4 players were tied for their most points in a game, with 18 points. The first three are James Cook III on December 14 and on September 12, 2024, James Conner on November 7, 2021 and Le'Veon Bell on December 10, 2017, on December 11, 2016 and on December 7, 2014.
Interpreted as:
leveon james career high points in a single regular-season game vs every team| NAME | PTS | DATE | TM | OPP | RUSH YDS | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Cook III | 18 | 12/14/2025 | @ | 107 | 22 | 4.9 | 2 | 4 | 2 | 3 | 2.0 | 1 | ||
| 2 | | J. Cook III | 18 | 9/12/2024 | @ | 78 | 11 | 7.1 | 2 | 17 | 1 | 1 | 17.0 | 1 | ||
| 3 |  | J. Conner | 18 | 11/7/2021 | @ | 96 | 21 | 4.6 | 2 | 77 | 5 | 5 | 15.4 | 1 | ||
| 4 |  | L. Bell | 18 | 12/10/2017 | vs | 48 | 13 | 3.7 | 2 | 77 | 9 | 10 | 8.6 | 1 | ||
| 5 | | L. Bell | 18 | 12/11/2016 | @ | 236 | 38 | 6.2 | 3 | 62 | 4 | 5 | 15.5 | 0 | ||
| 6 | | L. Bell | 18 | 12/7/2014 | @ | 185 | 26 | 7.1 | 2 | 50 | 6 | 9 | 8.3 | 1 | ||
| 7 |  | E. James | 18 | 10/17/2005 | vs | 143 | 23 | 6.2 | 3 | 16 | 3 | 4 | 5.3 | 0 | ||
| 8 | | E. James | 18 | 11/16/2003 | vs | 127 | 36 | 3.5 | 3 | 33 | 6 | 7 | 5.5 | 0 | ||
| 9 | | E. James | 18 | 12/11/2000 | vs | 111 | 27 | 4.1 | 3 | 21 | 3 | 4 | 7.0 | 0 | ||
| 10 | | E. James | 18 | 10/15/2000 | @ | 219 | 38 | 5.8 | 3 | 9 | 1 | 1 | 9.0 | 0 | ||
| 11 | | E. James | 18 | 12/26/1999 | @ | 103 | 28 | 3.7 | 3 | 18 | 3 | 4 | 6.0 | 0 | ||
| 12 | | E. James | 18 | 11/21/1999 | @ | 152 | 22 | 6.9 | 2 | 47 | 5 | 6 | 9.4 | 1 | ||
| 13 |  | J. Robinson | 14 | 10/25/2020 | @ | 119 | 22 | 5.4 | 1 | 18 | 4 | 6 | 4.5 | 1 | ||
| 14 |  | E. James | 14 | 9/28/2008 | @ | 29 | 9 | 3.2 | 2 | 37 | 5 | 6 | 7.4 | 0 | ||
| 15 | | J. Cook III | 12 | 12/21/2025 | @ | 117 | 16 | 7.3 | 2 | 17 | 1 | 2 | 17.0 | 0 | ||
| 16 | | J. Cook III | 12 | 10/26/2025 | @ | 216 | 19 | 11.4 | 2 | 0 | 0 | 0 | 0 | |||
| 17 | | J. Cook III | 12 | 9/14/2025 | @ | 132 | 21 | 6.3 | 2 | 3 | 1 | 1 | 3.0 | 0 | ||
| 18 | | J. Cook III | 12 | 12/22/2024 | vs | 100 | 11 | 9.1 | 1 | 26 | 3 | 3 | 8.7 | 1 | ||
| 19 | | J. Conner | 12 | 12/15/2024 | vs | 110 | 16 | 6.9 | 2 | 28 | 5 | 5 | 5.6 | 0 | ||
| 20 | | J. Cook III | 12 | 12/15/2024 | @ | 105 | 14 | 7.5 | 2 | 28 | 1 | 1 | 28.0 | 0 | ||
| 21 | | J. Cook III | 12 | 11/17/2024 | vs | 20 | 9 | 2.2 | 2 | 7 | 5 | 6 | 1.4 | 0 | ||
| 22 | | J. Cook III | 12 | 10/27/2024 | @ | 111 | 17 | 6.5 | 2 | 22 | 3 | 3 | 7.3 | 0 | ||
| 23 | | J. Conner | 12 | 12/31/2023 | @ | 128 | 26 | 4.9 | 1 | 5 | 1 | 1 | 5.0 | 1 | ||
| 24 | | J. Cook III | 12 | 12/17/2023 | vs | 179 | 25 | 7.2 | 1 | 42 | 2 | 3 | 21.0 | 1 | ||
| 25 | | J. Conner | 12 | 12/3/2023 | @ | 105 | 25 | 4.2 | 2 | 0 | 0 | 2 | 0 | |||
BUF
PIT
BAL
IND
STL
NYJ
JAX
LAC
CAR
DETResults may be incomplete. StatMuse has complete game-level data for points going back to the 1960 season.
More Bills Stats
Team Leaders 
PASS
3,406
Allen
RUSH
1,532
Cook
REC
684
Shakir
Team Rankings
PPG
28.9
4th
OPP PPG
22.9
16th
RUSH YDS/G
158.9
1st
PASS YDS/G
230.7
16th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - x | 12 | 3 | 0 | .800 |
11 | 4 | 0 | .733 | |
 Dolphins - e | 6 | 9 | 0 | .400 |
 Jets - e | 3 | 12 | 0 | .200 |
| AFC North | W | L | T | PCT |
9 | 6 | 0 | .600 | |
7 | 8 | 0 | .467 | |
 Bengals - e | 5 | 10 | 0 | .333 |
 Browns - e | 3 | 12 | 0 | .200 |
| AFC South | W | L | T | PCT |
11 | 4 | 0 | .733 | |
10 | 5 | 0 | .667 | |
8 | 6 | 0 | .571 | |
 Titans - e | 3 | 12 | 0 | .200 |
| AFC West | W | L | T | PCT |
 Broncos - x | 12 | 3 | 0 | .800 |
11 | 4 | 0 | .733 | |
 Chiefs - e | 6 | 9 | 0 | .400 |
 Raiders - e | 2 | 13 | 0 | .133 |
Texans| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 10 | 5 | 0 | .667 |
 Cowboys - e | 6 | 8 | 1 | .433 |
 Commanders - e | 4 | 11 | 0 | .267 |
 Giants - e | 2 | 13 | 0 | .133 |
| NFC North | W | L | T | PCT |
 Bears - x | 11 | 4 | 0 | .733 |
9 | 5 | 1 | .633 | |
8 | 7 | 0 | .533 | |
 Vikings - e | 7 | 8 | 0 | .467 |
| NFC South | W | L | T | PCT |
8 | 7 | 0 | .533 | |
7 | 8 | 0 | .467 | |
 Falcons - e | 6 | 9 | 0 | .400 |
 Saints - e | 5 | 10 | 0 | .333 |
| NFC West | W | L | T | PCT |
 Seahawks - x | 12 | 3 | 0 | .800 |
 Rams - x | 11 | 4 | 0 | .733 |
 49ers - x | 10 | 4 | 0 | .714 |
 Cardinals - e | 3 | 12 | 0 | .200 |
Packers
Buccaneers
