Patrick Mahomes had his most passing touchdowns in a game on November 19, 2018 and on September 16, 2018, with 6 touchdowns.

Interpreted as:

mahomes most passing tds in a game regular season

	NAME	TD	DATE	TM		OPP	CMP	ATT	PCT	YDS	AVG	INT	RTG	TD%	INT%	SCK	SCKY
1	Patrick Mahomes P. Mahomes	6	11/19/2018	KC	@	LAR	33	46	71.7	478	10.4	3	117.6	13.0	6.5	3	30
2	Patrick Mahomes P. Mahomes	6	9/16/2018	KC	@	PIT	23	28	82.1	326	11.6	0	154.8	21.4	0.0	1	4
3	Patrick Mahomes P. Mahomes	5	9/11/2022	KC	@	ARI	30	39	76.9	360	9.2	0	144.2	12.8	0.0	0	0
4	Patrick Mahomes P. Mahomes	5	11/14/2021	KC	@	LV	35	50	70.0	406	8.1	0	127.6	10.0	0.0	0	0
5	Patrick Mahomes P. Mahomes	5	10/3/2021	KC	@	PHI	24	30	80.0	278	9.3	1	131.0	16.7	3.3	1	7
6	Patrick Mahomes P. Mahomes	5	11/1/2020	KC	vs	NYJ	31	42	73.8	416	9.9	0	144.4	11.9	0.0	0	0
7	Patrick Mahomes P. Mahomes	4	11/27/2025	KC	@	DAL	23	34	67.6	261	7.7	0	129.7	11.8	0.0	3	18
8	Patrick Mahomes P. Mahomes	4	9/28/2025	KC	vs	BAL	25	37	67.6	270	7.3	0	124.8	10.8	0.0	1	6
9	Patrick Mahomes P. Mahomes	4	10/22/2023	KC	vs	LAC	32	42	76.2	424	10.1	1	129.5	9.5	2.4	1	9
10	Patrick Mahomes P. Mahomes	4	11/13/2022	KC	vs	JAX	26	35	74.3	331	9.5	1	129.6	11.4	2.9	0	0
11	Patrick Mahomes P. Mahomes	4	10/10/2022	KC	vs	LV	29	43	67.4	292	6.8	0	117.6	9.3	0.0	3	27
12	Patrick Mahomes P. Mahomes	4	11/8/2020	KC	vs	CAR	30	45	66.7	372	8.3	0	121.7	8.9	0.0	2	11
13	Patrick Mahomes P. Mahomes	4	9/28/2020	KC	@	BAL	31	42	73.8	385	9.2	0	133.5	9.5	0.0	0	0
14	Patrick Mahomes P. Mahomes	4	9/15/2019	KC	@	OAK	30	44	68.2	443	10.1	0	131.2	9.1	0.0	2	7
15	Patrick Mahomes P. Mahomes	4	12/2/2018	KC	@	OAK	23	38	60.5	295	7.8	0	120.0	10.5	0.0	0	0
16	Patrick Mahomes P. Mahomes	4	10/28/2018	KC	vs	DEN	24	34	70.6	303	8.9	1	125.0	11.8	2.9	2	12
17	Patrick Mahomes P. Mahomes	4	10/21/2018	KC	vs	CIN	28	39	71.8	358	9.2	1	123.7	10.3	2.6	2	5
18	Patrick Mahomes P. Mahomes	4	10/14/2018	KC	@	NE	23	36	63.9	352	9.8	2	110.0	11.1	5.6	0	0
19	Patrick Mahomes P. Mahomes	4	9/9/2018	KC	@	LAC	15	27	55.6	256	9.5	0	127.5	14.8	0.0	1	0
20	Patrick Mahomes P. Mahomes	3	10/27/2025	KC	vs	WAS	25	34	73.5	299	8.8	2	104.9	8.8	5.9	3	15
21	Patrick Mahomes P. Mahomes	3	10/19/2025	KC	vs	LV	26	35	74.3	286	8.2	0	126.6	8.6	0.0	1	4
22	Patrick Mahomes P. Mahomes	3	10/12/2025	KC	vs	DET	22	30	73.3	257	8.6	0	132.2	10.0	0.0	3	14
23	Patrick Mahomes P. Mahomes	3	12/25/2024	KC	@	PIT	29	38	76.3	320	8.4	0	127.1	7.9	0.0	0	0
24	Patrick Mahomes P. Mahomes	3	11/24/2024	KC	@	CAR	27	37	73.0	269	7.3	0	120.2	8.1	0.0	5	43
25	Patrick Mahomes P. Mahomes	3	11/17/2024	KC	@	BUF	23	33	69.7	196	5.9	2	90.0	9.1	6.1	2	15

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Results may be incomplete. StatMuse has complete game-level data for passing touchdowns going back to the 1950 season.

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AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
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Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
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Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
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Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

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Cowboys - e	7	9	1	.441
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Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
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