most nfl sacks by a afc player in 1 game ever regular season and playoffs in

Derrick Thomas has the most sacks in the AFC in a regular-season or postseason game, with 7 sacks against the Seahawks on November 11, 1990.

Interpreted as:
most NFL defensive sacks by a afc player in 1 game ever regular season and playoffs in
NAMESCKDATETMOPPTKLASTCOMBSCKYINTINT YDSINT TDFFFRFR TD
1Derrick Thomas
D. Thomas
7.0
11/11/1990
vs
0
0
0
0
2Khalil Mack
K. Mack
6.0
10/1/2023
vs
8
2
10
45
0
0
0
2
0
0
3Derrick Thomas
D. Thomas
6.0
9/6/1998
vs
0
0
0
0
4Myles Garrett
M. Garrett
5.0
10/26/2025
@
6
0
6
33
0
0
0
1
0
0
5Khalil Mack
K. Mack
5.0
12/13/2015
@
6
1
7
32
0
0
0
1
0
0
6Antwan Odom
A. Odom
5.0
9/20/2009
@
6
0
6
31
0
0
0
0
0
0
7Leslie O'Neal
L. O'Neal
5.0
11/16/1986
vs
0
0
0
0
8Howie Long
H. Long
5.0
10/2/1983
@
0
0
0
0
9Myles Garrett
M. Garrett
4.5
9/26/2021
vs
6
1
7
24.5
0
0
0
0
0
0
10Justin Houston
J. Houston
4.5
9/19/2013
@
6
1
7
28
0
0
0
1
2
0
11Mario Williams
M. Williams
4.5
9/15/2013
vs
5
1
6
24.5
0
0
0
0
0
0
12Cameron Wake
C. Wake
4.5
9/30/2012
@
4
1
5
30.5
0
0
0
0
0
0
13Willie McGinest
W. McGinest
4.5
1/7/2006
vs
6
2
8
35.5
0
0
0
0
0
0
14Chad Brown
C. Brown
4.5
10/13/1996
vs
1
4
0
0
15Johnie Cooks
J. Cooks
4.5
11/25/1984
@
0
0
0
0
16Myles Garrett
M. Garrett
4.0
11/16/2025
vs
5
0
5
17
0
0
0
0
0
0
17Will McDonald IV
W. McDonald IV
4.0
11/9/2025
vs
4
1
5
32
0
0
0
0
0
0
18Tuli Tuipulotu
T. Tuipulotu
4.0
9/28/2025
@
7
3
10
19
0
0
0
1
0
0
19Trey Hendrickson
T. Hendrickson
4.0
11/3/2024
vs
4
0
4
37
0
0
0
1
0
0
20T.J. Watt
T.J. Watt
4.0
1/3/2022
vs
5
0
5
25
0
0
0
0
0
0
21Maxx Crosby
M. Crosby
4.0
11/17/2019
vs
4
1
5
42
0
0
0
1
0
0
22Calais Campbell
C. Campbell
4.0
9/10/2017
@
4
2
6
17.5
0
0
0
0
0
0
23Cameron Wake
C. Wake
4.0
10/18/2015
@
4
0
4
25
0
0
0
2
0
0
24Justin Houston
J. Houston
4.0
12/28/2014
vs
6
0
6
21
0
0
0
1
0
0
25Antwan Barnes
A. Barnes
4.0
12/18/2011
vs
5
1
6
23
0
0
0
0
0
0
StatMuse has game-level data for sacks going back to the 1982 season.

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KC Chiefs

6 - 11

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Sun 4 Jan 2026

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