Ben Roethlisberger had the most games with 450+ passing yards, with 6 games.

Interpreted as:

most 450 or more passing yards regular-season games by a player

	NAME	GP	YDS	CMP	ATT	PCT	AVG	YDS/G	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Ben Roethlisberger B. Roethlisberger	6	2,901	229	332	69.0	8.7	483.5	16	4	107.0	4.8	1.2	13	83
2	Dak Prescott D. Prescott	5	2,342	181	260	69.6	9.0	468.4	13	8	101.5	5.0	3.1	12	80
3	Dan Marino D. Marino	4	1,914	126	207	60.9	9.2	478.5	14	9	95.8	6.8	4.3	6	61
4	Jameis Winston J. Winston	3	1,411	95	145	65.5	9.7	470.3	12	7	104.7	8.3	4.8	6	41
5	Jared Goff J. Goff	3	1,476	109	160	68.1	9.2	492.0	12	3	114.5	7.5	1.9	6	57
6	Kirk Cousins K. Cousins	3	1,427	114	168	67.9	8.5	475.7	10	4	103.9	6.0	2.4	12	78
7	Matthew Stafford M. Stafford	3	1,465	98	156	62.8	9.4	488.3	9	4	102.1	5.8	2.6	3	26
8	Matt Schaub M. Schaub	3	1,484	120	159	75.5	9.3	494.7	9	4	112.3	5.7	2.5	9	71
9	Drew Brees D. Brees	3	1,480	110	151	72.8	9.8	493.3	13	6	115.8	8.6	4.0	3	11
10	Peyton Manning P. Manning	3	1,413	83	133	62.4	10.6	471.0	16	3	128.5	12.0	2.3	4	20
11	Tua Tagovailoa T. Tagovailoa	2	935	64	95	67.4	9.8	467.5	9	3	117.7	9.5	3.2	1	8
12	Joe Burrow J. Burrow	2	1,006	71	88	80.7	11.4	503.0	7	0	140.8	8.0	0.0	6	49
13	Patrick Mahomes P. Mahomes	2	940	70	95	73.7	9.9	470.0	9	3	123.1	9.5	3.2	5	36
14	Russell Wilson R. Wilson	2	902	56	82	68.3	11.0	451.0	7	2	123.1	8.5	2.4	5	34
15	Matt Ryan M. Ryan	2	953	65	91	71.4	10.5	476.5	6	2	118.1	6.6	2.2	5	38
16	Eli Manning E. Manning	2	960	58	93	62.4	10.3	480.0	7	6	95.3	7.5	6.5	3	22
17	Tom Brady T. Brady	2	983	70	107	65.4	9.2	491.5	7	1	112.8	6.5	0.9	3	16
18	Philip Rivers P. Rivers	2	958	72	118	61.0	8.1	479.0	4	2	91.0	3.4	1.7	7	41
19	Kurt Warner K. Warner	2	956	74	105	70.5	9.1	478.0	4	5	91.6	3.8	4.8	9	76
20	Donovan McNabb D. McNabb	2	914	67	98	68.4	9.3	457.0	7	1	117.5	7.1	1.0	6	32
21	Marc Bulger M. Bulger	2	903	65	87	74.7	10.4	451.5	7	2	124.8	8.0	2.3	3	18
22	Jake Plummer J. Plummer	2	964	62	111	55.9	8.7	482.0	7	4	90.8	6.3	3.6	3	17
23	Boomer Esiason B. Esiason	2	1,012	66	104	63.5	9.7	506.0	6	4	98.7	5.8	3.8	3	22
24	Joe Montana J. Montana	2	934	62	91	68.1	10.3	467.0	9	4	116.3	9.9	4.4	6	53
25	Vinny Testaverde V. Testaverde	2	950	61	111	55.0	8.6	475.0	4	5	76.8	3.6	4.5	4	33

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StatMuse has game-level data for passing yards going back to the 1950 season.

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Bills - w	11	5	0	.688
Dolphins - e	7	9	0	.438
Jets - e	3	13	0	.188
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Steelers	9	7	0	.563
Ravens	8	8	0	.500
Bengals - e	6	10	0	.375
Browns - e	4	12	0	.250
AFC South	W	L	T	PCT
Jaguars - x	12	4	0	.750
Texans - x	11	5	0	.688
Colts - e	8	8	0	.500
Titans - e	3	13	0	.188
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Eagles - y	11	5	0	.688
Cowboys - e	7	8	1	.469
Commanders - e	4	12	0	.250
Giants - e	3	13	0	.188
NFC North	W	L	T	PCT
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Packers - w	9	6	1	.594
Vikings - e	8	8	0	.500
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Panthers	8	8	0	.500
Buccaneers	7	9	0	.438
Falcons - e	6	9	0	.400
Saints - e	6	10	0	.375
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Rams - x	11	4	0	.733
Cardinals - e	3	13	0	.188