Pass Yards Leaders

4,707

Stafford

4,564

Goff

4,552

Prescott

Rush Yards Leaders

1,621

Cook

1,595

Henry

1,585

Taylor

Rec Yards Leaders

1,793

Smith-Njigba

1,715

Nacua

1,429

Pickens

Pass TD Leaders

46

Stafford

34

Goff

31

Maye

Rush TD Leaders

18

Taylor

16

Henry

14

Allen

Rec TD Leaders

14

Adams

11

McBride

11

St. Brown

QB Rating Leaders

113.5

Maye

109.2

Stafford

105.5

Goff

Sack Leaders

23.0

Garrett

16.5

Burns

15.0

Hunter

NFL 2025 Rankings

PPG Rankings

30.5

28.8

28.4

28.3

27.9

Opp PPG Rankings

17.2

17.4

18.3

18.8

19.1

19.3

Total Yards Rankings

394.6

391.9

379.4

376.3

373.2

369.5

Rush Yards Rankings

159.6

156.6

144.5

134.7

129.1

128.9

Pass Yards Rankings

278.5

276.9

268.6

262.3

256.1

254.0

Sack Leaders

68.0

57.0

53.0

49.0

48.0

NFL Fantasy 2025

Fantasy RB Rankings

316.3

Taylor

314.6

McCaffrey

291.8

Robinson

Fantasy WR Rankings

246

Nacua

240.9

Smith-Njigba

207

St. Brown

Fantasy TE Rankings

189.9

McBride

125.1

Goedert

122.8

Pitts

Fantasy K Rankings

202

Myers

194

Fairbairn

187.6

Aubrey

NFL 2025 Betting

Best Record ATS

15-5

12-6

14-7

12-6-1

12-7

11-7

Worst Record ATS

5-12

5-12-1

6-11

7-10

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
NFC South	W	L	T	PCT
Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176