The Buffalo Bills allowed their most points in a game in 2021 against the Colts on November 21, 2021, with 41 points.
Interpreted as:
most points allowed in a regular-season game by bills defense in 2021| TEAM | OPP PTS | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 41 | 11/21/2021 | vs | L 15-41 | 2 | 19 | 311 | 370 | 50.0 | |||
| 2 | | Bills | 34 | 10/18/2021 | @ | L 31-34 | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 3 | | Bills | 33 | 12/12/2021 | @ | L 27-33 | 3 | 27 | 466 | 488 | 15.4 | 66.7 | ||
| 4 | | Bills | 23 | 9/12/2021 | vs | L 16-23 | 1 | 22 | 371 | 252 | 44.4 | 33.3 | ||
| 5 | | Bills | 21 | 12/26/2021 | @ | W 33-21 | 4 | 28 | 428 | 288 | 50.0 | 75.0 | ||
| 6 | | Bills | 21 | 9/26/2021 | vs | W 43-21 | 5 | 29 | 481 | 290 | 60.0 | 0.0 | ||
| 7 | | Bills | 20 | 10/10/2021 | @ | W 38-20 | 5 | 20 | 436 | 392 | 45.5 | |||
| 8 | | Bills | 17 | 11/14/2021 | @ | W 45-17 | 6 | 26 | 489 | 366 | 57.1 | |||
| 9 | | Bills | 15 | 1/2/2022 | vs | W 29-15 | 4 | 28 | 351 | 265 | 58.3 | 100.0 | ||
| 10 | | Bills | 14 | 12/19/2021 | vs | W 31-14 | 4 | 21 | 312 | 275 | 42.9 | 100.0 | ||
| 11 | | Bills | 14 | 12/6/2021 | vs | L 10-14 | 1 | 16 | 230 | 241 | 30.8 | 0.0 | ||
| 12 | | Bills | 11 | 10/31/2021 | vs | W 26-11 | 3 | 24 | 351 | 262 | 46.2 | 0.0 | ||
| 13 | | Bills | 10 | 1/9/2022 | vs | W 27-10 | 3 | 25 | 424 | 63 | 44.4 | 0.0 | ||
| 14 | | Bills | 9 | 11/7/2021 | @ | L 6-9 | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 15 | | Bills | 6 | 11/25/2021 | @ | W 31-6 | 4 | 21 | 361 | 190 | 61.5 | 100.0 |
WAS
NYJMore Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
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NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
