Since 2000, Matthew Stafford has the most passing yards in a game with exactly 0 passing touchdowns, with 443 yards versus the Falcons on December 22, 2012.

most passing yards with no passing touchdowns in the same game since 2000
Interpreted as:
most passing yards with no passing touchdowns by a player in the same regular-season game since 2000
12/22/2012Stafford10/29/2017Stafford11/11/2018Fitzpatrick11/18/2001Johnson9/29/2019Ryan11/15/2020Smith10/4/2015Smith9/26/2010Manning9/25/2005Brady10/31/2011Rivers9/18/2016Manning9/20/2020Bridgewater10/21/2018Winston11/6/2016Wentz11/4/2007Anderson12/14/2014Roethlisberger10/5/2003McNair12/21/2008Cutler9/15/2019Murray10/17/2004Hasselbeck9/19/2021Tannehill11/1/2009Manning12/10/2000Warner443423406399397390386386372369368367365364364360360359349349347347346
NAMEDATETMOPPYDSTDCMPATTPCTAVGTD%INTINT%SCKSCKYRATE
Matthew StaffordMatthew Stafford12/22/2012DETDETvsATLATL4430375666.17.90.011.80082.7
Matthew StaffordMatthew Stafford10/29/2017DETDETvsPITPIT4230274560.09.40.000.021291.3
Ryan FitzpatrickRyan Fitzpatrick11/11/2018TBTBvsWASWAS4060294170.79.90.024.92882.0
Brad JohnsonBrad Johnson11/18/2001TBTBvsCHICHI3990405671.47.10.023.62976.4
Matt RyanMatt Ryan9/29/2019ATLATLvsTENTEN3970355366.07.50.000.053388.3
Alex SmithAlex Smith11/15/2020WASWAS@DETDET3900385569.17.10.000.021589.2
Alex SmithAlex Smith10/4/2015KCKC@CINCIN3860314568.98.60.000.053895.2
Eli ManningEli Manning9/26/2010NYGNYGvsTENTEN3860344870.88.00.024.222277.3
Tom BradyTom Brady9/25/2005NENE@PITPIT3720314175.69.10.012.432692.7
Philip RiversPhilip Rivers10/31/2011SDSD@KCKC3690264163.49.00.024.932472.1
Eli ManningEli Manning9/18/2016NYGNYGvsNONO3680324178.09.00.000.0215104.1
Teddy BridgewaterTeddy Bridgewater9/20/2020CARCAR@TBTB3670334278.68.70.024.852783.2
Jameis WinstonJameis Winston10/21/2018TBTBvsCLECLE3650325261.57.00.023.842366.6
Carson WentzCarson Wentz11/6/2016PHIPHI@NYGNYG3640274757.47.70.024.321764.5
Derek AndersonDerek Anderson11/4/2007CLECLEvsSEASEA3640294860.47.60.012.10075.3
Ben RoethlisbergerBen Roethlisberger12/14/2014PITPIT@ATLATL3600273577.110.30.000.017109.2
Steve McNairSteve McNair10/5/2003TENTEN@NENE3600234551.18.00.012.221968.8
Jay CutlerJay Cutler12/21/2008DENDENvsBUFBUF3590254555.68.00.012.21872.4
Kyler MurrayKyler Murray9/15/2019ARIARI@BALBAL3490254062.58.70.000.032090.5
Matt HasselbeckMatt Hasselbeck10/17/2004SEASEA@NENE3490275054.07.00.024.03859.5
Ryan TannehillRyan Tannehill9/19/2021TENTEN@SEASEA3470274067.58.70.000.032794.5
Peyton ManningPeyton Manning11/1/2009INDINDvsSFSF3470314864.67.20.000.032086.0
Kurt WarnerKurt Warner12/10/2000STLSTLvsMINMIN3460273284.410.80.000.000111.7
Carson PalmerCarson Palmer10/23/2016ARIARIvsSEASEA3420294959.27.00.000.043180.5
Matt RyanMatt Ryan11/4/2012ATLATLvsDALDAL3420243470.610.10.000.0312102.8